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Name	2-Amino-3-(trifluoromethyl)pyridine	EINECS	N/A
CAS No.	183610-70-0	Density	1.368 g/cm³
PSA	38.91000	LogP	2.26380
Solubility	N/A	Melting Point	70-72 °C
Formula	C₆H₅F₃N₂	Boiling Point	203.2 °C at 760 mmHg
Molecular Weight	162.114	Flash Point	76.7 °C
Transport Information	N/A	Appearance	N/A
Safety	26-36/37/39	Risk Codes	Xi:Irritant;
Molecular Structure		Hazard Symbols	Xi
Synonyms	(3-Trifluoromethylpyridin-2-yl)amine;3-(Trifluoromethyl)-2-pyridinamine;	Article Data	7

2-Amino-3-(trifluoromethyl)pyridine Synthetic route

: 65753-52-8
2-fluoro-3-trifluoromethylpyridine

: 183610-70-0
2-amino-3-trifluoromethylpyridine

Conditions

Conditions	Yield
With ammonia In water at 130℃; under 22502.3 Torr; for 10h; Temperature;	95%

: 911112-72-6
(4-methoxy-benzyl)-(3-trifluoromethyl-pyridin-2-yl)-amine

: 183610-70-0
2-amino-3-trifluoromethylpyridine

Conditions

Conditions	Yield
Stage #1: (4-methoxy-benzyl)-(3-trifluoromethyl-pyridin-2-yl)-amine With sulfuric acid at 5 - 23℃; for 0.5h; Stage #2: With sodium hydroxide In water at 0℃;	92%

: 65753-47-1
2-chloro-3-trifluoromethyl-pyridine

: 183610-70-0
2-amino-3-trifluoromethylpyridine

Conditions

Conditions	Yield
With ammonia In water at 175℃; for 24h;	71%
With ammonia In water at 175℃; for 72h;
Multi-step reaction with 2 steps 1: hydrogen fluoride / 48 h / 130 °C / 60006 Torr / Autoclave 2: ammonia / water / 10 h / 130 °C / 22502.3 Torr View Scheme

: 67-56-1
methanol

: 143812-76-4
8-Trifluoromethyl-tetrazolo[1,5-a]pyridine

A: 183610-70-0
2-amino-3-trifluoromethylpyridine

B: 177211-80-2
2-methoxy-4-trifluoromethyl-1H-1,3-diazepine

Conditions

Conditions	Yield
In 1,4-dioxane at 25℃; for 1.33333h; Irradiation;	A 5% B 47%

: 183610-70-0
2-amino-3-trifluoromethylpyridine

: 79456-34-1
5-bromo-3-(trifluoromethyl)pyridin-2-amine

Conditions

Conditions	Yield
With N-Bromosuccinimide In acetonitrile at 0 - 20℃;	99%
With N-Bromosuccinimide In acetonitrile at 5 - 23℃; for 1h;	98%
With N-Bromosuccinimide In acetonitrile at 20℃;	93%

: 183610-70-0
2-amino-3-trifluoromethylpyridine

: 5-iodo-3-(trifluoromethyl)pyridin-2-amine

Conditions

Conditions	Yield
With N-iodo-succinimide; acetic acid at 0 - 20℃; for 90h;	89%
Stage #1: 2-amino-3-trifluoromethylpyridine With N-iodo-succinimide; acetic acid at 0 - 20℃; Stage #2: With sodium hydrogencarbonate In water Cooling with ice;	76%
With N-iodo-succinimide	76%
With N-iodo-succinimide In acetic acid at 0 - 20℃;	76%
With N-iodo-succinimide In N,N-dimethyl-formamide at 20℃;	70%

: 183610-70-0
2-amino-3-trifluoromethylpyridine

: 79456-33-0
5-chloro-3-(trifluoromethyl)pyridin-2-amine

Conditions

Conditions	Yield
With N-chloro-succinimide In N,N-dimethyl-formamide at 60℃; for 1h;	88%
With N-chloro-succinimide In N,N-dimethyl-formamide at 60℃; for 1h;	88%
With N-chloro-succinimide In N,N-dimethyl-formamide at 60℃; for 1h; Inert atmosphere;

: 108-94-1
cyclohexanone

: 183610-70-0
2-amino-3-trifluoromethylpyridine

: 4-(trifluoromethyl)benzo[4,5]imidazo[1,2-a]pyridine

Conditions

Conditions	Yield
With iodine; oxygen In 1,1,2,2-tetrachloroethane at 160℃; for 24h; Green chemistry;	88%

: 183610-70-0
2-amino-3-trifluoromethylpyridine

: C6H5F3N2O

Conditions

Conditions	Yield
With 3-chloro-benzenecarboperoxoic acid In acetone at 0 - 20℃; for 12.5h;	81%

: 183610-70-0
2-amino-3-trifluoromethylpyridine

: 1121056-94-7
5-nitro-3-(trifluoromethyl)pyridin-2-amine

Conditions

Conditions	Yield
With sulfuric acid; nitric acid In water at 0 - 50℃; for 3.25h;	75%

2-Amino-3-(trifluoromethyl)pyridine Specification

The 2-Amino-3-(trifluoromethyl)pyridine is an organic compound with the formula C₆H₅F₃N₂. The systematic name of this chemical is 3-(trifluoromethyl)pyridin-2-amine. With the CAS registry number 183610-70-0, it is also named as 2-Pyridinamine, 3-(trifluoromethyl)-. The product's categories are Amines and Anilines; Heterocycles; Pyridines, Pyrimidines, Purines and Pteredines; Amines; Pyridines. Additionally, this chemical should be stored at room temperature.

The other characteristics of 2-Amino-3-(trifluoromethyl)pyridine can be summarized as: (1)ACD/LogP: 2.09; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 2.07; (4)ACD/LogD (pH 7.4): 2.09; (5)ACD/BCF (pH 5.5): 21.82; (6)ACD/BCF (pH 7.4): 22.84; (7)ACD/KOC (pH 5.5): 312.05; (8)ACD/KOC (pH 7.4): 326.63; (9)#H bond acceptors: 2; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 0; (12)Polar Surface Area: 16.13 Å²; (13)Index of Refraction: 1.478; (14)Molar Refractivity: 33.56 cm³; (15)Molar Volume: 118.4 cm³; (16)Polarizability: 13.3×10^-24 cm³; (17)Surface Tension: 33.2 dyne/cm; (18)Density: 1.368 g/cm³; (19)Flash Point: 76.7 °C; (20)Enthalpy of Vaporization: 43.95 kJ/mol; (21)Boiling Point: 203.2 °C at 760 mmHg; (22)Vapour Pressure: 0.28 mmHg at 25°C

People can use the following data to convert to the molecule structure.
1. SMILES:FC(F)(F)c1cccnc1N
2. InChI:InChI=1/C6H5F3N2/c7-6(8,9)4-2-1-3-11-5(4)10/h1-3H,(H2,10,11)
3. InChIKey:YWOWJQMFMXHLQD-UHFFFAOYAV
4. Std. InChI:InChI=1S/C6H5F3N2/c7-6(8,9)4-2-1-3-11-5(4)10/h1-3H,(H2,10,11)
5. Std. InChIKey:YWOWJQMFMXHLQD-UHFFFAOYSA-N

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