2-METHOXYESTRADIOL CAS NO.362-07-2

Min.Order Quantity:: 1 Kilogram

Purity:: 99%

Port:: Shanghai/Tianjin/Qingdao

Payment Terms:: L/C,D/A,D/P,T/T,

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Product Details

Keywords

2,3,17BETA-TRIHYDROXY-1,3,5[10]-ESTRATRIENE 2-METHYL ETHER
3,17BETA-DIHYDROXY-2-METHOXY-1,3,5[10]-ESTRATRIENE
2-METHOXY-3,17BETA-DIHYDROXYESTRA-1,3,5(10)-TRIENE

Quick Details

ProName: 2-METHOXYESTRADIOL
CasNo: 362-07-2
Molecular Formula: C19H26O3
Appearance: Off-White Solid
Application: 362-07-2
DeliveryTime: 7-10 days after payment
PackAge: As required
Port: Shanghai/Tianjin/Qingdao
ProductionCapacity: 100-200 Kilogram/Month
Purity: 99%
Storage: ?20°C
Transportation: By air/sea/express
LimitNum: 1 Kilogram
Grade: Pharma Grade

Superiority

about certificate

1.certificate of analysis (coa)
2.material safety data sheet (msds)
3.route of synthesis (ros)
4.method of aanlysis(moa)
5.nuclear magnetic resonance(nmr)

about service

1. quality control, before shipment, free sample for test.
2. prompt shipment with professional documents
3. packing as your request, with photo before shipment
4. mixed containers with different mixed items in one container

about company

hennan sunlake enterprise corporation is located in henan province , the central plain of china , which enjoys favorable geogeaphical position and convenient transportion, the com[any was established in june. 1998 , until now having more than 18 years experience in manufacturing & exporting chemical raw material .

sunlake is a professional manufacturer engaged in producing and selling chemicals,including organic & inorganic chemicals , pigments & dyestuffs , water treatment chemicals , food & feed additives and others . these products have been being well exported to europe , southeast asia , the middle east , africa , south america and some other countries and areas.

we sincerely welcome foreign friends to visit our plant for cooperation. with the idea of "quality first,credit priority, excellent service", we are highly acknowledged by customers for good quality and competitive price. more importantly , the company has a strong r & d team, who are professional engineers and scholars with ph. d. .so we are confident to serve you better with our high - quality products and professional team.

we are taking great efforts to provide our customers with demanded goods and professional services, and continuously improve our core ability of competition and get the momentum for sustainable development, and finally make us being a reliable and professional wupplier in international market.

we welcome any serious inquiries from all customers of the world, and sincerely hope to cooperate with you for a brilliant future!

Details

product name:	2-methoxyestradiol
synonyms:	2,3,17beta-trihydroxy-1,3,5[10]-estratriene 2-methyl ether;3,17beta-dihydroxy-2-methoxy-1,3,5[10]-estratriene;2-methoxy-3,17beta-dihydroxyestra-1,3,5(10)-triene;2-methoxy-estra-1,3,5(10)-triene-3,17beta-diol;2-methoxyestradiol;1,3,5(10)-estratriene-2,3,17beta-triol 2-methyl ether;1,3,5[10]-estratriene-2,3,17-triol 2-methyl ether;1,3,5(10)-estratrien-2,3,17-beta-triol 2-methyl ether
cas:	362-07-2
mf:	c19h26o3
mw:	302.41
einecs:
product categories:	intermediates & fine chemicals;metabolites & impurities;pharmaceuticals;steroids;inhibitor;2-me2;isolabel;inhibitors
mol file:	362-07-2.mol

2-methoxyestradiol chemical properties

mp	188-190°c
storage temp.	−20°c
solubility	dmso: 10 mg/ml
form	crystalline
color	light yellow
cas database reference	362-07-2(cas database reference)

safety information

hazard codes	t,xi,n
risk statements	23/24/25-36/37/38-48-61-60-46-45-51/53
safety statements	22-26-36/37/39-45-53-36-61
ridadr	un 3077 9/pg 3
wgk germany	3
rtecs	kg7537500

msds information

provider	language
sigmaaldrich	english

2-methoxyestradiol usage and synthesis

chemical properties	off-white solid
usage	a natural metabolite of 17 estradiol which is devoid of estrogenic activity. inhibits cell proliferation and angiogenesis. binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule a
usage	a natural metabolite of 17β-estradiol which is devoid of estrogenic activity. inhibits cell proliferation and angiogenesis. binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule assembly
usage	2-methoxyestradiol is a tubulin polymerization inhibitor and also decreases hif-1 activity.
usage	2-methoxyestradiol depolymerizes microtubules and blocks hif-1α nuclear accumulation and hif-transcriptional activity. phase 2.
usage	2-methoxy 17β-estradiol is a natural metabolite of 17β-estradiol which is devoid of estrogenic activity. inhibits cell proliferation and angiogenesis. 2-methoxy 17β-estradiol binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule assembly and function.
biological activity	apoptotic, antiproliferative and antiangiogenic agent, in vitro and in vivo ; acts via an estrogen receptor-independent mechanism. induces p53-induced apoptosis via two pathways: activation of p38 and nf- κ b; and activation of jnk and ap-1 leading to bcl-2 phosphorylation. also upregulates death receptor 5 and binds to tubulin, inhibiting its assembly.