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Cas Database |
| Name |
2-Chloro-1-(difluoromethoxy)-1,1,2-trifluoroethane |
EINECS | N/A | |
| CAS No. | 13838-16-9 | Density | 1.489g/cm3 | |
| PSA | 9.23000 | LogP | 2.35280 | |
| Solubility | N/A | Melting Point |
N/A |
|
| Formula | C3H2 Cl F5 O | Boiling Point | 59.9°Cat760mmHg | |
| Molecular Weight | 184.493 | Flash Point | °C | |
| Transport Information | N/A | Appearance | N/A | |
| Safety | Mildly toxic by inhalation, ingestion, and subcutaneous routes. Human systemic effects by inhalation: decreased urine volume or anuria. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. An eye irritant. Questionable carcinogen with experimental carcinogenic data. An anesthetic. When heated to decomposition it emits very toxic fumes of F− and Cl−. See also ETHERS. | |||
Analytical Methods: | For occupational chemical analysis use OSHA: #29. |
Risk Codes | 36 | |
| Molecular Structure |
|
Hazard Symbols | Volatile with anesthetic properties, but nonflammable. TLV: 75 ppm; not classifiable as a human carcinogen. | |
| Synonyms |
Ether,2-chloro-1,1,2-trifluoroethyl difluoromethyl (8CI); (?à)-Enflurane;2-Chloro-1,1,2-trifluoro-1-difluoromethoxyethane; 2-Chloro-1,1,2-trifluoroethyldifluoromethyl ether; 347; Alyrane; Anesthetic Compound No. 347; Compound 347;Efrane; Enflurane; Ethrane; Methylflurether; NSC 115944; Ohio 347; R-E 235ca2 |
Article Data | 8 |
2-Chloro-1-(difluoromethoxy)-1,1,2-trifluoroethane Synthetic route
- 428-96-6
(2-chloro-1,1,2-trifluoroethyl)dichloromethylether
- 13838-16-9
enflurane
| Conditions | Yield |
|---|---|
| With hydrogen fluoride; antimonypentachloride at 0℃; |
- 627-42-9
2-chloroethyl methyl ether
A
- 5073-63-2
2-Chloro-1,1,2-trifluoroethyl fluoromethyl ether
B
- 13838-16-9
enflurane
| Conditions | Yield |
|---|---|
| With potassium tetrafluorocobaltate at 250℃; Yield given. Further byproducts given. Yields of byproduct given; |
- 13838-16-9
enflurane
- 31702-61-1
1,1,2-Trifluor-2-chlor-2-bromethyldifluormethylether
| Conditions | Yield |
|---|---|
| With bromine at 450 - 475℃; |
- 13838-16-9
enflurane
- 32778-14-6
2,2-Dichlortrifluorethyldifluormethylether
| Conditions | Yield |
|---|---|
| With chlorine Irradiation; |
- 25600-63-9
1,1-difluoro-2,2-dichloroethyl difluoromethyl ether
- 13838-16-9
enflurane
- 70006-57-4
1,1-difluoro-2-deutero-2,2-dichloroethyl difluoromethyl ether
| Conditions | Yield |
|---|---|
| With sodium hydroxide; bromine In water |
2-Chloro-1-(difluoromethoxy)-1,1,2-trifluoroethane Chemical Properties
IUPAC Name: 2-Chloro-1-(difluoromethoxy)-1,1,2-trifluoroethane
The MF of 2-Chloro-1-(difluoromethoxy)-1,1,2-trifluoroethane (CAS NO.13838-16-9) is C3H2ClF5O.
The MW of 2-Chloro-1-(difluoromethoxy)-1,1,2-trifluoroethane (CAS NO.13838-16-9) is 184.49.
Synonyms of 2-Chloro-1-(difluoromethoxy)-1,1,2-trifluoroethane (CAS NO.13838-16-9): (2-Chloro-1,1,2-trifluoro-ethoxy)-difluoro-methane ; 2-Chloro-1-(difluoromethoxy)-1,1,2-trifluoro-ethan ; 2-Chloro-1,1,2-difluoroethane, 1-difluoromethoxy- ; 347 ; Alyrane
Apperance: a clear, colorless, odorless to sweet, volatile liquid
Index of Refraction: 1.301
EINECS: 237-553-4
Density: 1.489 g/ml
Flash Point: 56-57 °C
Boiling Point: 59.9 °C
Merck: 14,3581
BRN: 1737129
2-Chloro-1-(difluoromethoxy)-1,1,2-trifluoroethane Uses
Enflurane and Methoxyflurane have a nephrotoxic effect and cause acute renal failure usually by its nephrotoxic metabolite.
2-Chloro-1-(difluoromethoxy)-1,1,2-trifluoroethane Toxicity Data With Reference
| 1. | eye-rbt 100 mg MOD | FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. 35 (1976),729. | ||
| 2. | cyt-hmn:lyms 1000 ppm | ENVRAL Environmental Research. 12 (1976),366. | ||
| 3. | cyt-mus:fbr 1000 ppm | ENVRAL Environmental Research. 12 (1976),366. | ||
| 4. | ihl-hmn TCLo:1 pph/6H | ANESAV Anesthesiology. 45 (1976),557. | ||
| 5. | orl-rat LD50:5450 mg/kg | DRUGAY Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. 6 (1982),143. | ||
| 6. | ihl-rat LC50:14,000 ppm/3H | IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 12 (1981),668. | ||
| 7. | ipr-rat LD50:6 g/kg | DRUGAY Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. 6 (1982),143. | ||
| 8. | scu-rat LD50:19,500 mg/kg | YKYUA6 Yakkyoku. Pharmacy. 32 (1981),491. | ||
| 9. | orl-mus LD50:5 g/kg | DRUGAY Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. 6 (1982),143. | ||
| 10. | ihl-mus LC50:8100 ppm/3H | IYKEDH Iyakuhin Kenkyu. Study of |
2-Chloro-1-(difluoromethoxy)-1,1,2-trifluoroethane Consensus Reports
Reported in EPA TSCA Inventory.
2-Chloro-1-(difluoromethoxy)-1,1,2-trifluoroethane Safety Profile
Mildly toxic by inhalation, ingestion, and subcutaneous routes. Human systemic effects by inhalation: decreased urine volume or anuria. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. An eye irritant. Questionable carcinogen with experimental carcinogenic data. An anesthetic. When heated to decomposition it emits very toxic fumes of F− and Cl−. See also ETHERS.Safety information of 2-Chloro-1-(difluoromethoxy)-1,1,2-trifluoroethane (CAS NO.13838-16-9):
Hazard Codes 
F,
T
Risk Statements
36 Irritating to the eyes
Safety Statements
23 Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer)
26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36 Wear suitable protective clothing
RTECS KN6800000
Hazard Note Flammable/Toxic
2-Chloro-1-(difluoromethoxy)-1,1,2-trifluoroethane Standards and Recommendations
ACGIH TLV: TWA 75 ppm; Not Classifiable as a Human Carcinogen
DFG MAK: 20 ppm
NIOSH REL: (Waste Anesthetic Gases and Vapors) CL 2 ppm/1H
2-Chloro-1-(difluoromethoxy)-1,1,2-trifluoroethane Analytical Methods
For occupational chemical analysis use OSHA: #29.
2-Chloro-1-(difluoromethoxy)-1,1,2-trifluoroethane Specification
Enflurane and Methoxyflurane have a nephrotoxic effect and cause acute renal failure usually by its nephrotoxic metabolite.It is incompatible with the following oxidizing materials, peroxides, combustible materials. Although nonflammable, a fire may cause it to decompose to toxic compounds including phosgene, hydrogen chloride, and hydrogen fluoride. Decomposes slowly in the light.
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