5840-01-7Relevant articles and documents
Straight Access to Indoles from Anilines and Ethylene Glycol by Heterogeneous Acceptorless Dehydrogenative Condensation
Llabres-Campaner, Pedro Juan,Ballesteros-Garrido, Rafael,Ballesteros, Rafael,Abarca, Belén
, p. 521 - 526 (2018/01/01)
The development of original strategies for the preparation of indole derivatives is a major goal in drug design. Herein, we report the first straight access to indoles from anilines and ethylene glycol by heterogeneous catalysis, based on an acceptorless dehydrogenative condensation, under noninert conditions. In order to achieve high selectivity, a combination of Pt/Al2O3 and ZnO have been found to slowly dehydrogenate ethylene glycol generating, after condensation with the amine and tautomeric equilibrium, the corresponding pyrrole-ring unsubstituted indoles.
Heterogeneous borrowing hydrogen reactions with Pd/C and ZnO: Diol scope
Llabres-Campaner, Pedro J.,Woodbridge-Ortega, Patricia,Ballesteros-Garrido, Rafael,Ballesteros, Rafael,Abarca, Belén
supporting information, p. 4880 - 4882 (2017/11/29)
A borrowing hydrogen reaction with different diols was employed for the preparation of complex beta- gamma- or epsilon-amino alcohols from p-toluidine and tetrahydroquinoline with the aim of better understanding the applicability of the Pd/C ZnO heterogeneous catalyst.
COMBINATIONAL COMPOSITIONS AND METHODS FOR TREATMENT OF CANCER
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, (2015/12/23)
The present invention provides methods of treating a cell proliferative disorder, such as a cancer, by administering to a subject in need thereof a therapeutically effective amount of a pyrroloquinolinyl-pyrrole-2,5-dione compound or a pyrroloquinolinyl-pyrrolidine-2,5-dione compound in combination with a therapeutically effective amount of a second anti-proliferative agent.