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Cas Database |
| Name |
2-Amino-3-pyridinecarboxaldehyde |
EINECS | -0 |
| CAS No. | 7521-41-7 | Density | 1.264 g/cm3 |
| PSA | 55.98000 | LogP | 1.05750 |
| Solubility | insoluble in water | Melting Point |
98-102 °C(lit.) |
| Formula | C6H6N2O | Boiling Point | 290.7 °C at 760 mmHg |
| Molecular Weight | 122.126 | Flash Point | 129.6 °C |
| Transport Information | N/A | Appearance | yellow crystals |
| Safety | 26-36-36/37/39 | Risk Codes | 36/37/38-20/21/22 |
| Molecular Structure |
|
Hazard Symbols |
 Xn,  Xi
|
| Synonyms |
Nicotinaldehyde,2-amino- (6CI,7CI,8CI);2-Amino-3-formylpyridine;2-Aminonicotinaldehyde;2-Aminopyridine-3-carboxyaldehyde;2-Aminopyridine-3-carbaldehyde; |
Article Data | 36 |
2-Amino-3-pyridinecarboxaldehyde Synthetic route
- 86847-64-5
N-(3-formyl-2-pyridinyl)-2,2-dimethylpropanamide
- 7521-41-7
2-Aminonicotinaldehyde
| Conditions | Yield |
|---|---|
| Stage #1: N-(3-formyl-2-pyridinyl)-2,2-dimethylpropanamide With hydrogenchloride In water for 18h; Heating / reflux; Stage #2: With potassium carbonate In water at 20℃; pH=7; | 100% |
| With hydrogenchloride for 4h; Heating; | 93% |
| With hydrogenchloride In water |
- 86847-59-8
2-(pivaloylamino)pyridine
- 68-12-2, 33513-42-7
N,N-dimethyl-formamide
- 7521-41-7
2-Aminonicotinaldehyde
| Conditions | Yield |
|---|---|
| Multistep reaction; | 84% |
- 23612-57-9
(2-amino-3-pyridinyl)methanol
- 7521-41-7
2-Aminonicotinaldehyde
| Conditions | Yield |
|---|---|
| With manganese(IV) oxide In dichloromethane at 20℃; | 83% |
| With manganese(IV) oxide In dichloromethane at 20℃; | 83% |
| With manganese(IV) oxide In dichloromethane at 20℃; for 18h; |
- 114858-36-5
2-<3-(dibromomethyl)-2-pyridinyl>-1H-isoindole-1,3(2H)-dione
- 7521-41-7
2-Aminonicotinaldehyde
| Conditions | Yield |
|---|---|
| Stage #1: 2-<3-(dibromomethyl)-2-pyridinyl>-1H-isoindole-1,3(2H)-dione With ammonia In ethanol; water at 4 - 20℃; for 1.16667h; Stage #2: With hydrogenchloride In water for 3h; Heating / reflux; | 70% |
| Multi-step reaction with 2 steps 1: NH4OH / ethanol 2: 65 percent / HCl(conc) / 3 h / Heating View Scheme |
- 114858-37-6
2-(3-Iminomethyl-pyridin-2-yl)-isoindole-1,3-dione
- 7521-41-7
2-Aminonicotinaldehyde
| Conditions | Yield |
|---|---|
| With hydrogenchloride for 3h; Heating; | 65% |
- 855313-30-3
2-tert-butylamino-pyridine-3-carbaldehyde
- 7521-41-7
2-Aminonicotinaldehyde
| Conditions | Yield |
|---|---|
| With hydrogenchloride | 52% |
- 1004-16-6
3-cyano-1-methylpyridinium iodide
A
- 100-54-9
pyridine-3-carbonitrile
B
- 7521-41-7
2-Aminonicotinaldehyde
C
- 32399-08-9
2-methylamino-3-pyridinecarboxaldehyde
| Conditions | Yield |
|---|---|
| With ammonium hydroxide at 180℃; for 35h; | A 45% B 6% C 8% |
- 116026-94-9
2--3-pyridinecarboxaldehyde
- 7521-41-7
2-Aminonicotinaldehyde
| Conditions | Yield |
|---|---|
| With trifluoroacetic acid In dichloromethane at 20℃; Inert atmosphere; | 40% |
| Conditions | Yield |
|---|---|
| With hydrogenchloride In water for 1h; | 38% |
| With hydrogenchloride at 100℃; | 38% |
| With hydrogenchloride In water for 4h; Reflux; Inert atmosphere; | 30% |
| Conditions | Yield |
|---|---|
| Stage #1: nicotinamide With ammonium sulfamate at 150 - 200℃; for 9h; Stage #2: With ammonia In water for 1h; Stage #3: With hydrogenchloride for 4h; Heating; | 11% |
| Multi-step reaction with 2 steps 1: ammonium sulfamate / 11 h / 150 - 200 °C 2: 2 N HCl, water / 4 h / Heating View Scheme | |
| Stage #1: nicotinamide With hydrogenchloride; ammonium sulphamate In water Stage #2: With sodium hydroxide |
2-Amino-3-pyridinecarboxaldehyde Chemical Properties
Molecular Formula: C6H6N2O
Molecular Weight: 122.12
Index of Refraction: 1.652
Molar Refractivity: 35.33 cm3
Molar Volume: 96.6 cm3
Surface Tension: 63.1 dyne/cm
Density: 1.264 g/cm3
Flash Point: 129.6 °C
Enthalpy of Vaporization: 53.01 kJ/mol
Boiling Point: 290.7 °C at 760 mmHg
Vapour Pressure: 0.00204 mmHg at 25 °C
Melting point: 98-102 °C(lit.)
Storage tempreture: Refrigerator (+4 °C)
Water solubility: Insoluble
Sensitive: Air sensitive
Appearance: Yellow crystals
Structure of 2-Amino-3-formylpyridine (CAS NO.7521-41-7):
IUPAC Name: 2-Aminopyridine-3-carbaldehyde
Canonical SMILES: C1=CC(=C(N=C1)N)C=O
InChI: InChI=1S/C6H6N2O/c7-6-5(4-9)2-1-3-8-6/h1-4H,(H2,7,8)
InChIKey: NXMFJCRMSDRXLD-UHFFFAOYSA-N
Product Category of 2-Amino-3-formylpyridine (CAS NO.7521-41-7): pharmacetical;Pyridine series;Pyridines;Heterocyclic Building Blocks
2-Amino-3-pyridinecarboxaldehyde Toxicity Data With Reference
1、RTECS#: CAS# 7521-41-7: None listed
2、LD50/LC50: RTECS: Not available.
3、Carcinogenicity: 2-Amino-3-pyridinecarboxaldehyde - Not listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65.
4、Other: The toxicological properties have not been fully investigated.
2-Amino-3-pyridinecarboxaldehyde Consensus Reports
2-Amino-3-formylpyridine is reported in EPA TSCA Inventory.
2-Amino-3-pyridinecarboxaldehyde Safety Profile
Hazard Codes of 2-Amino-3-formylpyridine (CAS NO.7521-41-7): 
Xi,
Xn
Risk Statements: 36/37/38-20/21/22
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36-36/37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
2-Amino-3-pyridinecarboxaldehyde Specification
2-Amino-3-formylpyridine , its cas register number is 7521-41-7. It also can be called 2-Aminonicotinaldehyde ; and 2-Amino-3-pyridinecarboxaldehyde . It is hazardous, so the first aid measures and others should be known. Such as: When on the skin: first, should flush skin with plenty of water immediately for at least 15 minutes while removing contaminated clothing. Secondly, get medical aid. Or in the eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Then get medical aid soon. While, it's inhaled: Remove from exposure and move to fresh air immediately. Give artificial respiration while not breathing. When breathing is difficult, give oxygen. And as soon as to get medical aid. Then you have the ingesting of the product: Wash mouth out with water, and get medical aid immediately.
In addition, 2-Amino-3-formylpyridine (CAS NO.7521-41-7) should be exposured to air. It is not compatible with strong oxidizing agents, and you must not take it with incompatible materials. And also prevent it to broken down into hazardous decomposition products: Nitrogen oxides, carbon monoxide, carbon dioxide.
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