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2,4-Difluorobenzylamine
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Name

2,4-Difluorobenzylamine

 EINECS 276-502-0
CAS No. 72235-52-0 Density 1.214 g/cm3
PSA 26.02000 LogP 2.12380
Solubility N/A Melting Point 255-256 °C(Solv: N,N-dimethylformamide (68-12-2))
Formula C7H7F2N Boiling Point 177.8 °C at 760 mmHg
Molecular Weight 143.136 Flash Point 68.3 °C
Transport Information UN 2735 8/PG 3 Appearance clear colorless to light yellow liquid
Safety 26-27-36/37/39-45-25 Risk Codes 34
Molecular Structure Molecular Structure of 72235-52-0 (2,4-Difluorobenzylamine) Hazard Symbols CorrosiveC
Synonyms

(2,4-Difluorophenyl)methanamine;2,4-Difluorobenzenemethanamine;[(2,4-Difluorophenyl)methyl]amine;

Article Data 7

2,4-Difluorobenzylamine Synthetic route

C13H17F2N4(1+)*Br(1-)

72235-52-0

2,4-Difluoro-benzylamine

Conditions
ConditionsYield
With hydrogenchloride In methanol; water for 6h; Reflux;90.8%
3939-09-1

2,4-difluorobenzonitrile

72235-52-0

2,4-Difluoro-benzylamine

Conditions
ConditionsYield
With ammonium hydroxide; hydrogen In water; isopropyl alcohol at 60 - 80℃; under 7500.75 Torr; Temperature; Reagent/catalyst;90%
With [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; 1,4-di(diphenylphosphino)-butane; iso-butanol; sodium hydroxide at 120℃; for 0.333333h; Inert atmosphere;75 %Chromat.
372-18-9

1,3-Difluorobenzene

72235-52-0

2,4-Difluoro-benzylamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrogen bromide; iron(III) chloride / 1,4-dioxane / 7 h / Reflux
2: 1,4-dioxane / 4 h / Reflux
3: hydrogenchloride / water; methanol / 6 h / Reflux
View Scheme
Multi-step reaction with 3 steps
1: hydrogenchloride; zinc(II) chloride / acetonitrile; water / 8 h / Reflux
2: toluene / 2 h / Reflux; Industrial scale
3: hydrogenchloride / water; isopropyl alcohol / 5 h / Reflux
View Scheme
Multi-step reaction with 4 steps
1.1: nitrobenzene / 2 h / 70 - 105 °C
2.1: ozone / chlorobenzene / 1.5 h / 0 °C
3.1: thionyl chloride / dichloromethane / 1 h / 50 °C
3.2: 1.5 h / 50 °C
4.1: sodium chloride; bromine / 2 h / 50 °C
View Scheme
452-07-3

2,4-difluorobenzyl chloride

72235-52-0

2,4-Difluoro-benzylamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: toluene / 2 h / Reflux; Industrial scale
2: hydrogenchloride / water; isopropyl alcohol / 5 h / Reflux
View Scheme

(2,4-difluoro-benzyl)-hexamethylenetetraminium; chloride

72235-52-0

2,4-Difluoro-benzylamine

Conditions
ConditionsYield
With hydrogenchloride In water; isopropyl alcohol for 5h; Reflux;
937397-44-9

{1-benzyl-3-[(3-fluoro-4-nitro-benzenesulfonyl)-isobutyl-amino]-2-hydroxy-propyl}-carbamic acid hexahydro-furo[2,3-b]furan-3-yl ester

72235-52-0

2,4-Difluoro-benzylamine

937721-16-9

(1-benzyl-3-{[3-(2,4-difluoro-benzylamino)-4-nitro-benzenesulfonyl]-isobutyl-amino}-2-hydroxy-propyl)-carbamic acid hexahydro-furo[2,3-b]furan-3-yl ester

Conditions
ConditionsYield
In tetrahydrofuran for 18h; Heating / reflux;100%
72235-52-0

2,4-Difluoro-benzylamine

75-36-5

acetyl chloride

1030596-28-1

C9H9F2NO

Conditions
ConditionsYield
With triethylamine at 20℃;100%
72235-52-0

2,4-Difluoro-benzylamine

556-61-6

methyl thioisocyanate

1400799-52-1

1-(2,4-difluorobenzyl)-3-methylthiourea

Conditions
ConditionsYield
at 20℃;99%
1357289-08-7

2,5-dimethyl 3-(benzyloxy)-1-(2,2-dimethoxyethyl)-4-oxo-1,4-dihydropyridine-2,5-dicarboxylate

72235-52-0

2,4-Difluoro-benzylamine

1229006-21-6

1-[2,2-bis(methyloxy)ethyl]-5-({[(2,4-difluorophenyl)methyl]amino}carbonyl)-4-oxo-3-[(phenylmethyl)oxy]-1,4-dihydro-2-pyridinecarboxylic acid methyl ester

Conditions
ConditionsYield
With acetic acid In toluene at 90℃; for 7h; Reagent/catalyst;97%
With acetic acid In toluene at 90 - 95℃; Solvent; regioselective reaction;210 g

5-(((tert-butoxycarbonyl)amino)methyl)-2-(3-(cyclopropylmethoxy)-4-methoxyphenyl)oxazole-4-carboxylic acid

72235-52-0

2,4-Difluoro-benzylamine

tert-butyl ((2-(3-(cyclopropylmethoxy)-4-methoxyphenyl)-4-((2,4-difluorobenzyl)carbamoyl)oxazol-5-yl)methyl)carbamate

Conditions
ConditionsYield
Stage #1: 5-(((tert-butoxycarbonyl)amino)methyl)-2-(3-(cyclopropylmethoxy)-4-methoxyphenyl)oxazole-4-carboxylic acid With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0℃; for 0.5h;
Stage #2: 2,4-Difluoro-benzylamine With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 12h;		97%

2,4-Difluorobenzylamine Chemical Properties

Chemistry informtion about 2,4-Difluorobenzylamine (CAS NO.72235-52-0) is:
IUPAC Name: (2,4-Difluorophenyl)Methanamine
Synonyms: 2,4-Difluorobenzylamine ; Rarechem Al Bw 0282 ; 2,4-Difluorobenzylamine 97% ; 2,4-Difluorobenzylamine97% ; 2,4-Difluorobenzylamine Hydrochloride ; 2,4-Difluorobenzylamine, 98+% ; (2,4-Difluorophenyl)Methanamine ; Benzenemethanamine, 2,4-Difluoro-
MF: C7H7F2N
MW: 143.13
EINECS: 276-502-0 
Density: 1.214 g/cm3
Flash Point: 79.4 °C
Boiling Point: 183.8 °C at 760 mmHg
Vapour Pressure: 0.756 mmHg at 25°C 
Enthalpy of Vaporization: 42.01 kJ/mol
Refractive Index: n20/D 1.49(lit.)
Sensitive: Air Sensitive
BRN: 3539259
Following is the molecular structure of 2,4-Difluorobenzylamine (CAS NO.72235-52-0) is:

2,4-Difluorobenzylamine Safety Profile

Safty information about 2,4-Difluorobenzylamine (CAS NO.72235-52-0) :
Hazard Codes:
C: Corrosive
Risk Statements:
R34:Causes burns.
Safety Statements:
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.  
S27:Take off immediately all contaminated clothing. 
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) 
S25:Avoid contact with eyes.
RIDADR: UN 2735 8/PG 3
WGK Germany: 3
Hazard Note: Corrosive
HazardClass: 8
PackingGroup: III

2,4-Difluorobenzylamine Specification

2,4-Difluorobenzylamine (CAS NO.72235-52-0) is a clear colorless to light yellow liquid.
First Aid Measures:
Ingestion: Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation: Get medical aid immediately. Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen. Do not use mouth-to-mouth respiration. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
Skin: Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Destroy contaminated shoes.
Eyes: Get medical aid immediately. Do not allow victim to rub or keep eyes closed. Extensive irrigation is required (at least 30 minutes).
Handling and Storage:
Storage: Keep away from heat, sparks, and flame. Keep away from sources of ignition. Keep container closed when not in use. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Corrosives area.
Handling: Wash thoroughly after handling. Use only in a well ventilated area. Do not get in eyes, on skin, or on clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid contact with heat, sparks and flame. Do not ingest or inhale. Use only in a chemical fume hood. Discard contaminated shoes. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.

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