Welcome to LookChem.com Sign In|Join Free
  • or
Home > Products >  > 

2-Bromo-6-methylpyridine
Related Products

Hot Products

Basic Information Post buying leads Suppliers Cas Database
Name

2-Bromo-6-methylpyridine

 EINECS 226-173-4
CAS No. 5315-25-3 Density 1.494 g/cm3
PSA 25.78000 LogP 1.54750
Solubility Soluble in chloroform, ethyl aceate. Not miscible or difficult to mix with water. Melting Point N/A
Formula C6H6BrN Boiling Point 199.5 °C at 760 mmHg
Molecular Weight 172.024 Flash Point 74.4 °C
Transport Information N/A Appearance light yellow liquid
Safety 26-36 Risk Codes 36/37/38
Molecular Structure Molecular Structure of 5315-25-3 (2-Bromo-6-methylpyridine) Hazard Symbols IrritantXi
Synonyms

2-Picoline,6-bromo- (6CI,7CI,8CI);2-Bromo-6-picoline;2-Methyl-6-bromopyridine;6-Bromo-2-methylpyridine;6-Bromo-2-picoline;6-Methyl-2-bromopyridine;

Article Data 40

2-Bromo-6-methylpyridine Synthetic route

1824-81-3

2-Amino-6-methylpyridine

5315-25-3

2-bromo-6-methylpyridine

Conditions
ConditionsYield
Stage #1: 2-Amino-6-methylpyridine With hydrogen bromide; bromine at -10 - -5℃; for 1.5h;
Stage #2: With sodium nitrite In water at -10 - -5℃; for 1.5h;
Stage #3: With sodium hydroxide In water at -10℃;		95%
Stage #1: 2-Amino-6-methylpyridine With hydrogen bromide at 60 - 62℃; for 1h;
Stage #2: With bromine at -5 - -3℃; for 3h;
Stage #3: With sodium nitrite In water for 3h; Temperature;		93.1%
Stage #1: 2-Amino-6-methylpyridine With bromine at -20℃; for 1.5h;
Stage #2: With sodium nitrite at -20 - 15℃;
Stage #3: With sodium hydroxide at -10 - 20℃; Further stages.;		90%
626-05-1

2,6-Dibromopyridine

917-54-4

methyllithium

5315-25-3

2-bromo-6-methylpyridine

Conditions
ConditionsYield
In diethyl ether at -25 - 0℃; for 4h;59%
18368-63-3

6-chloro-2-picoline

5315-25-3

2-bromo-6-methylpyridine

Conditions
ConditionsYield
With trimethylsilyl bromide In various solvent(s) for 100h; Heating;47%
3279-76-3

6-hydroxy-2-methylpyridine

5315-25-3

2-bromo-6-methylpyridine

Conditions
ConditionsYield
With phosphorus(V) oxybromide
3279-76-3

6-hydroxy-2-methylpyridine

A

5315-25-3

2-bromo-6-methylpyridine

B

3430-15-7

2,3,5-tribromo-6-methyl-pyridine

Conditions
ConditionsYield
With phosphorus pentabromide at 160℃;
3279-76-3

6-hydroxy-2-methylpyridine

phosphorus yl bromide

phosphorus yl bromide

5315-25-3

2-bromo-6-methylpyridine

Conditions
ConditionsYield
at 160℃;
1824-81-3

2-Amino-6-methylpyridine

10035-10-6, 12258-64-9

hydrogen bromide

aqueous NaNO2

aqueous NaNO2

A

5315-25-3

2-bromo-6-methylpyridine

B

500587-45-1

3,5-dibromo-2-hydroxy-6-methylpyridine

3279-76-3

6-hydroxy-2-methylpyridine

7789-69-7

phosphorus pentabromide

A

5315-25-3

2-bromo-6-methylpyridine

B

2,3(?),5(?)-tribromo-6-methyl-pyridine(mp: 75-76 degree )

2,3(?),5(?)-tribromo-6-methyl-pyridine(mp: 75-76 degree )

Conditions
ConditionsYield
at 160℃;
109-06-8

α-picoline

5315-25-3

2-bromo-6-methylpyridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: NaNH2; xylene
2: aqueous hydrobromic acid / Behandeln mit Brom und mit wss. Natriumnitrit-Loesung
View Scheme
626-05-1

2,6-Dibromopyridine

74-88-4

methyl iodide

5315-25-3

2-bromo-6-methylpyridine

Conditions
ConditionsYield
Stage #1: 2,6-Dibromopyridine With n-butyllithium In tetrahydrofuran; hexane at 0℃; for 1.52778E-05h;
Stage #2: methyl iodide In tetrahydrofuran; hexane at 0℃; for 0.0025h;		94 %Chromat.
Stage #1: 2,6-Dibromopyridine With n-butyllithium In hexane at 0℃; for 1.52778E-05h;
Stage #2: methyl iodide In tetrahydrofuran; hexane at 0℃; for 0.0025h;		94 %Chromat.

2-Bromo-6-methylpyridine Specification

The 2-Bromo-6-Methyl pyridine is an organic compound with the formula C6H6BrN. The IUPAC name of this chemical is 2-bromo-6-methylpyridine. With the CAS registry number 5315-25-3, it is also named as Pyridine, 2-bromo-6-methyl-. The product's categories are Compounds of Pyridine; Blocks; Bromides; Pyridines; Pyridine; Pyridine Derivative; Halides; Heterocycles; Pyridines, Pyrimidines, Purines and Pteredines; Bromopyridines; Halopyridines; Boronic Acid; C6Heterocyclic Building Blocks; Halogenated Heterocycles; Heterocyclic Building Blocks. Besides, it is light yellow liquid, which should be stored in a dark cool and dry place.

Physical properties about 2-Bromo-6-Methyl pyridine are: (1)ACD/LogP: 1.99; (2)ACD/LogD (pH 5.5): 1.99; (3)ACD/LogD (pH 7.4): 1.99; (4)ACD/BCF (pH 5.5): 19.2; (5)ACD/BCF (pH 7.4): 19.2; (6)ACD/KOC (pH 5.5): 288.5; (7)ACD/KOC (pH 7.4): 288.53; (8)#H bond acceptors: 1; (9)Polar Surface Area: 12.89 Å2; (10)Index of Refraction: 1.553; (11)Molar Refractivity: 36.85 cm3; (12)Molar Volume: 115.1 cm3; (13)Polarizability: 14.61×10-24cm3; (14)Surface Tension: 40 dyne/cm; (15)Density: 1.494 g/cm3; (16)Flash Point: 74.4 °C; (17)Enthalpy of Vaporization: 41.79 kJ/mol; (18)Boiling Point: 199.5 °C at 760 mmHg; (19)Vapour Pressure: 0.482 mmHg at 25°C.

Preparation: this chemical can be prepared by 6-methyl-pyridin-2-ylamine. This reaction will need reagent HBr and NaNO2. The reaction temperature is -20 °C.



Uses of 2-Bromo-6-Methyl pyridine: it can be used to produce 6,6'-dimethyl-[2,2']bipyridinyl. It will need reagent Ni[P(C6H5)3]4. The yield is about 84%.

When you are using this chemical, please be cautious about it as the following:
This chemical is irritating to eyes, respiratory system and skin. When you are using it, wear suitable protective clothing. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1)SMILES: Cc1cccc(n1)Br
(2)InChI: InChI=1/C6H6BrN/c1-5-3-2-4-6(7)8-5/h2-4H,1H3
(3)InChIKey: SOHDPICLICFSOP-UHFFFAOYAL
(4)Std. InChI: InChI=1S/C6H6BrN/c1-5-3-2-4-6(7)8-5/h2-4H,1H3
(5)Std. InChIKey: SOHDPICLICFSOP-UHFFFAOYSA-N

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 5315-25-3