7274-88-6

Basic information

• Product Name: D-Lysine hydrochloride
• Synonyms: D-LYSINE HCL;D-LYSINE HYDROCHLORIDE;D-LYSINE HYDROCHLORIDE SALT;D-(-)-LYSINE MONOHYDROCHLORIDE;D-LYSINE MONOHYDROCHLORIDE;D-LYS HYDROCHLORIDE;D-2,6-DIAMINOCAPROIC ACID, HYDROCHLORIDE;D-2,6-DIAMINOHEXANOIC ACID, HYDROCHLORIDE
• CAS NO: 7274-88-6
• Molecular Formula: C₆H₁₄N₂O₂*ClH
• Molecular Weight: 182.65
• EINECS: 230-691-6
• Product Categories: Lysine [Lys, K];Amino Acids and Derivatives;alpha-Amino Acids;Amino Acids;Biochemistry;Amino hydrochloride;Amino acid;Thiophenes
• Mol File: 7274-88-6.mol
• Article Data: 2

Chemical Properties

• Melting Point: 266 °C (dec.)(lit.)
• Boiling Point: 311.5 °C at 760 mmHg
• Flash Point: 142.2 °C
• Appearance: White/Crystalline Powder
• Vapor Pressure: 0.000123mmHg at 25°C
• Storage Temp.: Store at RT.
• Solubility: H2O: soluble
• Water Solubility: SOLUBLE
• BRN: 4356907
• CAS DataBase Reference: D-Lysine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: D-Lysine hydrochloride(7274-88-6)
• EPA Substance Registry System: D-Lysine hydrochloride(7274-88-6)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 3
• RTECS: OL5632500
• F: 21
• TSCA: Yes
• Hazardous Substances Data: 7274-88-6(Hazardous Substances Data)

Usage

Description

D-lysine hydrochloride is the hydrochloride salt form of D-lysine. D-lysine is a kind of D-form amino acid (not the natural amino acid in organisms, which is in L-form). It is often supplied to animal feed. D-Lysine is used as a component of polymers (poly-D-lysine), surfactants and biofilms to confer a positive (cationic) charge. The poly-D-lysine can be used to facilitate the attachment of proteins and cells to solid surface through enhancing the electrostatic interaction between negatively-charged ion of the cell membrane and the positively-charged ions of the culture surface. In histochemical field, it is used to coat slides to promote cell attachment.

Chemical Properties

white crystalline powder

Uses

D-Lysine is used as a component of a wide array of polymers (poly-D-lysine), surfactants and biofilms to confer a positive (cationic) charge.

Definition

ChEBI: The hydrochloride salt of D-lysine.

References

https://pubchem.ncbi.nlm.nih.gov/compound/D-Lysine#section=Top http://www.alamanda-polymers.com/content/poly-l-lysine-and-poly-d-lysine http://www.sigmaaldrich.com/catalog/product/sigma/l8021?lang=zh®ion=CN

InChI:InChI=1/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m1/s1

Synthetic route

D-lysine hydrochloride (7274-88-6) + 2,2-dimethoxy-propane (77-76-9) → D-lysine methyl ester bis-hydrochloride

Conditions	Yield
With hydrogenchloride In methanol at 20℃; for 15h; Reflux;	95%

4-phenylazobenzoyl chloride (104-24-5) + D-lysine hydrochloride (7274-88-6) → bis-D-lysine

Conditions	Yield
With sodium hydroxide In 1,4-dioxane	64%

2,5-dioxopyrrolidin-1-yl 6-(((tert-butyldimethylsilyl)oxy)methyl)nicotinate (1277191-84-0) + N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) + D-lysine hydrochloride (7274-88-6) → (R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-6-(6-(((tert-butyldimethylsilyl)oxy)methyl)nicotinamido)hexanoic acid (1277191-85-1)

Conditions	Yield
Stage #1: D-lysine hydrochloride With copper(ll) sulfate pentahydrate; sodium hydrogencarbonate In water for 2h; Reflux; Stage #2: 2,5-dioxopyrrolidin-1-yl 6-(((tert-butyldimethylsilyl)oxy)methyl)nicotinate In N,N-dimethyl-formamide at 0 - 20℃; for 16h; Stage #3: N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide Further stages;	62%

palmitic acid N-succinimide ester (14464-31-4) + D-lysine hydrochloride (7274-88-6) → Pam-DLys(Pam)-OH (870789-29-0)

Conditions	Yield
Stage #1: palmitic acid N-succinimide ester; D-lysine hydrochloride With sodium carbonate In 1,4-dioxane at 20℃; for 48h; Stage #2: With hydrogenchloride In 1,4-dioxane; water	61%

D-lysine hydrochloride (7274-88-6) + acryloyl chloride (814-68-6) → (R)-6-acrylamido-2-aminohexanoic acid

Conditions	Yield
With copper(ll) sulfate pentahydrate; sodium carbonate; sodium hydroxide In water at 0 - 20℃; for 4h; Inert atmosphere;	45.3%

D-lysine hydrochloride (7274-88-6) → (R)-3-amino-azepan-2-one (28957-33-7)

Conditions	Yield
With hexamethyldisilazan In toluene for 168h; Heating / reflux;	15%
Stage #1: D-lysine hydrochloride With thionyl chloride In methanol at -60 - 20℃; for 12h; Stage #2: With sodium methylate In methanol for 4h; Reflux;
Multi-step reaction with 2 steps 1: hydrogenchloride / 3 h / Reflux 2: sodium methylate / methanol / 4 h / Reflux View Scheme

tert-butyl fluoroformate (18595-34-1) + D-lysine hydrochloride (7274-88-6) → Nε-(tert-butoxycarbonyl)-D-lysine (31202-69-4)

Conditions	Yield
(i) CuCO3*Cu(OH)2, (ii) aq. NaOH, NaHCO3, dioxane; Multistep reaction;

2,2-dimethylpropanoic anhydride (1538-75-6) + 2-methyl-1-nitroisourea (57538-27-9) + D-lysine hydrochloride (7274-88-6) → Nα-tert-butoxycarbonyl-NG-nitro-D-homoarginine (132718-70-8)

Conditions	Yield
Yield given. Multistep reaction;

D-lysine hydrochloride (7274-88-6) + benzyl chloroformate (501-53-1) → (R)-2-amino-6-(((benzyloxy)carbonyl)amino)hexanoic acid (34404-32-5, 1155-64-2, 32302-83-3)

Conditions	Yield
With copper (II) carbonate hydroxide; sodium hydroxide 1.) H2O, reflux, 2.5 h, 2.) RT, overnight; Yield given. Multistep reaction;

acetic anhydride (108-24-7) + D-lysine hydrochloride (7274-88-6) → Nε-acetyl-lysine (51621-57-9)

Conditions	Yield
With TEA 1.) H2O, reflux, 30 min, 2.) H2O, MeOH, a) 0 deg C, 1.5 h, b) RT, 1 h; Yield given. Multistep reaction;

D-lysine hydrochloride (7274-88-6) + benzaldehyde (100-52-7) → Nε-benzylidene-D-lysine

Conditions	Yield
With lithium hydroxide at 0℃;

D-lysine hydrochloride (7274-88-6) → Nα-carbobenzoxy-D-lysine (70671-54-4)

Conditions	Yield
Multi-step reaction with 2 steps 1.1: aq. LiOH / 0 °C 2.1: aq. NaOH / ethanol / 0.33 h / -10 - 20 °C 2.2: HCl / ethanol / 0.17 h / 50 °C View Scheme

D-lysine hydrochloride (7274-88-6) → (R)-3-Benzyloxycarbonylamino-7-hydroxy-heptanoic acid methyl ester

Conditions	Yield
Multi-step reaction with 6 steps 1.1: aq. LiOH / 0 °C 2.1: aq. NaOH / ethanol / 0.33 h / -10 - 20 °C 2.2: HCl / ethanol / 0.17 h / 50 °C 3.1: NaNO2; AcOH / 6 h / 40 °C 4.1: Et3N; isobutyl chloroformate / tetrahydrofuran / 1 h / -25 - -10 °C 4.2: tetrahydrofuran; diethyl ether / -10 - 20 °C 5.1: PhCO2Ag; Et3N / -25 - 20 °C 6.1: K2CO3 / methanol / 6 h / 0 °C View Scheme

D-lysine hydrochloride (7274-88-6) → Acetic acid (R)-5-benzyloxycarbonylamino-7-diazo-6-oxo-heptyl ester

Conditions	Yield
Multi-step reaction with 4 steps 1.1: aq. LiOH / 0 °C 2.1: aq. NaOH / ethanol / 0.33 h / -10 - 20 °C 2.2: HCl / ethanol / 0.17 h / 50 °C 3.1: NaNO2; AcOH / 6 h / 40 °C 4.1: Et3N; isobutyl chloroformate / tetrahydrofuran / 1 h / -25 - -10 °C 4.2: tetrahydrofuran; diethyl ether / -10 - 20 °C View Scheme

D-lysine hydrochloride (7274-88-6) → (R)-6-Acetoxy-2-benzyloxycarbonylamino-hexanoic acid

Conditions	Yield
Multi-step reaction with 3 steps 1.1: aq. LiOH / 0 °C 2.1: aq. NaOH / ethanol / 0.33 h / -10 - 20 °C 2.2: HCl / ethanol / 0.17 h / 50 °C 3.1: NaNO2; AcOH / 6 h / 40 °C View Scheme

D-lysine hydrochloride (7274-88-6) → (R)-7-Acetoxy-3-benzyloxycarbonylamino-heptanoic acid methyl ester

Conditions	Yield
Multi-step reaction with 5 steps 1.1: aq. LiOH / 0 °C 2.1: aq. NaOH / ethanol / 0.33 h / -10 - 20 °C 2.2: HCl / ethanol / 0.17 h / 50 °C 3.1: NaNO2; AcOH / 6 h / 40 °C 4.1: Et3N; isobutyl chloroformate / tetrahydrofuran / 1 h / -25 - -10 °C 4.2: tetrahydrofuran; diethyl ether / -10 - 20 °C 5.1: PhCO2Ag; Et3N / -25 - 20 °C View Scheme

D-lysine hydrochloride (7274-88-6) → (S)-2-[((2R,3R)-3-Benzyloxycarbonylamino-7-hydroxy-2-methyl-heptanoyl)-methyl-amino]-3-methyl-butyric acid methyl ester

Conditions

Yield

Multi-step reaction with 11 steps 1.1: aq. LiOH / 0 °C 2.1: aq. NaOH / ethanol / 0.33 h / -10 - 20 °C 2.2: HCl / ethanol / 0.17 h / 50 °C 3.1: NaNO2; AcOH / 6 h / 40 °C 4.1: Et3N; isobutyl chloroformate / tetrahydrofuran / 1 h / -25 - -10 °C 4.2: tetrahydrofuran; diethyl ether / -10 - 20 °C 5.1: PhCO2Ag; Et3N / -25 - 20 °C 6.1: K2CO3 / methanol / 6 h / 0 °C 7.1: iPr2NEt / CH2Cl2 / 5 h / 20 °C 8.1: LDA; LiCl / tetrahydrofuran / -78 °C 9.1: LiOH*H2O / tetrahydrofuran; methanol; H2O / 0 - 20 °C 10.1: iPr2NEt; 1-hydroxy-7-azabenzotriazole; 2-bromo-1-ethylpyridinium tetrafluoroborate / CH2Cl2 / -25 - 20 °C 11.1: TFA / CH2Cl2 / 0 °C View Scheme

D-lysine hydrochloride (7274-88-6) → (R)-3-Benzyloxycarbonylamino-7-(2-trimethylsilanyl-ethoxymethoxy)-heptanoic acid methyl ester

Conditions

Yield

Multi-step reaction with 7 steps 1.1: aq. LiOH / 0 °C 2.1: aq. NaOH / ethanol / 0.33 h / -10 - 20 °C 2.2: HCl / ethanol / 0.17 h / 50 °C 3.1: NaNO2; AcOH / 6 h / 40 °C 4.1: Et3N; isobutyl chloroformate / tetrahydrofuran / 1 h / -25 - -10 °C 4.2: tetrahydrofuran; diethyl ether / -10 - 20 °C 5.1: PhCO2Ag; Et3N / -25 - 20 °C 6.1: K2CO3 / methanol / 6 h / 0 °C 7.1: iPr2NEt / CH2Cl2 / 5 h / 20 °C View Scheme

D-lysine hydrochloride (7274-88-6) → (2R,3R)-3-Benzyloxycarbonylamino-2-methyl-7-(2-trimethylsilanyl-ethoxymethoxy)-heptanoic acid methyl ester (790302-28-2)

Conditions

Yield

Multi-step reaction with 8 steps 1.1: aq. LiOH / 0 °C 2.1: aq. NaOH / ethanol / 0.33 h / -10 - 20 °C 2.2: HCl / ethanol / 0.17 h / 50 °C 3.1: NaNO2; AcOH / 6 h / 40 °C 4.1: Et3N; isobutyl chloroformate / tetrahydrofuran / 1 h / -25 - -10 °C 4.2: tetrahydrofuran; diethyl ether / -10 - 20 °C 5.1: PhCO2Ag; Et3N / -25 - 20 °C 6.1: K2CO3 / methanol / 6 h / 0 °C 7.1: iPr2NEt / CH2Cl2 / 5 h / 20 °C 8.1: LDA; LiCl / tetrahydrofuran / -78 °C View Scheme

D-lysine hydrochloride (7274-88-6) → (2R,3R)-3-Benzyloxycarbonylamino-2-methyl-7-(2-trimethylsilanyl-ethoxymethoxy)-heptanoic acid

Conditions

Yield

Multi-step reaction with 9 steps 1.1: aq. LiOH / 0 °C 2.1: aq. NaOH / ethanol / 0.33 h / -10 - 20 °C 2.2: HCl / ethanol / 0.17 h / 50 °C 3.1: NaNO2; AcOH / 6 h / 40 °C 4.1: Et3N; isobutyl chloroformate / tetrahydrofuran / 1 h / -25 - -10 °C 4.2: tetrahydrofuran; diethyl ether / -10 - 20 °C 5.1: PhCO2Ag; Et3N / -25 - 20 °C 6.1: K2CO3 / methanol / 6 h / 0 °C 7.1: iPr2NEt / CH2Cl2 / 5 h / 20 °C 8.1: LDA; LiCl / tetrahydrofuran / -78 °C 9.1: LiOH*H2O / tetrahydrofuran; methanol; H2O / 0 - 20 °C View Scheme

D-lysine hydrochloride (7274-88-6) → (S)-2-{[(2R,3R)-3-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyrylamino)-2-methyl-7-oxo-heptanoyl]-methyl-amino}-3-methyl-butyric acid methyl ester

Conditions

Yield

Multi-step reaction with 14 steps 1.1: aq. LiOH / 0 °C 2.1: aq. NaOH / ethanol / 0.33 h / -10 - 20 °C 2.2: HCl / ethanol / 0.17 h / 50 °C 3.1: NaNO2; AcOH / 6 h / 40 °C 4.1: Et3N; isobutyl chloroformate / tetrahydrofuran / 1 h / -25 - -10 °C 4.2: tetrahydrofuran; diethyl ether / -10 - 20 °C 5.1: PhCO2Ag; Et3N / -25 - 20 °C 6.1: K2CO3 / methanol / 6 h / 0 °C 7.1: iPr2NEt / CH2Cl2 / 5 h / 20 °C 8.1: LDA; LiCl / tetrahydrofuran / -78 °C 9.1: LiOH*H2O / tetrahydrofuran; methanol; H2O / 0 - 20 °C 10.1: iPr2NEt; 1-hydroxy-7-azabenzotriazole; 2-bromo-1-ethylpyridinium tetrafluoroborate / CH2Cl2 / -25 - 20 °C 11.1: TFA / CH2Cl2 / 0 °C 12.1: aq. HCl; H2 / Pd/C / methanol / 20 °C 13.1: HOBt; EDCI; N-methylmorpholine / CH2Cl2 / 0 - 20 °C 14.1: DMSO; oxalyl chloride; iPr2NEt / CH2Cl2 / -78 - -55 °C View Scheme

D-lysine hydrochloride (7274-88-6) → (S)-2-[((2R,3R)-3-Amino-7-hydroxy-2-methyl-heptanoyl)-methyl-amino]-3-methyl-butyric acid methyl ester; hydrochloride

Conditions

Yield

Multi-step reaction with 12 steps 1.1: aq. LiOH / 0 °C 2.1: aq. NaOH / ethanol / 0.33 h / -10 - 20 °C 2.2: HCl / ethanol / 0.17 h / 50 °C 3.1: NaNO2; AcOH / 6 h / 40 °C 4.1: Et3N; isobutyl chloroformate / tetrahydrofuran / 1 h / -25 - -10 °C 4.2: tetrahydrofuran; diethyl ether / -10 - 20 °C 5.1: PhCO2Ag; Et3N / -25 - 20 °C 6.1: K2CO3 / methanol / 6 h / 0 °C 7.1: iPr2NEt / CH2Cl2 / 5 h / 20 °C 8.1: LDA; LiCl / tetrahydrofuran / -78 °C 9.1: LiOH*H2O / tetrahydrofuran; methanol; H2O / 0 - 20 °C 10.1: iPr2NEt; 1-hydroxy-7-azabenzotriazole; 2-bromo-1-ethylpyridinium tetrafluoroborate / CH2Cl2 / -25 - 20 °C 11.1: TFA / CH2Cl2 / 0 °C 12.1: aq. HCl; H2 / Pd/C / methanol / 20 °C View Scheme

D-lysine hydrochloride (7274-88-6) → (S)-2-{[(2R,3R)-3-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyrylamino)-7-hydroxy-2-methyl-heptanoyl]-methyl-amino}-3-methyl-butyric acid methyl ester (790302-31-7)

Conditions

Yield

Multi-step reaction with 13 steps 1.1: aq. LiOH / 0 °C 2.1: aq. NaOH / ethanol / 0.33 h / -10 - 20 °C 2.2: HCl / ethanol / 0.17 h / 50 °C 3.1: NaNO2; AcOH / 6 h / 40 °C 4.1: Et3N; isobutyl chloroformate / tetrahydrofuran / 1 h / -25 - -10 °C 4.2: tetrahydrofuran; diethyl ether / -10 - 20 °C 5.1: PhCO2Ag; Et3N / -25 - 20 °C 6.1: K2CO3 / methanol / 6 h / 0 °C 7.1: iPr2NEt / CH2Cl2 / 5 h / 20 °C 8.1: LDA; LiCl / tetrahydrofuran / -78 °C 9.1: LiOH*H2O / tetrahydrofuran; methanol; H2O / 0 - 20 °C 10.1: iPr2NEt; 1-hydroxy-7-azabenzotriazole; 2-bromo-1-ethylpyridinium tetrafluoroborate / CH2Cl2 / -25 - 20 °C 11.1: TFA / CH2Cl2 / 0 °C 12.1: aq. HCl; H2 / Pd/C / methanol / 20 °C 13.1: HOBt; EDCI; N-methylmorpholine / CH2Cl2 / 0 - 20 °C View Scheme

D-lysine hydrochloride (7274-88-6) → (S)-2-{[(2R,3R)-3-Benzyloxycarbonylamino-2-methyl-7-(2-trimethylsilanyl-ethoxymethoxy)-heptanoyl]-methyl-amino}-3-methyl-butyric acid methyl ester (790302-29-3)

Conditions

Yield

Multi-step reaction with 10 steps 1.1: aq. LiOH / 0 °C 2.1: aq. NaOH / ethanol / 0.33 h / -10 - 20 °C 2.2: HCl / ethanol / 0.17 h / 50 °C 3.1: NaNO2; AcOH / 6 h / 40 °C 4.1: Et3N; isobutyl chloroformate / tetrahydrofuran / 1 h / -25 - -10 °C 4.2: tetrahydrofuran; diethyl ether / -10 - 20 °C 5.1: PhCO2Ag; Et3N / -25 - 20 °C 6.1: K2CO3 / methanol / 6 h / 0 °C 7.1: iPr2NEt / CH2Cl2 / 5 h / 20 °C 8.1: LDA; LiCl / tetrahydrofuran / -78 °C 9.1: LiOH*H2O / tetrahydrofuran; methanol; H2O / 0 - 20 °C 10.1: iPr2NEt; 1-hydroxy-7-azabenzotriazole; 2-bromo-1-ethylpyridinium tetrafluoroborate / CH2Cl2 / -25 - 20 °C View Scheme

D-lysine hydrochloride (7274-88-6) → (R)-6-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoic acid (55878-47-2)

Conditions	Yield
Multi-step reaction with 2 steps 1: 1.) basic copper carbonate, 2.) NaOH / 1.) H2O, reflux, 2.5 h, 2.) RT, overnight 2: 91 percent / aq. NaOH / 2-methyl-propan-2-ol / Ambient temperature View Scheme

D-lysine hydrochloride (7274-88-6) → Boc-D-Lys-OH (106719-44-2)

Conditions	Yield
Multi-step reaction with 3 steps 1: 1.) basic copper carbonate, 2.) NaOH / 1.) H2O, reflux, 2.5 h, 2.) RT, overnight 2: 91 percent / aq. NaOH / 2-methyl-propan-2-ol / Ambient temperature 3: H2 / 5percent Pd/C / methanol; H2O / 24 h / 2585.7 Torr View Scheme

D-lysine hydrochloride (7274-88-6) → Nα-tert-butyloxycarbonyl-Nε-nicotinoyl-D-lysine (122546-52-5)

Conditions	Yield
Multi-step reaction with 4 steps 1: 1.) basic copper carbonate, 2.) NaOH / 1.) H2O, reflux, 2.5 h, 2.) RT, overnight 2: 91 percent / aq. NaOH / 2-methyl-propan-2-ol / Ambient temperature 3: H2 / 5percent Pd/C / methanol; H2O / 24 h / 2585.7 Torr 4: dimethylformamide / 120 h / Ambient temperature View Scheme

(9H-fluoren-9-yl)methyl azidoformate (28920-44-7) + D-lysine hydrochloride (7274-88-6) → N,N'-bis-(9-fluorenylmethyloxycarbonyl)-D-lysine (75932-02-4)

Conditions	Yield
In hexane; water; sodium carbonate; acetone

benzyl bromide (100-39-0) + D-lysine hydrochloride (7274-88-6) → (R)-benzyl 2,6-bis(dibenzylamino)hexanoate

Conditions	Yield
Stage #1: benzyl bromide; D-lysine hydrochloride With potassium carbonate In ethanol at 60℃; for 96h; Stage #2: In ethanol

D-lysine hydrochloride (7274-88-6) → C26H30F6N2O5

Conditions	Yield
Multi-step reaction with 2 steps 1.1: sulfuric acid / water / 20 - 30 °C 1.2: 120 °C / 36228.6 Torr / Autoclave; Sealed tube 2.1: N-ethyl-N,N-diisopropylamine / dichloromethane-d2 / 2 h / 20 °C View Scheme

Upstream product

• 6804-88-2 α-nitrocaprolactam 
• 70-53-1 2,6-Diamino-hexanoic acid; hydrochloride 
• 923-27-3 D-lysine 

Downstream Products

• 31202-69-4 N_ε-(tert-butoxycarbonyl)-D-lysine 
• 70-53-1 2,6-Diamino-hexanoic acid; hydrochloride 
• 132718-70-8 Boc-D-Har(NO2)-OH 
• 17929-90-7 3-aminoazepan-2-one 
• 1023970-50-4 C₁₆H₂₃IN₂O₃ 
• 106691-72-9 3(R)--2-oxoperhydroazepine 
• 110690-36-3 L-lysinol 
• 75932-02-4 N,N'-bis-(9-fluorenylmethyloxycarbonyl)-D-lysine 
• 122546-52-5 N^α-tert-butyloxycarbonyl-N^ε-nicotinoyl-D-lysine 
• 106719-44-2 Boc-D-Lys-OH 
• 55878-47-2 (R)-6-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoic acid 
• 118812-46-7 DPAB-D-Lys (cis) 
• 790302-29-3 (S)-2-{[(2R,3R)-3-Benzyloxycarbonylamino-2-methyl-7-(2-trimethylsilanyl-ethoxymethoxy)-heptanoyl]-methyl-amino}-3-methyl-butyric acid methyl ester 
• 790302-28-2 (2R,3R)-3-Benzyloxycarbonylamino-2-methyl-7-(2-trimethylsilanyl-ethoxymethoxy)-heptanoic acid methyl ester 

Relevant articles and documents

Chiral Receptors for Lysine Based on Covalently Linked Bis- and Tris-binaphthylphosphoric Acids

The synthesis and application of three chiral receptors based on the covalent linkage of 1,1′-binaphthylphosphoric acids is reported. The binding of the lysine enantiomers to the chiral receptors was investigated by DOSY-NMR and NMR titrations, revealing that the bisphosphoric acid 1d acts as a highly stereoselective receptor for binding of d-lysine.