Nateglinide CAS NO.105816-04-4

Min.Order Quantity:: 1 Kilogram

Purity:: 99%

Port:: Shanghai/Tianjin/Qingdao

Payment Terms:: L/C,D/A,D/P,T/T,

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Product Details

Keywords

(-)-n-(trans-4-isopropylcyclohexanecarbonyl)-d-phenylalanine
ay4166
Nateglinide(H)

Quick Details

ProName: Nateglinide
CasNo: 105816-04-4
Molecular Formula: C19H27NO3
Appearance: Cyrstalline Solid
Application: 105816-04-4 ...
DeliveryTime: 7-10 days after payment
PackAge: As required
Port: Shanghai/Tianjin/Qingdao
ProductionCapacity: 100-200 Kilogram/Month
Purity: 99%
Storage: Room temp
Transportation: By air/sea/express
LimitNum: 1 Kilogram
Grade: Pharma Grade

Superiority

about certificate

1.certificate of analysis (coa)
2.material safety data sheet (msds)
3.route of synthesis (ros)
4.method of aanlysis(moa)
5.nuclear magnetic resonance(nmr)

about service

1. quality control, before shipment, free sample for test.
2. prompt shipment with professional documents
3. packing as your request, with photo before shipment
4. mixed containers with different mixed items in one container

about company

hennan sunlake enterprise corporation is located in henan province , the central plain of china , which enjoys favorable geogeaphical position and convenient transportion, the com[any was established in june. 1998 , until now having more than 18 years experience in manufacturing & exporting chemical raw material .

sunlake is a professional manufacturer engaged in producing and selling chemicals,including organic & inorganic chemicals , pigments & dyestuffs , water treatment chemicals , food & feed additives and others . these products have been being well exported to europe , southeast asia , the middle east , africa , south america and some other countries and areas.

we sincerely welcome foreign friends to visit our plant for cooperation. with the idea of "quality first,credit priority, excellent service", we are highly acknowledged by customers for good quality and competitive price. more importantly , the company has a strong r & d team, who are professional engineers and scholars with ph. d. .so we are confident to serve you better with our high - quality products and professional team.

we are taking great efforts to provide our customers with demanded goods and professional services, and continuously improve our core ability of competition and get the momentum for sustainable development, and finally make us being a reliable and professional wupplier in international market.

we welcome any serious inquiries from all customers of the world, and sincerely hope to cooperate with you for a brilliant future!

Details

product name:	nateglinide
synonyms:	(-)-n-(trans-4-isopropylcyclohexanecarbonyl)-d-phenylalanine;ay4166;nateglinide(h);trans-d-phenylalanin;trans-n-((4-(1-methylethyl)cyclohexyl)carbonyl)-d-phenylalanine;3-phenyl-2-(4-propan-2-ylcyclohexyl)carbonylamino-propanoic acid;a-4166;starlix
cas:	105816-04-4
mf:	c19h27no3
mw:	317.42
einecs:
product categories:	active pharmaceutical ingredients;api;apis;health & beauty;amino acids & derivatives;intermediates & fine chemicals;pharmaceuticals;aromatics;starlix;antidiabetic
mol file:	105816-04-4.mol

nateglinide chemical properties

mp	137-141°c
storage temp.	room temp
cas database reference	105816-04-4(cas database reference)

safety information

hazard codes	xn
risk statements	22
safety statements	24/25-36
rtecs	sq7318950

msds information

provider	language
nateglinide	english

nateglinide usage and synthesis

physical and chemical properties	white or almost white crystalline powder, odorless, bitter taste. it is soluble in methanol, ethanol, chloroform, dissolved in acetone, ethyl ether, almost insoluble in water. valid form used in clinic is h- type, mp 137 ~ 141 ℃. [α] d-37.5 °, the maximum uv absorption wavelength in methanol is 252,257,263nm. the above information is edited by the chemicalbook of tian ye.
hypoglycemic agents	nateglinide and mitiglinide, repaglinide are three commonly used non-sulfonylurea oral hypoglycemic agents for insulin secretion,it is successfully developed for the first time by the japanese company ajomoto , its chemical structure belongs to carbamoylmethyl-benzoic acid (cmba), it belongs to d- phenylalanine derivatives, it is a new generation of antidiabetic drugs having amino acid structure ,it is an amino acid derivative prompting insulin secretion, it is also currently the only non-sulfonylureas insulinotropic agent having amino acid structure. the mechanism is mainly through binding the pancreatic β cell sulfonylurea receptor, blocking islet cell atp-sensitive potassium channels, leading to membrane depolarization, causing the calcium channe lopen to promote insulin secretion. this product is a new type of meal blood glucose regulator, which can effectively control the postprandial blood glucose levels, with rapid onset, short duration of action, low incidence of cardiovascular side effects and hypoglycemia and other characteristics. oral bioavailability is 72%, after 15min it can produce insulin secretion effect, tmax is 0.5 ~ 0.9 h, 0.2 h insulin levels achieve peak ,after 1.5 h it is similar to placebo. the plasma protein binding rate is 99%. after reaching plasmapeak , plasma concentrations decline rapidly.t1 / 2 of oral administration of 120 mg and intravenous injection 60 mg of is 1.5 to 1.7 hours, and the plasma clearance is 7.4 hours. it is metabolized in the liver by isoenzyme cyp2c9 and cyp3a4 way. the main metabolites are products after isomeric oxidation,it can be hydroxyl, diastereomers, isopropyl isomer or unsaturated aliphatic isomers.the main metabolites in plasma and urine are metabolites after the hydroxylation of isopropyl methine family (me-thine carbon) . about 2/3 nateglinide is excreted from the fecal , and the rest is excreted in the urine. such excretion way is beneficial to elderly ⅱ diabetes mellitus with renal dysfunction. nateglinide eliminate t1 / 2 is 1.4 h, because nateglinide t1 / 2 is short, there is no report yet about the drug accumulation in the body . long-term use of nateglinide does not produce drug-induced hypoglycemia caused by drug accumulation .it is used for the treatment of diet therapy, exercise therapy and mild to moderate non-insulin dependent (ⅱ type) diabetes which taking α- glucosidase inhibitor can not control. the results show that: nateglinide can be used more physiologically for meal glucose control, there is less opportunity for contact with insulin and hypoglycemia which allows patients to flexibly plan scheduling mealtimes, which means there is medication while eating, not eating no medication.
application	it is used for the treatment of diabetes
chemical properties	cyrstalline solid
usage	antidiabetic katp channel blocker
usage	an amino-acid derivative that stimulates insulin secretion. used as an antidiabetic