318466-95-4Relevant articles and documents
Efficient macrocyclization by means of 2-nitrobenzenesulfonamide and total synthesis of lipogrammistin-A
Kan, Toshiyuki,Fujiwara, Akiko,Kobayashi, Hideki,Fukuyama, Tohru
, p. 6267 - 6276 (2007/10/03)
Synthesis of medium- and large-sized cyclic amines using alkylation with 2-nitrobenzenesulfonamides is described. Using either conventional alkylation procedures or Mitsunobu conditions, the cyclization reaction proceeded in a highly efficient manner. The usefulness of this methodology has been fully demonstrated in the total synthesis of lipogrammistin-A (9), an 18-membered cyclic polyamine.