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(R)-(+)-1-Amino-2-(methoxymethyl)pyrrolidine

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Name

(R)-(+)-1-Amino-2-(methoxymethyl)pyrrolidine

EINECS N/A
CAS No. 72748-99-3 Density 0.991 g/cm3
PSA 38.49000 LogP 0.60910
Solubility N/A Melting Point N/A
Formula C6H14N2O Boiling Point 183.7 °C at 760 mmHg
Molecular Weight 130.19 Flash Point 64.9 °C
Transport Information N/A Appearance Colorless to light yellow liquid
Safety 26-36-24/25 Risk Codes 36/37/38
Molecular Structure Molecular Structure of 72748-99-3 ((R)-(+)-1-AMINO-2-(METHOXYMETHYL)PYRROLIDINE) Hazard Symbols IrritantXi
Synonyms

1-Pyrrolidinamine,2-(methoxymethyl)-, (R)-;(2R)-2-(Methoxymethyl)-1-pyrrolidinamine;(R)-(+)-1-Amino-2-(methoxymethyl)pyrrolidine;(R)-1-Amino-2-methoxymethylpyrrolidine;RAMP;RAMP (chiral auxiliary);[(2R)-2-(Methoxymethyl)pyrrolidin-1-yl]amine;

Article Data 2

(R)-(+)-1-Amino-2-(methoxymethyl)pyrrolidine Specification

The systematic name of (R)-(+)-1-Amino-2-(methoxymethyl)pyrrolidine is (2R)-2-(methoxymethyl)pyrrolidin-1-amine. With the CAS registry number 72748-99-3, it is also named as 1-pyrrolidinamine, 2-(methoxymethyl)-, (2R)-. The product's categories are Pyrrolidine; Chiral; Asymmetric Synthesis; Synthetic Organic Chemistry; Chiral Compound. It is colorless to light yellow liquid which should be sealed in the container and stored in the cool and dry place.

The other characteristics of this product can be summarized as: (1)ACD/LogP: -1.25; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -3.62; (4)ACD/LogD (pH 7.4): -1.91; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1.07; (9)#H bond acceptors: 3; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 3; (12)Polar Surface Area: 15.71 Å2; (13)Index of Refraction: 1.47; (14)Molar Refractivity: 36.63 cm3; (15)Molar Volume: 131.2 cm3; (16)Polarizability: 14.52×10-24 cm3; (17)Surface Tension: 33.1 dyne/cm; (18)Density: 0.991 g/cm3; (19)Flash Point: 64.9 °C; (20)Enthalpy of Vaporization: 41.99 kJ/mol; (21)Boiling Point: 183.7 °C at 760 mmHg; (22)Vapour Pressure: 0.761 mmHg at 25°C.

Uses of (R)-(+)-1-Amino-2-(methoxymethyl)pyrrolidine: It can react with 2-oxo-cyclohexanecarbonitrile to get (2R)-1-((2R/S)-2-cyanocyclohexylideneamino)-2-methoxymethylpyrrolidine. This reaction needs reagent p-TsOH and solvent cyclohexane by heating. The reaction time is 12 hours. The yield is 72%.

When you are using this chemical, please be cautious about it as the following:
It is irritating to eyes, respiratory system and skin. So people should avoid contact with skin and eyes. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. If you want to contact this product, you must wear suitable protective clothing.

People can use the following data to convert to the molecule structure.
1. SMILES:O(C)C[C@@H]1N(N)CCC1
2. InChI:InChI=1/C6H14N2O/c1-9-5-6-3-2-4-8(6)7/h6H,2-5,7H2,1H3/t6-/m1/s1 
3. InChIKey:BWSIKGOGLDNQBZ-ZCFIWIBFBA

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