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Name	1,2,3,9-Tetrahydro-4(H)-carbazol-4-one	EINECS	604-791-9
CAS No.	15128-52-6	Density	1.275 g/cm³
PSA	32.86000	LogP	2.68690
Solubility	N/A	Melting Point	224-226 ºC
Formula	C₁₂H₁₁NO	Boiling Point	386.3 ºC at 760 mmHg
Molecular Weight	185.225	Flash Point	194.5 ºC
Transport Information	N/A	Appearance	white crystal powder
Safety	26-36	Risk Codes	36/37/38
Molecular Structure		Hazard Symbols	Xi
Synonyms	Carbazol-4(1H)-one,2,3-dihydro- (6CI,7CI,8CI);1,2,3,4-Tetrahydrocarbazol-4-one;1,2-Dihydro-4(3H)-carbazolone;2,3-Dihydrocarbazol-4(1H)-one;4-Oxo-1,2,3,4-tetrahydrocarbazole;	Article Data	71

1,2,3,9-Tetrahydro-4(H)-carbazol-4-one Synthetic route

: 85239-68-5
3-[(2-iodophenyl)amino]cyclohex-2-en-1-one

: 15128-52-6
1,2,3,9-tetrahydro-4H-carbazol-4-one

Conditions

Conditions	Yield
With tetrabutyl-ammonium chloride; sodium acetate; tris-(o-tolyl)phosphine; palladium diacetate In N,N-dimethyl-formamide at 100℃; for 0.5h; Heck reaction; Irradiation;	95%
With potassium hydroxide; copper(l) iodide; L-proline In dimethyl sulfoxide at 90℃; for 24h;	92%
With cyclodextrin-grafted silica-supported Pd nanoparticles at 100℃; for 1h; Heck Reaction; Green chemistry;	85%

: 1172640-24-2
methyl 6-(2-nitrophenyl)-5-oxohexanoate

: 15128-52-6
1,2,3,9-tetrahydro-4H-carbazol-4-one

Conditions

Conditions	Yield
With hydrogenchloride; iron In water at 110℃; for 0.333333h; Inert atmosphere;	92%

: 942-01-8
1,2,3,4-tetrahydrocarbazole

: 15128-52-6
1,2,3,9-tetrahydro-4H-carbazol-4-one

Conditions

Conditions	Yield
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In tetrahydrofuran; water at 0℃;	91%
With nitrosonium perchlorate In water; acetonitrile for 1h;	79%
With 2,2,6,6-tetramethylpiperidine-1-oxoammonium tetrafluoroborate In water; acetonitrile for 1h; Mechanism; Product distribution; other indole derivatives and nitrosonium salts, var. solvents;	71%

: N-hydroxytetrahydro-4H-carbazol-4-one

: 15128-52-6
1,2,3,9-tetrahydro-4H-carbazol-4-one

Conditions

Conditions	Yield
With hydrogenchloride; titanium(III) chloride In acetone at 22℃; for 16h; Reagent/catalyst; Temperature; Solvent;	91%

: 128266-89-7
cyclohexane-1,3-dione monophenylhydrazone

: 15128-52-6
1,2,3,9-tetrahydro-4H-carbazol-4-one

Conditions

Conditions	Yield
With trifluoroacetic acid In acetic acid for 3h; Heating;	90%

: 3-amino-2-phenylcyclohex-2-en-1-one

: 15128-52-6
1,2,3,9-tetrahydro-4H-carbazol-4-one

Conditions

Conditions	Yield
With bis-[(trifluoroacetoxy)iodo]benzene In dichloromethane at 20℃; for 0.5h; Cooling with ice;	90%

: C12H14N2O

: 15128-52-6
1,2,3,9-tetrahydro-4H-carbazol-4-one

Conditions

Conditions	Yield
With trifluoroacetic acid for 24h; Reflux; Inert atmosphere;	90%

: 942-01-8
1,2,3,4-tetrahydrocarbazole

A: 15128-52-6
1,2,3,9-tetrahydro-4H-carbazol-4-one

B: 3456-99-3
1-oxo-2,3,4,9-tetrahydrocarbazole

Conditions

Conditions	Yield
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In tetrahydrofuran; water at 0 - 20℃; for 5.5h;	A 89% B 2%

: 59-88-1
phenylhydrazine hydrochloride

: 504-02-9
1,3-cylohexanedione

: 15128-52-6
1,2,3,9-tetrahydro-4H-carbazol-4-one

Conditions

Conditions	Yield
With 1-(3-sulfopropyl)pyridinium p-toluenesulfonate In water at 100℃; for 0.25h;	89%
Stage #1: phenylhydrazine hydrochloride; 1,3-cylohexanedione In acetonitrile at 80 - 85℃; Fischer Indole Synthesis; Stage #2: With hydrogenchloride In water at 90 - 95℃; Fischer Indole Synthesis;	18%

: 29873-09-4
4-(1H-indol-2-yl)butanoic acid

: 15128-52-6
1,2,3,9-tetrahydro-4H-carbazol-4-one

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In water; toluene for 12h; Reflux; Inert atmosphere;	88%

1,2,3,9-Tetrahydro-4(H)-carbazol-4-one Chemical Properties

The Molecular Structure of 1,2,3,9-Tetrahydro-4(H)-carbazol-4-one (CAS NO.15128-52-6):

Systematic Name: 1,2,3,9-Tetrahydro-4H-carbazol-4-one
Empirical Formula: C₁₂H₁₁NO
Molecular Weight: 185.2218
Product Categories: Miscellaneous; (intermediate of carvedilol and ondansetron); Heterocyclic Compounds; Heterocycles
Appearance: white powder
Nominal Mass: 185
Average Mass: 185.2218
Monoisotopic Mass: 185.084064
Index of Refraction: 1.689
Molar Refractivity: 55.44 cm³
Molar Volume: 145.1 cm³
Surface Tension: 59.9 dyne/cm
Density: 1.275 g/cm³
Flash Point: 194.5 °C
Enthalpy of Vaporization: 63.52 kJ/mol
Boiling Point: 386.3 °C at 760 mmHg
Melting Point: 224-226 °C
Vapour Pressure: 3.59E-06 mmHg at 25 °C

1,2,3,9-Tetrahydro-4(H)-carbazol-4-one Uses

It can be used as a carbazole derivative with antimycobacterial activity.

1,2,3,9-Tetrahydro-4(H)-carbazol-4-one Safety Profile

Hazard Codes: Irritant Xi
Risk Statements: 36/37/38
R36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36: Wear suitable protective clothing

1,2,3,9-Tetrahydro-4(H)-carbazol-4-one Specification

1,2,3,9-Tetrahydro-4(H)-carbazol-4-one (CAS NO.15128-52-6) is also called as Rarechem ak ma k053 ; 4-Oxo-1,2,3,4-tetrahydrocarbazole ; 1,2,3,4-Tetrahydro-4h-carbazole-4-one ; 1,2,3,4-Tetrahydro-4-oxo-carbazole ; 1,2,3,4-Tetrahydro-9h-carbazole-4-one ; 1,2,3,9-Tetrahydro-4(h)-carbazol-4-one ; 1,2,3,9-Tetrahydro-9[h]-carbazole-4-one .

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