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1,2,3-Trimethoxybenzene

  • Name 1,2,3-Trimethoxybenzene
  • EINECS211-207-2
  • CAS No. 634-36-6
  • Density1.041 g/cm3
  • PSA27.69000
  • LogP1.71240
  • SolubilityN/A
  • Melting Point43-47 °C(lit.)
  • FormulaC9H12O3
  • Boiling Point235 °C at 760 mmHg
  • Molecular Weight168.192
  • Flash Point70.4 °C
  • Transport InformationN/A
  • Appearancewhite to dark beige powder
  • Safety22-24/25
  • Risk Codes36/37/38
  • Molecular Structure
    Molecular Structure of 634-36-6 (1,2,3-Trimethoxy benzene)
  • Hazard SymbolsN/A
  • SynonymsN/A
  • Article Data100

1,2,3-Trimethoxybenzene Synthetic route

91-10-1

1,3-dimethoxy-2-hydroxy-benzene

616-38-6

carbonic acid dimethyl ester

634-36-6

1,2,3-trimethoxybenzene

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene at 90℃; for 5h; Product distribution; Further Variations:; Temperatures; Solvents; Pressures; reaction times; microwave irradiation;99%
With N,N'-dimethylimidazolium-2-carboxylate In acetonitrile at 160℃; for 1.33333h; Microwave irradiation; Green chemistry;93%
N,N,N',N'-tetrabutyl-N''-methylguanidine at 180℃; for 4.5h;82 % Chromat.
143287-98-3

3,4,5-trimethoxyphenyl trifluoromethanesulfonate

634-36-6

1,2,3-trimethoxybenzene

Conditions
ConditionsYield
With hydrogen; diethylamine; palladium on activated charcoal In methanol at 20℃; for 4h;99%
With ammonium acetate; magnesium; palladium on activated charcoal In methanol at 20℃; for 1h;89%
With methanol; magnesium; palladium on activated charcoal at 20℃; for 12h;
2675-79-8

1-bromo-3,4,5-trimethoxybenzene

634-36-6

1,2,3-trimethoxybenzene

Conditions
ConditionsYield
With potassium hydroxide; iso-butanol; palladium diacetate; triphenylphosphine at 100℃; for 1h;99%
With 4-methyl-morpholine; tetrahydroxydiboron; 5%-palladium/activated carbon In 1,2-dichloro-ethane at 50℃; for 3h;98%
With methanol; gold; hydrogen; caesium carbonate at 100℃; under 3800.26 Torr; for 150h;93%
77-78-1

dimethyl sulfate

87-66-1

2-hydroxyresorcinol

634-36-6

1,2,3-trimethoxybenzene

Conditions
ConditionsYield
Stage #1: 2-hydroxyresorcinol With sodium hydroxide In acetone at 20℃; for 0.5h;
Stage #2: dimethyl sulfate In acetone at 20℃; for 10h;
98%
Stage #1: 2-hydroxyresorcinol With sodium hydroxide at 20℃; for 0.5h;
Stage #2: dimethyl sulfate at 20℃; for 10h;
98%
With sodium hydroxide98%
86-81-7

3,4,5-trimethoxy-benzaldehyde

634-36-6

1,2,3-trimethoxybenzene

Conditions
ConditionsYield
With palladium nanoparticles supported on fibrous silica In cyclohexane at 130℃; Molecular sieve;95%
With hydrogen In tetrahydrofuran at 165℃; under 15001.5 - 26252.6 Torr; for 1.5h; Solvent; Autoclave;90.6%
With palladium diacetate In cyclohexane at 140℃; for 24h; Molecular sieve; air;68%
25245-29-8

5-iodo-1,2,3-trimethoxybenzene

634-36-6

1,2,3-trimethoxybenzene

Conditions
ConditionsYield
With 2-(2-methoxyethoxy)ethyl alcohol; oxygen; sodium hydride In 1,4-dioxane at 20℃; for 24h; Schlenk technique; chemoselective reaction;95%
With hydrogen; triethylamine In methanol; water at 120℃; under 22502.3 Torr; for 52h; Autoclave;82%
1885-35-4

3,4,5-trimethoxybenzonitrile

634-36-6

1,2,3-trimethoxybenzene

Conditions
ConditionsYield
With lithium borohydride; C30H21F6N2NiO2P In tetrahydrofuran at 70℃; for 3h; Schlenk technique; Inert atmosphere;94%
87-66-1

2-hydroxyresorcinol

74-88-4

methyl iodide

634-36-6

1,2,3-trimethoxybenzene

Conditions
ConditionsYield
With potassium carbonate In acetone93%
for 6h;80%
With potassium hydroxide
With potassium carbonate In acetone
3840-31-1

(3,4,5-trimethoxyphenyl)methanol

634-36-6

1,2,3-trimethoxybenzene

Conditions
ConditionsYield
With chlorobis(cyclooctene)-iridium(I) dimer; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; lithium chloride In water; 1,3,5-trimethyl-benzene at 170℃; for 20h; Schlenk technique; Inert atmosphere;93%
With oxygen; palladium diacetate; sodium carbonate In cyclohexane at 130℃; for 48h; Molecular sieve; Schlenk technique;86%

1-(methylsulfonyl)-2-(3,4,5-trimethoxyphenyl)diazene

634-36-6

1,2,3-trimethoxybenzene

Conditions
ConditionsYield
In water; isopropyl alcohol for 14h; Irradiation;89%

1,2,3-Trimethoxybenzene Chemical Properties

Molecular Structure:

Molecular Formula: C9H12O3
Molecular Weight: 168.1898
IUPAC Name: 1,2,3-Trimethoxybenzene
Synonyms of 1,2,3-Trimethoxybenzene (CAS NO.634-36-6): AI3-02077 ; EINECS 211-207-2 ; Methylsyringol (VAN) ; NSC 10124 ; Pyrogallol trimethyl ether ; Tri-O-methylpyrogallol ; Benzene, 1,2,3-trimethoxy-
CAS NO: 634-36-6
Product Categories: Aromatic Hydrocarbons (substituted) & Derivatives ; Benzene derivates
Melting Point: 43-47 °C 
Index of Refraction: 1.485
Molar Refractivity: 46.28 cm3
Molar Volume: 161.4 cm3
Surface Tension: 29.8 dyne/cm
Density: 1.041 g/cm3
Flash Point: 70.4 °C
Enthalpy of Vaporization: 45.26 kJ/mol
Boiling Point: 235 °C at 760 mmHg
Vapour Pressure: 0.0784 mmHg at 25°C

 

1,2,3-Trimethoxybenzene Uses

 1,2,3-Trimethoxybenzene (CAS NO.634-36-6) is a pharmaceutical intermediate mainly used for synthesis of Trimetazidine.

1,2,3-Trimethoxybenzene Safety Profile

Safety Information of 1,2,3-Trimethoxybenzene (CAS NO.634-36-6):
Risk Statements:36/37/38
36/37/38:Irritating to eyes, respiratory system and skin  
Safety Statements:22-24/25
22:Do not breathe dust 
24/25:Avoid contact with skin and eyes 
WGK Germany:3
HS Code:29093090

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