163837-56-7

Basic information

• Product Name: 1-[(4-CHLOROPHENYL)(PHENYL)METHYL]-4-[(4-METHYLPHENYL)SULFONYL]PIPERAZINE
• Synonyms: 1-[(4-CHLOROPHENYL)(PHENYL)METHYL]-4-[(4-METHYLPHENYL)SULFONYL]PIPERAZINE;(-)-1-[1-(4-CHLOROPHENYL)PHENYLMETHYL]-4-[(4-METHYLPHENYL)SULFONYL]PIPERAZINE;(R)-1-((4-Chlorophenyl)(phenyl)Methyl)-4-tosylpiperazine;1-((4-chlorophenyl)(phenyl)Methyl)-4-tosylpiperazine
• CAS NO: 163837-56-7
• Molecular Formula: C24H25ClN2O2S
• Molecular Weight: 440.99
• Mol File: 163837-56-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 560.849 °C at 760 mmHg
• Flash Point: 292.991 °C
• Appearance: Gray power
• Density: 1.274g/cm³
• CAS DataBase Reference: 1-[(4-CHLOROPHENYL)(PHENYL)METHYL]-4-[(4-METHYLPHENYL)SULFONYL]PIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[(4-CHLOROPHENYL)(PHENYL)METHYL]-4-[(4-METHYLPHENYL)SULFONYL]PIPERAZINE(163837-56-7)
• EPA Substance Registry System: 1-[(4-CHLOROPHENYL)(PHENYL)METHYL]-4-[(4-METHYLPHENYL)SULFONYL]PIPERAZINE(163837-56-7)

Safety Data

• Hazardous Substances Data: 163837-56-7(Hazardous Substances Data)

Usage

General Description

1-[(4-chlorophenyl)(phenyl)methyl]-4-[(4-methylphenyl)sulfonyl]piperazine is a compound belonging to the piperazine class of chemicals. It consists of a piperazine core with a 4-chlorophenyl and a phenyl group attached to the nitrogen atoms, as well as a 4-methylphenylsulfonyl group attached to one of the carbon atoms. 1-[(4-CHLOROPHENYL)(PHENYL)METHYL]-4-[(4-METHYLPHENYL)SULFONYL]PIPERAZINE has potential pharmaceutical applications, particularly in the field of medicinal chemistry. It may possess biological activities and is of interest for further research and development in the pharmaceutical industry.

Upstream product

• 42137-88-2 N,N-bis(2-chloroethyl)-p-toluenesulfonamide 
• 163837-32-9 (S)-4-chloro-α-phenyl-benzenemethanamine 
• 28022-43-7 p-chlorobenzhydrylamine 
• 163837-57-8 (R)-(4-chlorophenyl)(phenyl)methylamine 
• 98-59-9 p-toluenesulfonyl chloride 
• 108-86-1 bromobenzene 
• 27106-51-0 1-tosylpiperazine 
• 104-88-1 4-chlorobenzaldehyde 
• 439695-63-3 (R_S,S)-(1-(4-chlorophenyl)-1-phenylmethyl)-2-methylpropanesulfinamide 
• 336105-23-8 (R)-(-)-N-[(1E)-(4-chlorophenyl)methylene]-2-methyl-2-propanesulfinamide 
• 186249-76-3 (R,E)-2-methyl-N-(phenylmethylene)-2-propanesulfinamide 
• 100-52-7 benzaldehyde 

Downstream Products

• 246870-46-2 (S)-(-)-cetirizine ethyl ester 
• 439858-21-6 1-[(S)-(4-chlorophenyl)(phenyl)methyl]piperazine 

Relevant articles and documents

Preparation method of levocetirizine

The invention provides a preparation method of levocetirizine. The preparation method comprises following steps: carrying out a reaction on a compound represented by a formula (I) under the action ofa reduction system and L-tartaric acid to obtain a compound represented by a formula (II); and reacting the compound shown in a formula (II) with a compound shown in a formula (III) under the action of NaH, N,N-dimethyl formamide and tetrabutyl ammonium bromide to obtain levocetirizine. The levocetirizine is prepared by taking the compound shown by the formula (I) and the compound shown by the formula (III) as raw materials, at first, the compound shown by the formula (I) is de-protected and then racemized to obtain the compound shown by the formula (II); and the compound shown by the formula(II) and the compound shown by the formula (III) carry out reactions to obtain levocetirizine. The provided method is short in reaction route, the yield can reach 54% or above, and the purity can reach 99.65% at most.

Asymmetric synthesis of cetirizine dihydrochloride

Practical route technology for the preparation of (S)-cetirizine·2HCl via diastereoselective organometallic addition to N-tert-butanesulfinyl aldimines is disclosed.

Enantiomers of 1-[(4-chlorophenyl)phenylmethyl]-4-[(4-methylphenyl) sulfonyl]piperazine

Levorotatory and dextrorotatory enantiomers of 1-[(4-chlorophenyl)phenylmethyl]-4-[(4-methylphenyl)sulfonyl]piperazine of the formula STR1 their preparation and use for the preparation of substantially optically pure enantiomers of 1-[(4-chlorophenyl)phenylmethyl]piperazine, which are themselves valuable intermediate products for the preparation of optically active therapeutic compounds having a very high degree of optical purity.