111-68-2Relevant articles and documents
HYDROAMMONOLYSIS OF DI-1-HEPTYL ETHER AND THE 1-HEPTYL ESTER OF ENANTHIC ACID
Kliger, G. A.,Lesik, O. A.,Marchevskaya, E. V.,Glebov, L. S.,Loktev, S. M.
, p. 2383 - 2384 (1986)
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Oxidation of aldehydes to acyl azides by chromic anhydride-azidotrimethylsilane
Lee,Kwak
, p. 3165 - 3166 (1992)
Aldehydes are efficiently oxidized to acyl azides by azidotrimethylsilane and chromic anhydride at room temperature (aromatic), or at -10°C (aliphatic).
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Saito,I.,Sugiyama,H.,Ito,S.
, p. 1598 (1981)
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Selective Room-Temperature Hydrogenation of Amides to Amines and Alcohols Catalyzed by a Ruthenium Pincer Complex and Mechanistic Insight
Ben-David, Yehoshoa,Kar, Sayan,Kumar, Amit,Leitus, Gregory,Milstein, David,Rauch, Michael
, p. 5511 - 5515 (2020/07/21)
We report a room-temperature protocol for the hydrogenation of various amides to produce amines and alcohols. Compared with most previous reports for this transformation, which use high temperatures (typically, 100-200 °C) and H2 pressures (10-100 bar), this system proceeds under extremely mild conditions (RT, 5-10 bar of H2). The hydrogenation is catalyzed by well-defined ruthenium-PNNH pincer complexes (0.5 mol %) with potential dual modes of metal-ligand cooperation. An unusual Ru-amidate complex was formed and crystallographically characterized. Mechanistic investigations indicate that the room-temperature hydrogenation proceeds predominantly via the Ru-N amido/amine metal-ligand cooperation.
Facile synthesis of supported Ru-Triphos catalysts for continuous flow application in selective nitrile reduction
Konrath, Robert,Heutz, Frank J.L.,Steinfeldt, Norbert,Rockstroh, Nils,Kamer, Paul C.J.
, p. 8195 - 8201 (2019/09/19)
The selective catalytic hydrogenation of nitriles represents an important but challenging transformation for many homogeneous and heterogeneous catalysts. Herein, we report the efficient and modular solid-phase synthesis of immobilized Triphos-type ligands in very high yields, involving only minimal work-up procedures. The corresponding supported ruthenium-Triphos catalysts are tested in the hydrogenation of various nitriles. Under mild conditions and without the requirement of additives, the tunable supported catalyst library provides selective access to both primary amines and secondary imines. Moreover, the first application of a Triphos-type catalyst in a continuous flow process is presented demonstrating high catalyst life-time over at least 195 hours without significant activity loss.