2-Amino-5-bromo-3-methylpyridine supplier

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Cas Database

Name	2-Amino-5-bromo-3-methylpyridine	EINECS	-0
CAS No.	3430-21-5	Density	1.593 g/cm³
PSA	38.91000	LogP	2.31590
Solubility	N/A	Melting Point	88-95 °C(lit.)
Formula	C₆H₇BrN₂	Boiling Point	250 °C at 760 mmHg
Molecular Weight	187.039	Flash Point	105 °C
Transport Information	N/A	Appearance	Yellow Solid
Safety	26-36	Risk Codes	36/37/38
Molecular Structure		Hazard Symbols	Xi
Synonyms	5-bromo-3-methyl-pyridin-2-amine;5-bromo-3-methyl-1H-pyridin-2-amine;2-Amino-5-Bromo-3-picoline;2-Amina-5-bromo-3-picoline;5-bromo-3-methylpyridin-2-amine;2-amino-3-methyl-5-bromopyridine;5-Bromo-3-methyl-pyridin-2-ylamine;	Article Data	17

2-Amino-5-bromo-3-methylpyridine Synthetic route

: 1603-40-3
3-methylpyridin-2-ylamine

: 3430-21-5
5-bromo-3-methyl-pyridin-2-ylamine

Conditions

Conditions	Yield
Stage #1: 3-methylpyridin-2-ylamine With bromine In dichloromethane at 0 - 20℃; for 4.66667h; Stage #2: With sodium hydroxide In dichloromethane; water pH=9;	100%
With 1-butyl-3-methylpyridinium tribromide at 20℃;	97%
With bromine; iodine; acetic acid at 0 - 10℃; Reagent/catalyst; Temperature;	95.2%

: 7463-30-1
N-(2-pyridyl-3-methyl)acetamide

: 3430-21-5
5-bromo-3-methyl-pyridin-2-ylamine

Conditions

Conditions	Yield
Stage #1: N-(2-pyridyl-3-methyl)acetamide With bromine at 55℃; for 2.5h; Stage #2: With sodium hydroxide In water for 0.5h; Temperature;
Stage #1: N-(2-pyridyl-3-methyl)acetamide With bromine at 55℃; for 2.5h; Stage #2: With water; sodium hydroxide for 0.5h; Temperature;

: 3430-21-5
5-bromo-3-methyl-pyridin-2-ylamine

: 122-51-0
orthoformic acid triethyl ester

: ethyl N-(5-bromo-3-methylpyridin-2-yl)carboximidate

Conditions

Conditions	Yield
With toluene-4-sulfonic acid at 85℃; for 1h; Temperature;	99%

: 3430-21-5
5-bromo-3-methyl-pyridin-2-ylamine

: 3430-18-0
2,5-dibromo-3-methylpyridine

Conditions

Conditions	Yield
With hydrogen bromide; bromine; sodium nitrite In water at -15℃; for 3h;	94%
With hydrogen bromide; bromine; sodium nitrite In water at -15 - 23℃; for 3h;	94%
Stage #1: 5-bromo-3-methyl-pyridin-2-ylamine With hydrogen bromide; bromine at -15 - -10℃; Stage #2: With sodium nitrite at 15 - 20℃; Temperature;	91.8%

: 100-39-0
benzyl bromide

: 3430-21-5
5-bromo-3-methyl-pyridin-2-ylamine

: 2-dibenzylamino-5-bromo-3-methylpyridine

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran; N,N-dimethyl acetamide at 0℃; for 16h;	94%

: 3430-21-5
5-bromo-3-methyl-pyridin-2-ylamine

: 166266-19-9
2-amino-3-methyl-5-iodopyridine

Conditions

Conditions	Yield
With copper(l) iodide; 2,3-dimethyl-2,3-diaminobutane; sodium iodide In 1,4-dioxane at 110℃;	93%

: 38202-27-6
ethyl O-(2-mesitylenesulfonyl)acetohydroxamate

: 3430-21-5
5-bromo-3-methyl-pyridin-2-ylamine

: 5-bromo-3-methyl-1λ4-pyridine-1,2-diamine 2,4,6-trimethylbenzenesulfonate

Conditions

Conditions	Yield
Stage #1: ethyl O-(2-mesitylenesulfonyl)acetohydroxamate With perchloric acid In 1,4-dioxane at 0 - 20℃; for 0.5h; Stage #2: 5-bromo-3-methyl-pyridin-2-ylamine In dichloromethane at 0 - 20℃; for 1h;	93%

: 79424-03-6
ethyl 4,4,4-trifluoro-2-butynate

: 3430-21-5
5-bromo-3-methyl-pyridin-2-ylamine

: 7-bromo-9-methyl-4-trifluoromethylpyrido[1,2-a]pyrimidin-2-one

Conditions

Conditions	Yield
In ethanol at 20℃; for 7h; Inert atmosphere;	85%

: 3430-21-5
5-bromo-3-methyl-pyridin-2-ylamine

: 149-73-5
trimethyl orthoformate

: (E)-(ethyl N-(5-bromo-3-methylpyridin-2-yl)carboximidate)

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In dichloromethane for 16h; Reflux; Industrial scale;	84.4%

: 3430-21-5
5-bromo-3-methyl-pyridin-2-ylamine

: 89488-30-2
5-bromo-2-hydroxy-3-methyl pyridine

Conditions

Conditions	Yield
With sodium nitrite In dichloromethane; sulfuric acid; water	84%
With sulfuric acid; sodium nitrite In water at 0 - 20℃; for 1.5h;	84%
With sulfuric acid; water; sodium nitrite at 0 - 20℃; for 0.5h;

2-Amino-5-bromo-3-methylpyridine Chemical Properties

Molecular Structure of 2-Amino-5-bromo-3-methylpyridine (CAS NO.3430-21-5):

IUPAC Name: 5-bromo-3-methylpyridin-2-amine
Empirical Formula: C₆H₇BrN₂
Molecular Weight: 187.0372
H bond acceptors: 2
H bond donors: 2
Freely Rotating Bonds: 0
Polar Surface Area: 16.13 Å²
Index of Refraction: 1.617
Molar Refractivity: 41.09 cm³
Molar Volume: 117.3 cm³
Surface Tension: 52 dyne/cm
Density: 1.593 g/cm³
Flash Point: 105 °C
Enthalpy of Vaporization: 48.72 kJ/mol
Boiling Point: 250 °C at 760 mmHg
Vapour Pressure: 0.0222 mmHg at 25°C
Melting point: 88-95 °C(lit.)
Sensitive: Hygroscopic
BRN: 386426
InChI
InChI=1/C6H7BrN2/c1-4-2-5(7)3-9-6(4)8/h2-3H,1H3,(H2,8,9)
Smiles
n1c(c(C)cc(c1)Br)N
Product Categories: Pyridine; Amines and Anilines; Heterocycles; Pyridines, Pyrimidines, Purines and Pteredines; Amines; Pyridines; Heterocyclic Compounds; Chemical Amines; Anilines, Amides & Amines; Bromine Compounds; Miscellaneous Compounds; Bromopyridines; Halopyridines; Bases & Related Reagents; Heterocyclic; Nucleotides; Boronic Acid; C6Heterocyclic Building Blocks; Halogenated Heterocycles; Heterocyclic Building Blocks

2-Amino-5-bromo-3-methylpyridine Safety Profile

Hazard Codes oF 2-Amino-5-bromo-3-methylpyridine (CAS NO.3430-21-5): Xi Irritant
Risk Statements: 36/37/38
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36:Wear suitable protective clothing.
WGK Germany: 3
Hazard Note: Irritant
HazardClass: Irritant

2-Amino-5-bromo-3-methylpyridine Specification

2-Amino-5-bromo-3-methylpyridine , with CAS number of 3430-21-5, can be called 2-pyridinamine, 5-bromo-3-methyl- ; 5-Bromo-3-methylpyridin-2-amine . It is a yellow solid.

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2-Amino-5-bromo-3-methylpyridine

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