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Cas Database |
| Name |
2-Chloro-6-aminopyrazine |
EINECS | 206-027-6 |
| CAS No. | 33332-28-4 | Density | 1.437 g/cm3 |
| PSA | 51.80000 | LogP | 1.29340 |
| Solubility | N/A | Melting Point |
150-152 °C |
| Formula | C4H4ClN3 | Boiling Point | 282.8 °C at 760 mmHg |
| Molecular Weight | 129.549 | Flash Point | 124.8 °C |
| Transport Information | N/A | Appearance | Colorless or off-white solid |
| Safety | 26-36/37/39 | Risk Codes | 36/37/38 |
| Molecular Structure |
|
Hazard Symbols |
 Xi
|
| Synonyms |
2-Pyrazinamine,6-chloro-;Pyrazinamine,6-chloro- (9CI);Pyrazine, 2-amino-6-chloro- (7CI,8CI);2-Amino-6-chloropyrazine;6-Amino-2-chloropyrazine;6-Chloro-2-aminopyrazine;6-Chloro-2-pyrazinamine;6-Chloro-2-pyrazinylamine; |
Article Data | 17 |
2-Chloro-6-aminopyrazine Synthetic route
- 4774-14-5
2,6-dichloropyrazine
- 33332-28-4
2-amino-6-chloropyrazine
| Conditions | Yield |
|---|---|
| With ammonia at 100℃; for 5h; Temperature; | 95% |
| With ammonia In water at 100℃; Inert atmosphere; sealed tube; | 91% |
| With ammonia In water at 100℃; for 18h; Sealed tube; | 91% |
- 355836-31-6
6-chloro-N-(4-methoxybenzyl)pyrazin-2-amine
- 33332-28-4
2-amino-6-chloropyrazine
| Conditions | Yield |
|---|---|
| In trifluoroacetic acid | 77% |
- 6863-77-0
3-aminopyrazine 1-oxide
A
- 6863-73-6
3-chloropyrazin-2-amine
B
- 33332-29-5
2-amino-5-chloropyrazine
C
- 33332-28-4
2-amino-6-chloropyrazine
| Conditions | Yield |
|---|---|
| With trichlorophosphate for 2h; Heating; Yield given. Yields of byproduct given. Title compound not separated from byproducts; | |
| With trichlorophosphate for 2h; Product distribution; Mechanism; Heating; other substituted pyrazine-1-oxides and products, deoxygenation/chlorination competition; other time; |
| Conditions | Yield |
|---|---|
| With palladium diacetate; potassium carbonate; triphenylphosphine In ethanol; toluene at 100℃; Inert atmosphere; | 100% |
| With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate In 1,4-dioxane; water at 20 - 90℃; for 16.1667h; Reagent/catalyst; Temperature; Solvent; Inert atmosphere; | 83% |
| With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate In 1,4-dioxane; water at 90℃; for 16h; Inert atmosphere; | 83% |
| With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate In 1,4-dioxane; water at 90℃; for 16h; Inert atmosphere; | 83% |
| With potassium phosphate; 1,1'-bis(di-tertbutylphosphino)ferrocene; palladium diacetate In 1,4-dioxane at 100℃; for 5h; Suzuki coupling; Inert atmosphere; Sealed tube; | 55% |
- 1765-93-1
4-fluoroboronic acid
- 33332-28-4
2-amino-6-chloropyrazine
- 1159815-52-7
6-(4-fluoro-phenyl)-pyrazin-2ylamine
| Conditions | Yield |
|---|---|
| With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; sodium carbonate In 1,4-dioxane; water at 20℃; for 20h; Reflux; | 100% |
| With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium carbonate In 1,4-dioxane; water at 90℃; for 16h; Inert atmosphere; | 68% |
| With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium carbonate In 1,4-dioxane; water at 90℃; for 16h; Inert atmosphere; | 68% |
| With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate In 1,4-dioxane; water at 95℃; for 12h; Inert atmosphere; |
- 3143-02-0
3-hydroxymethyl-3-methyloxethane
- 33332-28-4
2-amino-6-chloropyrazine
- 1431654-81-7
6-((3-methyloxetan-3-yl)methoxy)pyrazin-2-amine
| Conditions | Yield |
|---|---|
| Stage #1: 3-hydroxymethyl-3-methyloxethane With sodium hydride In 1,4-dioxane; mineral oil at 20℃; for 2h; Stage #2: 2-amino-6-chloropyrazine for 16h; Reflux; | 100% |
| Stage #1: 3-hydroxymethyl-3-methyloxethane With sodium hydride In 1,4-dioxane; mineral oil at 20℃; for 2h; Stage #2: 2-amino-6-chloropyrazine In 1,4-dioxane; mineral oil for 16h; Reflux; | 100% |
- 24424-99-5
di-tert-butyl dicarbonate
- 33332-28-4
2-amino-6-chloropyrazine
- 815610-07-2
N-(tert-butoxycarbonyl)-N-(6-chloropyrazin-2-yl) tert-butylcarbamate
| Conditions | Yield |
|---|---|
| With dmap In tetrahydrofuran at 20℃; for 2h; | 98% |
| With dmap In dichloromethane at 20℃; for 3h; | 98% |
| With dmap In tetrahydrofuran at 20℃; for 8h; | 88.4% |
- 33332-28-4
2-amino-6-chloropyrazine
- 960510-36-5
2-amino-5-bromo-3,6-dichloropyrazine
| Conditions | Yield |
|---|---|
| Stage #1: 2-amino-6-chloropyrazine With N-Bromosuccinimide In methanol at 50℃; for 19h; Stage #2: With N-chloro-succinimide In methanol at 38 - 50℃; for 16h; | 97% |
| Stage #1: 2-amino-6-chloropyrazine With N-Bromosuccinimide In methanol at 50℃; for 19h; Stage #2: With N-chloro-succinimide In methanol at 38 - 50℃; for 16h; | 97% |
| Stage #1: 2-amino-6-chloropyrazine With N-Bromosuccinimide In methanol at 50℃; for 19h; Stage #2: With N-chloro-succinimide In methanol at 38 - 50℃; for 16h; | 97% |
| Stage #1: 2-amino-6-chloropyrazine With N-Bromosuccinimide In methanol at 50℃; for 19h; Stage #2: With N-chloro-succinimide at 50℃; for 16h; | 97% |
| Stage #1: 2-amino-6-chloropyrazine With N-Bromosuccinimide In methanol for 17h; Stage #2: With N-chloro-succinimide; N-Bromosuccinimide In methanol at 38 - 50℃; for 18h; | 97% |
- 33332-28-4
2-amino-6-chloropyrazine
- 1711-06-4
3-Methylbenzoyl chloride
- 1194688-06-6
N-(6-chloropyrazin-2-yl)-3-methylbenzamide
| Conditions | Yield |
|---|---|
| With pyridine at 100℃; for 16h; | 97% |
- 33332-28-4
2-amino-6-chloropyrazine
- 925678-00-8
6-chloro-5-iodo-pyrazin-2-ylamine
| Conditions | Yield |
|---|---|
| With N-iodo-succinimide In dimethyl sulfoxide at 25℃; | 88% |
| With N-iodo-succinimide In dimethyl sulfoxide at 20℃; for 72h; | 80% |
| With N-iodo-succinimide In dimethyl sulfoxide at 20℃; for 72h; | 80% |
2-Chloro-6-aminopyrazine Chemical Properties
Molecular Structure of 4-Bromo-1,2-pyrazolidinedicarboxaldehyde (CAS NO.162887-23-2):
.png)
IUPAC Name: 6-chloropyrazin-2-amine
Empirical Formula: C4H4ClN3
Molecular Weight: 129.5477
H bond acceptors: 3
H bond donors: 2
Freely Rotating Bonds: 0
Polar Surface Area: 29.02 Å2
Molar Refractivity: 31.56 cm3
Molar Volume: 90.1 cm3
Surface Tension: 66.4 dyne/cm
Index of Refraction: 1.617
Surface Tension: 66.4 dyne/cm
Melting Point：150-152 °C
Density: 1.437 g/cm3
Flash Point: 124.8 °C
Enthalpy of Vaporization: 52.16 kJ/mol
Boiling Point: 282.8 °C at 760 mmHg
Vapour Pressure: 0.00329 mmHg at 25°C
Melting point: 150-152°C
Product Categories: Nitrogen cyclic compounds; Amines; blocks; Pyrazines, Pyrimidines & Pyridazines; Pyrazine; Pyrazines; Pyrazines, Pyrimidines & Pyridazines
2-Chloro-6-aminopyrazine Safety Profile
Hazard Codes: 
Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36/37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
HazardClass: irritant
2-Chloro-6-aminopyrazine Specification
2-Chloro-6-aminopyrazine , its cas register number is 33332-28-4. It also can be called 2-pyrazinamine, 6-chloro- ; 6-Chloro-2-pyrazinamine ; 2-Amino-6-Chloro Pyrazine ; Pyrazinamine,6-chloro- (9CI) ; Pyrazine, 2-amino-6-chloro- (7CI,8CI) ; 6-Chloro-2-pyrazinylamine ; 6-Chloro-2-aminopyrazine . 2-Amino-6-chloropyrazine (CAS NO.33332-28-4) can be used as pharmaceutical intermediates.
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