168297-97-0

Basic information

• Product Name: 2-Oxazolidinone, 5,5-dimethyl-3-(1-oxo-3-phenylpropyl)-4-(phenylmethyl)-, (4S)-
• CAS NO: 168297-97-0
• Molecular Formula: C21H23NO3
• Molecular Weight: 337.419
• Mol File: 168297-97-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-Oxazolidinone, 5,5-dimethyl-3-(1-oxo-3-phenylpropyl)-4-(phenylmethyl)-, (4S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Oxazolidinone, 5,5-dimethyl-3-(1-oxo-3-phenylpropyl)-4-(phenylmethyl)-, (4S)-(168297-97-0)
• EPA Substance Registry System: 2-Oxazolidinone, 5,5-dimethyl-3-(1-oxo-3-phenylpropyl)-4-(phenylmethyl)-, (4S)-(168297-97-0)

Safety Data

• Hazardous Substances Data: 168297-97-0(Hazardous Substances Data)

Upstream product

• 501-52-0 3-Phenylpropionic acid 
• 51987-73-6 (S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid methyl ester 
• 2577-90-4 methyl (2S)-2-amino-3-phenylpropanoate 
• 63-91-2 L-phenylalanine 
• 1373038-24-4 C₂₁H₂₄F₇NO₃ 
• 1373037-98-9 C₂₁H₂₆F₃NO₃ 
• 1373037-72-9 (S)-4-benzyl-3-(2-cyclohexylacetyl)-5,5-dimethyloxazolidin-2-one 
• 1207362-36-4 (S)-4-benzyl-3-hexanoyl-5,5-dimethyloxazolidin-2-one 
• 320606-07-3 (S)-3-(2'-benzyl-3'-phenylpropionyl)-4-benzyl-5,5-dimethyloxazolidin-2-one 
• 168297-85-6 (S)-4-benzyl-5,5-dimethyloxazolidin-2-one 
• 645-45-4 hydrocinnamic acid chloride 

Downstream Products

• 1647060-99-8 (S)-4-benzyl-5,5-dimethyl-N-[(S)-2-hydroxypropanoyl]-1,3-oxazolidin-2-one 
• 1527484-95-2 (S)-4-benzyl-N-(5-hexynoyl)-5,5-dimethyl-1,3-oxazolidin-2-one 
• 17131-14-5 (S)-(-)-3-phenyl-1,2-propanediol 
• 168297-85-6 (S)-4-benzyl-5,5-dimethyloxazolidin-2-one 
• 13673-95-5 (S)-methyl 2-hydroxy-3-phenylpropanoate 
• 1527484-94-1 (S)-4-benzyl-N-(5-hexenoyl)-5,5-dimethyl-1,3-oxazolidin-2-one 
• 1312341-52-8 (S)-4-benzyl-5,5-dimethyl-N-(3-methylbutanoyl)-1,3-oxazolidin-2-one 
• 320606-12-0 (S)-4-benzyl-N-butanoyl-5,5-dimethyl-1,3-oxazolidin-2-one 
• 168297-93-6 (S)-4-benzyl-5,5-dimethyl-3-propanoyl-1,3-oxazolidin-2-one 
• 936331-31-6 (S)-3-phenyl-2-(2,2,6,6-tetramethylpiperidin-1-yloxyl)propan-1-ol 
• 1647060-96-5 (S)-4-benzyl-5,5-dimethyl-N-[(R)-2-(1-(2,2,6,6-tetramethylpiperidinyl)oxy)-3,3,3-trifluoropro-panoyl]-1,3-oxazolidin-2-one 
• 1647060-95-4 (S)-4-benzyl-N-[(S)-2-cyclopropyl-2-(1-(2,2,6,6-tetramethylpiperidinyl)oxy)acetyl]-5,5-dimethyl-1,3-oxazolidin-2-one 
• 1647060-94-3 (S)-4-benzyl-N-[(S)-5-methoxy-5-oxo-2-(1-(2,2,6,6-tetramethylpiperidinyl)oxy)pentanoyl]-5,5-dimethyl-1,3-oxazolidin-2-one 

Relevant articles and documents

Stereoselective Alkylation of Chiral Titanium(IV) Enolates with tert-Butyl Peresters

Here, we present a new stereoselective alkylation of titanium(IV) enolates of chiral N-acyl oxazolidinones with tert-butyl peresters from Cα-branched aliphatic carboxylic acids, which proceeds through the decarboxylation of the peresters and the subsequent formation of alkyl radicals to produce the alkylated adducts with an excellent diastereoselectivity. Theoretical calculations account for the observed reactivity and the outstanding stereocontrol. Importantly, the resultant compounds can be easily converted into ligands for asymmetric and catalytic transformations.

A simple method for asymmetric trifluoromethylation of N-acyl oxazolidinones via Ru-catalyzed radical addition to zirconium enolates

A Ru-catalyzed direct thermal trifluoromethylation and perfluoroalkylation of N-acyloxazolidinones has been developed. The reaction is experimentally simple and requires inexpensive reagents while providing good yields of products with good levels of stereocontrol. Preliminary studies have shown notable compatibility with functional groups, aromatics, and certain heteroaromatic substituents. The described method provides a useful alternative for the synthesis of fluorinated materials in an experimentally convenient manner.