85175-85-5

Basic information

• Product Name: 8-METHOXY-1,3-DIHYDRO-2H-3-BENZAZEPIN-2-ONE
• Synonyms: 8-METHOXY-1,3-DIHYDRO-2H-3-BENZAZEPIN-2-ONE;2H-3-BENZAZEPIN-2-ONE, 1,3-DIHYDRO-8-METHOXY-;8-Methoxy-1H-benzo[d]azepin-2(3H)-one;8-Methoxy-1,3-dihydro-benzo[d]azepin-2-one;8-METHOXY-1H-BENZO[D]AZEPIN-2(3H)-ONE(WXC05716);(Z)-8-methoxy-1H-benzo[d]azepin-2(3H)-one
• CAS NO: 85175-85-5
• Molecular Formula: C₁₁H₁₁NO₂
• Molecular Weight: 189.21
• Mol File: 85175-85-5.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 8-METHOXY-1,3-DIHYDRO-2H-3-BENZAZEPIN-2-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 8-METHOXY-1,3-DIHYDRO-2H-3-BENZAZEPIN-2-ONE(85175-85-5)
• EPA Substance Registry System: 8-METHOXY-1,3-DIHYDRO-2H-3-BENZAZEPIN-2-ONE(85175-85-5)

Safety Data

• Hazardous Substances Data: 85175-85-5(Hazardous Substances Data)

Usage

General Description

8-Methoxy-1,3-dihydro-2H-3-benzazepin-2-one is a chemical compound belonging to the class of benzazepines. It is a derivative of 3-benzazepine, and the addition of a methoxy group at the 8th position of the molecule gives it its unique properties. 8-METHOXY-1,3-DIHYDRO-2H-3-BENZAZEPIN-2-ONE is known for its potential pharmaceutical applications, particularly in the development of drugs for various neurological and psychiatric disorders. It can also be used as a starting material for the synthesis of other compounds with potential pharmacological activity. The precise mechanism of action and specific uses of 8-methoxy-1,3-dihydro-2H-3-benzazepin-2-one are still being studied, but it holds promise for potential therapeutic applications in the future.

Upstream product

• 6834-42-0 3-methoxyphenylacetic acid chloride 
• 1798-09-0 m-methoxyphenylacetic acid 
• 108962-85-2 N-(2,2-dimethoxyethyl)-2-(3-methoxyphenyl)acetamide 

Downstream Products

• 36133-00-3 2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol 
• 1022949-63-8 5-chloro-N₄-((2-((isopropylsulfonyl)phenylamino)pyrimidin-2-yl)amino-N₂-8-methoxy-4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)ethanol 
• 50351-80-9 7-methoxy-2,3,4,5-tetrahydro-1H-benz[d]azepine 
• 720690-73-3 6-[(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-N-methyl-3-pyridinecarboxamide 
• 37682-06-7 8-methoxy-2,3,4,5-tetrahydro-2-oxo-1H-3-benzazepine 
• 96254-82-9 3-(3-{[2-(3,4-Dimethoxy-phenyl)-ethyl]-methyl-amino}-propyl)-8-methoxy-1,3,4,5-tetrahydro-benzo[d]azepin-2-one 

Relevant articles and documents

Design of oxa-spirocyclic PHOX ligands for the asymmetric synthesis of lorcaserin: Via iridium-catalyzed asymmetric hydrogenation

Phosphine-oxazoline (PHOX) ligands are a very important class of privileged ligands in asymmetric catalysis. A series of highly rigid oxa-spiro phosphine-oxazoline (O-SIPHOX) ligands based on O-SPINOL was synthesized efficiently, and their iridium complexes were synthesized by coordination of the O-SIPHOX ligands to [Ir(cod)Cl]2 in the presence of sodium tetrakis-3,5-bis(trifluoromethyl)phenylborate (NaBArF). The cationic iridium complexes showed high reactivity and excellent enantioselectivity in the asymmetric hydrogenation of 1-methylene-tetrahydro-benzo[d]azepin-2-ones (up to 99% yield and up to 99% ee). A key intermediate of the anti-obesity drug lorcaserin could be efficiently synthesized using this protocol.

A new facile synthetic route to [11C]GSK189254, a selective PET radioligand for imaging of CNS histamine H3 receptor

GSK189254 and its corresponding precursor GSK185071B were synthesized from 3-methoxyphenylacetic acid with 6-chloropyridine-3-carbolic acid or 6-chloronicotinamide in 8 and 7 steps with either 6% or 7% and either 14% or 16% yield, respectively. [11/

SELECTIVE ESTROGEN RECEPTOR MODULATORS

The present invention provides a compound represented by the following formula (I); [wherein T represents a single bond, a C1-C4 alkylene group which may have a substituent and the like; formula (I-1) represents a single bond or a double bond; A represents a single bond, a bivalent 5- to 14-membered heterocyclic group which may have a substituent and the like; Y represents a single bond and the like; Z represents a methylene group and the like; ring G represents a phenylene group and the like which may condense with a 5- to 6-membered ring and may have a heteroatom; Ra and Rb are the same as or different from each other and represent a hydrogen atom and the like; W represents a single bond and the like; R' represents 1 to 4 independent hydrogen atoms and the like; and R" represents 1 to 4 independent hydrogen atoms and the like] or a salt thereof, or a hydrate thereof.