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Cas Database |
| Name |
2,3,5-Collidine |
EINECS | 211-786-1 |
| CAS No. | 695-98-7 | Density | 0.921 g/cm3 |
| PSA | 12.89000 | LogP | 2.00680 |
| Solubility | slightly soluble in water | Melting Point |
-56.98°C (estimate) |
| Formula | C8H11N | Boiling Point | 187.3 °C at 760 mmHg |
| Molecular Weight | 121.182 | Flash Point | 42.8 °C |
| Transport Information | N/A | Appearance | clear colourless to very slightly yellow liquid |
| Safety | 26-36-36/37 | Risk Codes | 36/37/38-20/21/22 |
| Molecular Structure |
|
Hazard Symbols |
 Xn,  Xi,  T
|
| Synonyms |
2,3,5-Trimethylpyridine; |
Article Data | 17 |
2,3,5-Collidine Synthetic route
- 695-98-7
2,3,5-trimethyl-pyridine
Conditions
| Conditions | Yield |
|---|---|
| With potassium tert-butylate In tetrahydrofuran for 1h; Reflux; | 91% |
Conditions
| Conditions | Yield |
|---|---|
| With Raney nickel at 180℃; for 0.5h; Concentration; Flow reactor; Green chemistry; regioselective reaction; | 90% |
- 109371-17-7
2,4-dichloro-3,5,6-trimethylpyridine
- 695-98-7
2,3,5-trimethyl-pyridine
Conditions
| Conditions | Yield |
|---|---|
| With ammonium hydroxide; hydrogen; palladium on activated charcoal In ethanol under 2250.2 Torr; for 3h; further reagent zinc powder, H2SO4; | 83% |
- 109371-17-7
2,4-dichloro-3,5,6-trimethylpyridine
A
- 695-98-7
2,3,5-trimethyl-pyridine
B
- 109371-18-8
4-chloro-2,3,5-trimethylpyridine
C
- 121767-77-9
2-chloro-3,5,6-trimethylpyridine
Conditions
| Conditions | Yield |
|---|---|
| With sulfuric acid; hydrogen; palladium on activated charcoal In ethanol at 20℃; under 1500.1 Torr; | A n/a B 78% C n/a |
Conditions
| Conditions | Yield |
|---|---|
| With potassium hexafluorophosphate; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; copper diacetate In tert-Amyl alcohol at 100℃; for 24h; Inert atmosphere; Schlenk technique; regioselective reaction; | 45% |
Conditions
| Conditions | Yield |
|---|---|
| With diethyl ether; toluene |
- 856851-26-8
3-chloromethyl-2,5-dimethyl-pyridine
- 695-98-7
2,3,5-trimethyl-pyridine
Conditions
| Conditions | Yield |
|---|---|
| With methanol; palladium on activated charcoal Hydrogenation; |
- 22739-24-8
N-methyl-3,5-dimethylpyridinium iodide
A
- 695-98-7
2,3,5-trimethyl-pyridine
B
- 3748-84-3
2,3,5,6-tetramethylpyridine
Conditions
| Conditions | Yield |
|---|---|
| at 300 - 320℃; im Rohr; | |
| at 300 - 320℃; im Rohr; |
Conditions
| Conditions | Yield |
|---|---|
| With aluminum oxide; ammonia at 330 - 340℃; |
Conditions
| Conditions | Yield |
|---|---|
| With piperidine hydrochloride In toluene at 200℃; for 2h; autoclave; | 6 % Chromat. |
2,3,5-Collidine Chemical Properties
MF: C8H11N 
MW: 121.18
bp of 2,3,5-Trimethyl Pyridine (695-98-7): 184 °C(lit.)
density of 2,3,5-Trimethyl Pyridine (695-98-7): 0.931 g/mL at 25 °C(lit.)
refractive index: n20/D 1.508(lit.)
Fp of 2,3,5-Trimethyl Pyridine (695-98-7): 165 °F
Water Solubility: SLIGHTLY SOLUBLE
PHYSICAL STATE: clear to light yellow liquid
MW: 121.18
bp of 2,3,5-Trimethyl Pyridine (695-98-7): 184 °C(lit.)
density of 2,3,5-Trimethyl Pyridine (695-98-7): 0.931 g/mL at 25 °C(lit.)
refractive index: n20/D 1.508(lit.)
Fp of 2,3,5-Trimethyl Pyridine (695-98-7): 165 °F
Water Solubility: SLIGHTLY SOLUBLE
PHYSICAL STATE: clear to light yellow liquid
2,3,5-Collidine Uses
2,3,5-Trimethyl Pyridine (695-98-7) is used as an intermediate for the synthesis of pharmaceuticals especially for drugs of the proton pump inhibitors to block the production of stomach acid (such as omeprazole). It is also used as a good solvent.
2,3,5-Collidine Toxicity Data With Reference
Harmful by inhalation and in contact with skin.
Acute Toxicity: LD50 : Not available
Acute Toxicity: LD50 : Not available
2,3,5-Collidine Safety Profile
Hazard Codes: Xi,T,Xn (Irritant; Toxic; Harmful)
Risk Statements: 36/37/38-20/21/22 (Irritating to eyes, respiratory system and skin; Harmful by inhalation, in contact with skin and if swallowed)
Safety Statements: 26-36-36/37 (In case of contact with eyes, rinse immediately with plenty of water and seek medical advice; Wear suitable protective clothing; Wear suitable protective clothing and gloves)
WGK Germany: 3
Hazard Note: Toxic
Risk Statements: 36/37/38-20/21/22 (Irritating to eyes, respiratory system and skin; Harmful by inhalation, in contact with skin and if swallowed)
Safety Statements: 26-36-36/37 (In case of contact with eyes, rinse immediately with plenty of water and seek medical advice; Wear suitable protective clothing; Wear suitable protective clothing and gloves)
WGK Germany: 3
Hazard Note: Toxic
2,3,5-Collidine Standards and Recommendations
ASSAY: 99.0% min
LOSS ON DRYING: 0.5% max
MOISTURE: 0.5% max
LOSS ON DRYING: 0.5% max
MOISTURE: 0.5% max
2,3,5-Collidine Specification
Storage of 2,3,5-Trimethyl Pyridine (695-98-7): Protect from moisture. Store in tightly sealed containers in a cool place.
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2,3,5-Collidine
