Welcome to LookChem.com Sign In|Join Free
  • or
Home > Products >  > 

1-Acetamido-7-hydroxynaphthalene

Related Products

Hot Products

Name

1-Acetamido-7-hydroxynaphthalene

EINECS 229-293-5
CAS No. 6470-18-4 Density 1.297 g/cm3
PSA 49.33000 LogP 2.57680
Solubility N/A Melting Point 168-169 °C
Formula C12H11NO2 Boiling Point 486.2 °C at 760 mmHg
Molecular Weight 201.225 Flash Point 247.9 °C
Transport Information N/A Appearance N/A
Safety Risk Codes R36/37/38
Molecular Structure Molecular Structure of 6470-18-4 (1-Acetamido-7-hydroxynaphthalene) Hazard Symbols Xi
Synonyms

Acetamide,N-(7-hydroxy-1-naphthyl)- (6CI,8CI);1-Acetamido-7-naphthol;1-Acetylamino-7-naphthol;N-(7-Hydroxy-1-naphthyl)acetamide;N-(7-Hydroxynaphthalene-1-yl)-acetamide;NSC 7566;acetamide, N-(7-hydroxy-1-naphthalenyl)-;

Article Data 12

1-Acetamido-7-hydroxynaphthalene Synthetic route

29921-56-0

8-acetamidonaphthalen-2-yl acetate

6470-18-4

1-acetylamino-7-naphthol

Conditions
ConditionsYield
With sodium hydrogencarbonate In methanol for 1h; Reflux;96%
With sodium hydrogencarbonate In methanol
118-46-7

8-amino-2-naphthol

108-24-7

acetic anhydride

6470-18-4

1-acetylamino-7-naphthol

Conditions
ConditionsYield
In dichloromethane at 20℃; for 21h;88%
118-46-7

8-amino-2-naphthol

75-36-5

acetyl chloride

A

29921-56-0

8-acetamidonaphthalen-2-yl acetate

B

6470-18-4

1-acetylamino-7-naphthol

Conditions
ConditionsYield
With pyridine; benzene
118-46-7

8-amino-2-naphthol

6470-18-4

1-acetylamino-7-naphthol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: TEA / CHCl3
2: NaHCO3 (sat) / methanol
View Scheme
With acetic anhydride In methanol
In ice-water
119-28-8

8-amino-2-naphthalenesulfonic acid

6470-18-4

1-acetylamino-7-naphthol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydroxide; water / 250 - 260 °C
View Scheme
118-46-7

8-amino-2-naphthol

64-19-7

acetic acid

6470-18-4

1-acetylamino-7-naphthol

Conditions
ConditionsYield
With sodium hydroxide at 20 - 40℃; for 2h;120 g
6470-18-4

1-acetylamino-7-naphthol

74-88-4

methyl iodide

93189-18-5

N-(7-methoxynaphthalen-1-yl)acetamide

Conditions
ConditionsYield
With potassium carbonate In acetone for 1h; Reflux;90%
With potassium carbonate In acetone for 6h; Heating;
With potassium carbonate In acetone
18908-66-2

2-ethylhexyl bromide

6470-18-4

1-acetylamino-7-naphthol

C20H27NO2

Conditions
ConditionsYield
With potassium carbonate In acetonitrile for 9h; Reflux;88%
With potassium carbonate In acetonitrile for 9h; Reflux;88%
trifluoromethane anhydride

trifluoromethane anhydride

6470-18-4

1-acetylamino-7-naphthol

168901-50-6

2-trifluoromethanesulfonyloxy-8-acetylaminonaphthalene

Conditions
ConditionsYield
With dmap; trifluoromethanesulfonic acid anhydride In dichloromethane69.5%
141-43-5

ethanolamine

6470-18-4

1-acetylamino-7-naphthol

1627144-25-5

9-acetylamino-2-hydroxymethyl naphtho[2,1-d]oxazole

Conditions
ConditionsYield
With copper dichloride In acetonitrile at 60℃; for 15h;62%

1-Acetamido-7-hydroxynaphthalene Standards and Recommendations

Appearance: Gray powder
Content: 95% min
Purity: 97% min
Alkali insoluble matters: 0.1% max

1-Acetamido-7-hydroxynaphthalene Specification

The 1-Acetamido-7-hydroxynaphthalene, with the CAS registry number 6470-18-4 and EINECS registry number 229-293-5, has the systematic name of N-(7-hydroxynaphthalen-1-yl)acetamide. And the molecular formula of this chemical is C12H11NO2. It belongs to the product categories Intermediates of Dyes and Pigments. What's more, it should be used as intermediate of coupling component in neutral stain.

The physical properties of 1-Acetamido-7-hydroxynaphthalene are as following: (1)ACD/LogP: 1.58; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.58; (4)ACD/LogD (pH 7.4): 1.57; (5)ACD/BCF (pH 5.5): 9.3; (6)ACD/BCF (pH 7.4): 9.23; (7)ACD/KOC (pH 5.5): 171.7; (8)ACD/KOC (pH 7.4): 170.41; (9)#H bond acceptors: 3; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 29.54 Å2; (13)Index of Refraction: 1.704; (14)Molar Refractivity: 60.24 cm3; (15)Molar Volume: 155 cm3; (16)Polarizability: 23.88×10-24cm3; (17)Surface Tension: 59 dyne/cm; (18)Density: 1.297 g/cm3; (19)Flash Point: 247.9 °C; (20)Enthalpy of Vaporization: 78.05 kJ/mol; (21)Boiling Point: 486.2 °C at 760 mmHg; (22)Vapour Pressure: 4.45E-10 mmHg at 25°C.

Preparation of 1-Acetamido-7-hydroxynaphthalene: It can start with alkaline fusion of 1,7-cleve's acid, and gives the 8-amino-2-naphthol sodium salt. Then acidatewith dilute acid, and the 8-amino-2-naphthol will separate out. Acetylize it with acetic anhydride, and gives the desired product.

Preparation of 1-Acetamido-7-hydroxynaphthalene can start with alkaline fusion of 1,7-cleve's acid, and gives the 8-amino-2-naphthol sodium salt. Then acidatewith dilute acid, and the 8-amino-2-naphthol will separate out. Acetylize it with acetic anhydride, and gives the desired product

You can still convert the following datas into molecular structure:
(1)SMILES: O=C(Nc1c2c(ccc1)ccc(O)c2)C
(2)InChI: InChI=1/C12H11NO2/c1-8(14)13-12-4-2-3-9-5-6-10(15)7-11(9)12/h2-7,15H,1H3,(H,13,14)
(3)InChIKey: ALNWQAFPXMGLTJ-UHFFFAOYAR

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 6470-18-4