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(1S,2S)-(+)-trans-1-Amino-2-indanol

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Name

(1S,2S)-(+)-trans-1-Amino-2-indanol

EINECS 604-604-1
CAS No. 163061-74-3 Density 1.212 g/cm3
PSA 46.25000 LogP 1.30370
Solubility N/A Melting Point 142-146 °C
Formula C9H11NO Boiling Point 290 °C at 760 mmHg
Molecular Weight 149.192 Flash Point 129.2 °C
Transport Information N/A Appearance N/A
Safety 26-36 Risk Codes 36/37/38
Molecular Structure Molecular Structure of 163061-74-3 ((1S,2S)-(+)-trans-1-Amino-2-indanol) Hazard Symbols IrritantXi
Synonyms

(1S,2S)-1-Aminoindan-2-ol;(1S,2S)-1-Amino-2,3-dihydro-1H-inden-2-ol;

Article Data 14

(1S,2S)-(+)-trans-1-Amino-2-indanol Synthetic route

438051-03-7

tert-butyl ((1S,2S)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)carbamate

163061-74-3

(1S,2S)-1-amino-2,3-dihydro-1H-inden-2-ol

Conditions
ConditionsYield
With hydrogenchloride In methanol; water at 0 - 20℃; Inert atmosphere;100%

C16H17NO

163061-74-3

(1S,2S)-1-amino-2,3-dihydro-1H-inden-2-ol

Conditions
ConditionsYield
With 5%-palladium/activated carbon; hydrogen In methanol at 60 - 65℃; under 6000.6 Torr;93%
768-22-9, 67528-26-1, 71214-81-8, 85354-35-4

(1aR,6aS)-6,6a-dihydro-1aH-indeno[1,2-b]oxirene

163061-74-3

(1S,2S)-1-amino-2,3-dihydro-1H-inden-2-ol

Conditions
ConditionsYield
With ammonium hydroxide81%
Multi-step reaction with 2 steps
1: 70 percent / NaN3
2: 60 percent / LiAlH4
View Scheme
With ammonia In water at 20℃; for 5h; Inert atmosphere;0.57 g
67528-24-9

trans-2-bromo-2,3-dihydro-1H-inden-1-ol

163061-74-3

(1S,2S)-1-amino-2,3-dihydro-1H-inden-2-ol

Conditions
ConditionsYield
With ammonia In water at 0℃; for 24.5h;69%
180467-85-0

(1S,2S)-1-azido-2,3-dihydro-1H-inden-2-ol

163061-74-3

(1S,2S)-1-amino-2,3-dihydro-1H-inden-2-ol

Conditions
ConditionsYield
With lithium aluminium tetrahydride60%
163061-74-3

(1S,2S)-1-amino-2,3-dihydro-1H-inden-2-ol

24424-99-5

di-tert-butyl dicarbonate

163061-74-3

(1S,2S)-1-amino-2,3-dihydro-1H-inden-2-ol

438051-03-7

tert-butyl ((1S,2S)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)carbamate

Conditions
ConditionsYield
With sodium carbonate In tetrahydrofuran; water at 0 - 20℃; for 3h;100%
With sodium carbonate In tetrahydrofuran; water at 0 - 20℃; for 3h;100%
With triethylamine In methanol at 20℃; for 48h;98%
23165-29-9

3,5-bistrifluoromethylphenylisothiocyanate

163061-74-3

(1S,2S)-1-amino-2,3-dihydro-1H-inden-2-ol

1210360-56-7

1-[3,5-bis(trifluoromethyl)phenyl]-3-[(1S,2S)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]thiourea

Conditions
ConditionsYield
In dichloromethane at 20℃; for 18h;100%
50-00-0

formaldehyd

163061-74-3

(1S,2S)-1-amino-2,3-dihydro-1H-inden-2-ol

272119-19-4

(1S,2S)-1-dimethylamino-2-indanol

Conditions
ConditionsYield
With formic acid In water at 95℃; Inert atmosphere;99%
15761-39-4

1-(tert-butoxycarbonyl)-L-proline

541-41-3

chloroformic acid ethyl ester

163061-74-3

(1S,2S)-1-amino-2,3-dihydro-1H-inden-2-ol

(S)-tert-butyl 2-((1S,2 S)-2-hydroxy-2,3-dihydro-1H-inden-1-ylcarbamoyl)pyrrolidine-1-carboxylate

Conditions
ConditionsYield
With 4-methyl-morpholine In ethyl acetate99%

(1S,2S)-(+)-trans-1-Amino-2-indanol Specification

The (1S,2S)-(+)-trans-1-Amino-2-indanol, with the CAS registry number of 163061-74-3, is also known as (1S,2S)-1-Aminoindan-2-ol. It belongs to the product categories of Amino Alcohols; Chiral Building Blocks; Organic Building Blocks. This chemical's molecular formula is C9H11NO and molecular weight is 149.19. What's more, its IUPAC name is (1S,2S)-1-Amino-2,3-dihydro-1H-inden-2-ol.

Physical properties about (1S,2S)-(+)-trans-1-Amino-2-indanol are: (1)ACD/LogP: 0.43; (2)# of Rule of 5 Violations: 0; (3)#H bond acceptors: 2; (4)#H bond donors: 3; (5)#Freely Rotating Bonds: 2; (6)Polar Surface Area: 12.47 Å2; (7)Index of Refraction: 1.626; (8)Molar Refractivity: 43.57 cm3; (9)Molar Volume: 123 cm3; (10)Polarizability: 17.27×10-24 cm3; (11)Surface Tension: 51.7 dyne/cm; (12)Density: 1.212 g/cm3; (13)Flash Point: 129.2 °C; (14)Enthalpy of Vaporization: 55.91 kJ/mol; (15)Boiling Point: 290 °C at 760 mmHg; (16)Vapour Pressure: 0.000978 mmHg at 25 °C.

When you are using this chemical, please be cautious about it as the following:
As a chemical, it is irritating to eyes, respiratory system and skin. In addition, this chemical may cause inflammation to the skin or other mucous membranes. During using it, wear suitable protective clothing. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1) SMILES: O[C@H]2Cc1ccccc1[C@@H]2N
(2) InChI: InChI=1/C9H11NO/c10-9-7-4-2-1-3-6(7)5-8(9)11/h1-4,8-9,11H,5,10H2/t8-,9-/m0/s1
(3) InChIKey: LOPKSXMQWBYUOI-IUCAKERBBK

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