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Cas Database

Name	2-Methoxy-5-fluorouracil	EINECS	473-810-9
CAS No.	1480-96-2	Density	1.44 g/cm³
PSA	55.24000	LogP	0.32990
Solubility	5.49g/L at 20℃	Melting Point	204-208 °C(lit.)
Formula	C₅H₅FN₂O₂	Boiling Point	225.1℃[at 101 325 Pa]
Molecular Weight	144.105	Flash Point	N/A
Transport Information	N/A	Appearance	N/A
Safety	26-36	Risk Codes	36/37/38
Molecular Structure		Hazard Symbols	Xi
Synonyms	4(1H)-Pyrimidinone,5-fluoro-2-methoxy- (9CI);4(3H)-Pyrimidinone, 5-fluoro-2-methoxy- (6CI,8CI);NSC 527067;	Article Data	5

2-Methoxy-5-fluorouracil Synthetic route

potassium-compound of 2-fluoro-3-oxo-propionic acid ethyl ester: potassium-compound of 2-fluoro-3-oxo-propionic acid ethyl ester

O-methyl-uronium chloride: O-methyl-uronium chloride

: 1480-96-2
2-methoxy-5-fluorouracil

: 64-17-5
ethanol

: 124-41-4
sodium methylate

: 5329-33-9
o-methylisourea hydrochloride

potassium-compound of 2-fluoro-3-hydroxy-acrylic acid ethyl ester: potassium-compound of 2-fluoro-3-hydroxy-acrylic acid ethyl ester

: 1480-96-2
2-methoxy-5-fluorouracil

: O-methylisourea hemisulphate

: 453-18-9
methyl fluoroacetate

: 109-94-4
formic acid ethyl ester

: 1480-96-2
2-methoxy-5-fluorouracil

Conditions

Conditions	Yield
Stage #1: formic acid ethyl ester With sodium methylate In toluene at 10 - 20℃; Large scale; Stage #2: methyl fluoroacetate In toluene at 8 - 40℃; for 20h; Large scale; Stage #3: O-methylisourea hydrosulfate With sodium methylate In methanol at 40℃; for 6h; Large scale;

: 1480-96-2
2-methoxy-5-fluorouracil

: 1801-06-5
2-methoxy-4-chloro-5-fluoropyrimidine

Conditions

Conditions	Yield
With triethylamine; trichlorophosphate In toluene at 50 - 80℃;	95%
With N,N-dimethyl-aniline; trichlorophosphate at 110℃; for 1.5h;	34%

: 1480-96-2
2-methoxy-5-fluorouracil

: 51-21-8
5-fluorouracil

Conditions

Conditions	Yield
With hydrogenchloride In methanol at 28℃; for 5h; Temperature;	78.3%
With hydrogenchloride In water at 55℃; for 3h; Large scale;	65.24 kg

2-Methoxy-5-fluorouracil Chemical Properties

Molecular structure of 2-Methoxy-5-fluorouracil (CAS NO.1480-96-2) is:

Product Name: 2-Methoxy-5-fluorouracil
CAS Registry Number: 1480-96-2
IUPAC Name: 5-fluoro-2-methoxy-1H-pyrimidin-6-one
Molecular Weight: 144.103803 [g/mol]
Molecular Formula: C₅H₅FN₂O₂
XLogP3-AA: 0
H-Bond Donor: 1
H-Bond Acceptor: 4
Melting Point: 204-208 °C(lit.)
Index of Refraction: 1.536
Molar Refractivity: 31.06 cm³
Molar Volume: 99.5 cm³
Surface Tension: 39.4 dyne/cm
Density: 1.44 g/cm³
Product Categories: PYRIMIDINE;Pyridines, Pyrimidines, Purines and Pteredines;INTERMEDIATESOFFINASTERIDE;Heterocyclic Compounds;Bases & Related Reagents;Heterocycles;Nucleotides;Building Blocks;Heterocyclic Building Blocks;Pyrimidines

2-Methoxy-5-fluorouracil Safety Profile

Safty information about 2-Methoxy-5-fluorouracil (CAS NO.1480-96-2) is:
Hazard Codes: Irritant Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
WGK Germany: 3

2-Methoxy-5-fluorouracil Specification

2-Methoxy-5-fluorouracil , its cas register number is 1480-96-2. It also can be called 4(3H)-Pyrimidinone,5-fluoro-2-methoxy- ; 5-Fluoro-2-methoxy-4(1H)pyrimidinone .

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