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Cas Database |
| Name |
2'-O-Methyluridine |
EINECS | 2017-001-1 |
| CAS No. | 2140-76-3 | Density | 1.536 g/cm3 |
| PSA | 113.78000 | LogP | -2.19780 |
| Solubility | N/A | Melting Point |
154-156 ºC |
| Formula | C10H14N2O6 | Boiling Point | N/A |
| Molecular Weight | 258.231 | Flash Point | N/A |
| Transport Information | N/A | Appearance | White solid |
| Safety | 24/25 | Risk Codes | 26/27/28 |
| Molecular Structure |
|
Hazard Symbols |
 T+
|
| Synonyms |
O(2)-Methyluridine;Uridine, 2-O-methyl-;1-[(2R,3R,4R,5R)-4-Hydroxy-5-(hydroxymethyl)-3-methoxy-oxolan-2-yl]pyrimidine-2,4-dione; |
Article Data | 37 |
2'-O-Methyluridine Synthetic route
- 156541-83-2
1'-(3',5'-O-benzyl-2'-O-methyl-β-D-ribofuranosyl)uracil
- 2140-76-3
2'-O-methyluridine
| Conditions | Yield |
|---|---|
| With hydrogen; palladium on activated charcoal In ethyl acetate at 25℃; under 760 Torr; for 0.5h; | 99% |
- 83167-64-0
3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disilyl)-2'-O-methyluridine
- 2140-76-3
2'-O-methyluridine
| Conditions | Yield |
|---|---|
| With tetrabutyl ammonium fluoride In tetrahydrofuran at 20℃; for 2h; | 95% |
| With potassium fluoride; tetraethylammonium bromide In methanol; water | 78% |
| With potassium fluoride; tetraethylammonium chloride In water; acetonitrile at 53℃; for 0.5h; | 69 % Spectr. |
| With tetrabutyl ammonium fluoride In tetrahydrofuran |
- 1384271-34-4
C25H28N2O7
- 2140-76-3
2'-O-methyluridine
| Conditions | Yield |
|---|---|
| With formic acid; palladium on activated charcoal; hydrogen In water; isopropyl alcohol under 760.051 Torr; for 12h; | 95% |
- 98917-55-6
3',5'-O-1,1,3,3-tetraisopropyldisiloxyl-2'-O-methyl-3-N-(2,4-dinitrobenzene)sulfenyluridine
- 2140-76-3
2'-O-methyluridine
| Conditions | Yield |
|---|---|
| With tetrabutyl ammonium fluoride In tetrahydrofuran at 20℃; for 0.0333333h; | 92% |
| Conditions | Yield |
|---|---|
| With Trimethyl borate; sodium carbonate In methanol at 140 - 150℃; Ring cleavage; | 92% |
- 2414-98-4
magnesium ethylate
- 292037-79-7
O2,2'-anhydro-1-(β-D-arabinofuranosyl)uracil
- 2140-76-3
2'-O-methyluridine
| Conditions | Yield |
|---|---|
| In methanol for 5h; Reflux; Large scale; | 92% |
- 3736-77-4
2,2'-Anhydrouridine
- 109-88-6, 16436-83-2, 16436-85-4
magnesium methanolate
- 2140-76-3
2'-O-methyluridine
| Conditions | Yield |
|---|---|
| In methanol for 5h; Heating; | 88% |
- 79816-14-1
3',5'-di-O-benzoyl-2'-O-methyluridine
- 2140-76-3
2'-O-methyluridine
| Conditions | Yield |
|---|---|
| With ammonium hydroxide In methanol Ambient temperature; | 86% |
- 121-43-7
Trimethyl borate
- 847650-91-3
1-((2R,4S,5R)-3,4-anhydro-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-4(1H)-one
- 2140-76-3
2'-O-methyluridine
| Conditions | Yield |
|---|---|
| With sodium hydrogencarbonate; trimethyl orthoformate In methanol at 150℃; under 10343 Torr; for 42h; | 86% |
- 138935-28-1
2'-O-methyl-5'-O-(monomethoxytrityl)uridine
- 2140-76-3
2'-O-methyluridine
| Conditions | Yield |
|---|---|
| With acetic acid Ambient temperature; | 85% |
2'-O-Methyluridine Standards and Recommendations
Assay(HPLC): ≥99%
2'-O-Methyluridine Specification
The 2'-O-Methyluridine, with the CAS registry number 2140-76-3, is also known as Uridine, 2'-O-methyl-. It belongs to the product categories of Bases & Related Reagents; Carbohydrates & Derivatives; Heterocycles; Nucleotides. This chemical's molecular formula is C10H14N2O6 and molecular weight is 258.23. What's more, its systematic name is the same with its product name. It should be stored at 0 °C. This chemical can be used for preparation of antiviral nucleoside derivatives as inhibitors of subgenomic hepatitis C virus RNA replication.
Physical properties about 2'-O-Methyluridine are: (1)ACD/LogP: -0.823; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -0.82; (4)ACD/LogD (pH 7.4): -0.83; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 8.50; (8)ACD/KOC (pH 7.4): 8.41; (9)#H bond acceptors: 8; (10)#H bond donors: 3; (11)#Freely Rotating Bonds: 5; (12)Polar Surface Area: 108.33 Å2; (13)Index of Refraction: 1.611; (14)Molar Refractivity: 58.4 cm3; (15)Molar Volume: 168.194 cm3; (16)Polarizability: 23.152×10-24cm3; (17)Surface Tension: 72.374 dyne/cm; (18)Density: 1.535 g/cm3.
When you are dealing with this chemical, you should be very careful. This chemical is very toxic by inhalation, in contact with skin and if swallowed. It may cause damage to health at very low levels. Therefore, you should avoid contacting with skin and eyes.
You can still convert the following datas into molecular structure:
(1) SMILES: O=C/1NC(=O)N(\C=C\1)[C@@H]2O[C@@H]([C@@H](O)[C@H]2OC)CO
(2) InChI: InChI=1S/C10H14N2O6/c1-17-8-7(15)5(4-13)18-9(8)12-3-2-6(14)11-10(12)16/h2-3,5,7-9,13,15H,4H2,1H3,(H,11,14,16)/t5-,7-,8-,9-/m1/s1
(3) InChIKey: SXUXMRMBWZCMEN-ZOQUXTDFSA-N
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