Welcome to LookChem.com Sign In|Join Free
  • or
Home > Products >  > 

2-Chloro-6-fluoronitrobenzene

Related Products

Hot Products

Name

2-Chloro-6-fluoronitrobenzene

EINECS 264-723-5
CAS No. 64182-61-2 Density 1.494 g/cm3
PSA 45.82000 LogP 2.91050
Solubility N/A Melting Point N/A
Formula C6H3ClFNO2 Boiling Point 245.1 °C at 760 mmHg
Molecular Weight 175.547 Flash Point 102 °C
Transport Information N/A Appearance N/A
Safety Risk Codes N/A
Molecular Structure Molecular Structure of 64182-61-2 (2-Chloro-6-fluoronitrobenzene) Hazard Symbols IrritantXi
Synonyms

1-Chloro-3-fluoro-2-nitrobenzene;2-Chloro-6-fluoronitrobenzene;AC1MI4VG;MolPort-001-772-764;AC-237;SBB055342;ZINC16158176;CID3017500;

Article Data 4

2-Chloro-6-fluoronitrobenzene Synthetic route

2-chloro-4-fluoro-3-nitrobenzoic acid

64182-61-2

1-chloro-3-fluoro-2-nitrobenzene

Conditions
ConditionsYield
With sulfolane; sodium hydrogencarbonate at 195℃; for 2h; Temperature; Reagent/catalyst;92%
363-51-9

2-chloro-6-fluoroaniline

64182-61-2

1-chloro-3-fluoro-2-nitrobenzene

Conditions
ConditionsYield
Stage #1: 2-chloro-6-fluoroaniline With tetrafluoroboric acid; sodium nitrite at 0℃; for 0.5h;
Stage #2: With copper; sodium nitrite at 20℃; for 1h; Further stages.;
44%
59772-34-8

2-chloro-6-fluoroaniline hydrochloride

64182-61-2

1-chloro-3-fluoro-2-nitrobenzene

Conditions
ConditionsYield
With hydrogenchloride; sodium nitrite In water
64182-61-2

1-chloro-3-fluoro-2-nitrobenzene

62-53-3

aniline

(3-chloro-2-nitro-phenyl)-phenyl-amine

Conditions
ConditionsYield
Stage #1: aniline With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; for 0.5h; Inert atmosphere;
Stage #2: 1-chloro-3-fluoro-2-nitrobenzene In tetrahydrofuran at -78 - 20℃;
Stage #3: With ammonium chloride In tetrahydrofuran; water
100%
With potassium tert-butylate In dimethyl sulfoxide at 20℃; for 3h;
64182-61-2

1-chloro-3-fluoro-2-nitrobenzene

75-04-7

ethylamine

3-chloro-N-ethyl-2-nitroaniline

Conditions
ConditionsYield
at 40℃; for 16h;98%
64182-61-2

1-chloro-3-fluoro-2-nitrobenzene

108-95-2

phenol

104272-69-7

1-chloro-2-nitro-3-phenoxybenzene

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 100℃;98%
64182-61-2

1-chloro-3-fluoro-2-nitrobenzene

17802-02-7

2-nitro-3-chlorophenol

Conditions
ConditionsYield
With lithium hydroxide; dihydrogen peroxide In tetrahydrofuran; water at 60℃; for 72h;97%
Stage #1: 1-chloro-3-fluoro-2-nitrobenzene With lithium hydroxide; water; dihydrogen peroxide In tetrahydrofuran at 60℃; for 72h; Sealed vessel;
Stage #2: With hydrogenchloride In tetrahydrofuran; water pH=< 3;
97%
Stage #1: 1-chloro-3-fluoro-2-nitrobenzene With lithium hydroxide; water; dihydrogen peroxide In tetrahydrofuran at 60℃; for 72h; Sealed;
Stage #2: With hydrogenchloride In tetrahydrofuran; water pH=< 3;
97%
64182-61-2

1-chloro-3-fluoro-2-nitrobenzene

87120-72-7

1-(tert-butoxycarbonyl)-4-aminopiperidine

tert-butyl 4-((3-chloro-2-nitrophenyl)amino)piperidine-1-carboxylate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; Inert atmosphere;93%
With potassium carbonate In dimethyl sulfoxide at 20℃; Inert atmosphere;
95-20-5

2-methyl-1H-indole

64182-61-2

1-chloro-3-fluoro-2-nitrobenzene

1-(3-chloro-2-nitrophenyl)-2-methyl-1H-indole

Conditions
ConditionsYield
With sodium hydroxide In dimethyl sulfoxide at 20℃; for 4h;90%

1-[trans-4-(methyloxy)-1-methylcyclohexyl]-4-piperidinamine dihydrochloride

64182-61-2

1-chloro-3-fluoro-2-nitrobenzene

950773-08-7

N-(5-chloro-2-nitrophenyl)-1-[trans-1-methyl-4-(methyloxy)cyclohexyl]-4-piperidinamine

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20 - 110℃; for 1h; Microwave reactor;85%

2-Chloro-6-fluoronitrobenzene Specification

The Benzene,1-chloro-3-fluoro-2-nitro- with CAS registry number of 64182-61-2 is also known as 2-Chloro-6-fluoronitrobenzene. The IUPAC name is 1-Chloro-3-fluoro-2-nitrobenzene. Its EINECS registry number is 264-723-5. In addition, the formula is C6H3ClFNO2 and the molecular weight is 175.54.

Physical properties of Benzene,1-chloro-3-fluoro-2-nitro-: (1)ACD/LogP: 1.64; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.64; (4)ACD/LogD (pH 7.4): 1.64; (5)ACD/BCF (pH 5.5): 10.31; (6)ACD/BCF (pH 7.4): 10.31; (7)ACD/KOC (pH 5.5): 184.88; (8)ACD/KOC (pH 7.4): 184.88; (9)#H bond acceptors: 3; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 45.82 Å2; (13)Index of Refraction: 1.554; (14)Molar Refractivity: 37.68 cm3; (15)Molar Volume: 117.4 cm3; (16)Polarizability: 14.94×10-24cm3; (17)Surface Tension: 45.9 dyne/cm; (18)Enthalpy of Vaporization: 46.26 kJ/mol; (19)Vapour Pressure: 0.0459 mmHg at 25 °C.

Preparation of Benzene,1-chloro-3-fluoro-2-nitro-: it is prepared by reaction of 2-chloro-6-fluoro-aniline. The reaction needs reagents aq. fluoboric acid, sodium nitrite, aq. sodium nitrite and copper. The reaction has two steps, one step occurs at 0 °C for 30 minutes and another step occurs at the temperature of 20 °C for 1 hour. The yield is about 44%.

Benzene,1-chloro-3-fluoro-2-nitro- is prepared by reaction of 2-chloro-6-fluoro-aniline.

Uses of Benzene,1-chloro-3-fluoro-2-nitro-: it is used to produce (2-chloro-6-fluoro-phenyl)-carbamic acid ethyl ester by reaction with carbonochloridic acid ethyl ester. The reaction occurs with reagents Sn, NH4Cl and solvent methanol with other condition of sonication for 3.5 hours at 25 °C. The yield is about 80%.

Benzene,1-chloro-3-fluoro-2-nitro- is used to produce (2-chloro-6-fluoro-phenyl)-carbamic acid ethyl ester by reaction with carbonochloridic acid ethyl ester.

You can still convert the following datas into molecular structure:
(1)SMILES: O=[N+]([O-])c1c(F)cccc1Cl
(2)InChI: InChI=1/C6H3ClFNO2/c7-4-2-1-3-5(8)6(4)9(10)11/h1-3H
(3)InChIKey: GOIUPLBHNRTTIO-UHFFFAOYAP
(4)Std. InChI: InChI=1S/C6H3ClFNO2/c7-4-2-1-3-5(8)6(4)9(10)11/h1-3H
(5)Std. InChIKey: GOIUPLBHNRTTIO-UHFFFAOYSA-N

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 64182-61-2