25931-47-9

Basic information

• Product Name: POLY-EPSILON-CBZ-L-LYSINE
• Synonyms: POLY-E-CARBOBENZOXY-L-LYSINE;POLY-EPSILON-CBZ-L-LYSINE;POLY-EPSILON-CBZ-L-LYSINE*MOL WT 1000-40 00;POLY-E-CBZ-L-LYSINE;poly(epsilon-benzyloxycarbonyl-L-lysine);epsilon-carbobenzyloxy-L-lysine homopolymer;N6-Carbobenzoxy-L-lysine homopolymer;N'-Benzyloxycarbonyl-L-lysine homopolymer
• CAS NO: 25931-47-9
• Molecular Formula: C14H20N2O4
• Molecular Weight: 280.3196
• EINECS: 216-737-8
• Product Categories: Amino Acids;Homopolymers;Polyamino Acids
• Mol File: 25931-47-9.mol
• Article Data: 30

Chemical Properties

• Boiling Point: 499.6°Cat760mmHg
• Flash Point: 255.9°C
• Appearance: /
• Density: 1.206g/cm³
• Storage Temp.: −20°C
• CAS DataBase Reference: POLY-EPSILON-CBZ-L-LYSINE(CAS DataBase Reference)
• NIST Chemistry Reference: POLY-EPSILON-CBZ-L-LYSINE(25931-47-9)
• EPA Substance Registry System: POLY-EPSILON-CBZ-L-LYSINE(25931-47-9)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 25931-47-9(Hazardous Substances Data)

Usage

General Description

POLY-EPSILON-CBZ-L-LYSINE is a polymer made from the amino acid L-lysine that has been protected by attaching a carbobenzoxy (CBZ) group to its epsilon amino group. This chemical modification allows for better control of the polymerization process and the resulting properties of the polymer. POLY-EPSILON-CBZ-L-LYSINE has applications in the field of drug delivery and biomaterials, as it can be designed to degrade at specific rates and release drugs at particular sites within the body. Its controlled release capabilities and biocompatibility make it a valuable tool in the development of new pharmaceutical and medical devices.

Upstream product

• 70-54-2 2,6-diaminocaproic acid 
• 56-87-1 L-lysine 
• 28170-07-2 benzyl phenyl carbonate 
• 42533-12-0 Z(OMe)-Lys(Z)-OH 
• 63842-04-6 sodium benzyloxycarbonyl thiosulfate 
• 7675-62-9 N^α-2-nitrobenzenesulfenyl-N^ε-benzyloxycarbonyllysine dicyclohexylammonium salt 
• 42893-94-7 Cu(Nε-benzyloxy carbonyl-lysinate)2 
• 47115-81-1 Cu(lysinate)2 
• 501-53-1 benzyl chloroformate 
• 3742-91-4 N-(benzyloxycarbonyl)piperidine 
• 657-27-2 L-Lysine hydrochloride 
• 923-27-3 D-lysine 
• 7274-88-6 D-lysine hydrochloride 
• 67427-40-1 For-D-Lys(-Z)-OH 

Downstream Products

• 107328-26-7 N⁶-benzyloxycarbonyl-N²-propionyl-lysine 
• 107923-91-1 N⁶-benzyloxycarbonyl-N²-butyryl-lysine 
• 109560-65-8 N⁶-benzyloxycarbonyl-N²-valeryl-lysine 
• 110663-53-1 N-[N⁶-carbamimidoyl-N²-(toluene-4-sulfonyl)-L-lysyl]-glycine 
• 103644-54-8 N-[N⁶-benzyloxycarbonyl-N²-(toluene-4-sulfonyl)-L-lysyl]-glycine amide 
• 118982-49-3 N-[N⁶-benzyloxycarbonyl-N²-(toluene-4-sulfonyl)-L-lysyl]-glycine 
• 121255-30-9 4-{[N⁶-benzyloxycarbonyl-N²-(toluene-4-sulfonyl)-L-lysyl]-amino}-benzoic acid benzyl ester 
• 17039-40-6 α-N-benzoyl-L-lysone methyl ester 
• 50732-04-2 N^α-benzoyl-N^ε-benzyloxycarbonyl-L-lysine methyl ester 

Relevant articles and documents

Nitrile Synthesis by Aerobic Oxidation of Primary Amines and in situ Generated Imines from Aldehydes and Ammonium Salt with Grubbs Catalyst

Herein, a Grubbs-catalyzed route for the synthesis of nitriles via the aerobic oxidation of primary amines is reported. This reaction accommodates a variety of substrates, including simple primary amines, sterically hindered β,β-disubstituted amines, allylamine, benzylamines, and α-amino esters. Reaction compatibility with various functionalities is also noted, particularly with alkenes, alkynes, halogens, esters, silyl ethers, and free hydroxyl groups. The nitriles were also synthesized via the oxidation of imines generated from aldehydes and NH4OAc in situ. (Figure presented.).

Novel aminopeptidase N inhibitors with improved antitumor activities

A series of aminopeptidase N (APN) inhibitors were designed and synthesized. Enzyme inhibitory, docking and antiproliferative studies were performed to evaluate the derived molecules. Molecule D15, with IC50 values of 10.9 μM, showed the best performance in the APN enzymatic inhibition assay. The binding pattern of molecule D9 and D15 in the active site of APN was predicted by docking studies. Hydrophobic and H-bond interactions were discovered to make key roles in the ligand-receptor bindings. Compared with the previous C7, several molecules such as D9, D14 and D15, exhibited significantly improved activities in inhibiting the growth of HL-60, ES-2, A549 and PLC cell lines.

Concise total synthesis of aplysinellamides A and B

Concise and efficient total syntheses of bromotyrosine-derived metabolites aplysinellamides A and B, isolated from Australian marine sponge Aplysinella sp., have been accomplished in seven steps. A condensation between cinnamic acid and Boc-D-lysine methyl ester was applied to form the amide skeleton as a key step.