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2-Methylaziridine

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Name

2-Methylaziridine

EINECS 200-878-7
CAS No. 75-55-8 Density 0.8
PSA 21.94000 LogP 0.30690
Solubility Miscible with water Melting Point -65 ºC
Formula C3H7 N Boiling Point 66.5 °C at 760 mmHg
Molecular Weight 57.0953 Flash Point -4 ºC
Transport Information UN 1921 Appearance colorless liquid
Safety 53-45-61 Risk Codes R45;R11;R26/27/28;R41;R51/53   
Molecular Structure Molecular Structure of 75-55-8 (2-Methylaziridine) Hazard Symbols F;T+;N
Synonyms

1,2-Propylenimine;2-Methylaziridine; 2-Methylethylenimine; DL-2-Methylaziridine; NSC 20655;Propylenimine

Article Data 16

2-Methylaziridine Chemical Properties

Molecular Formula:C3H7N
Molecular Weight:57.11
Melting Point: -65°C 
EINECS: 200-878-7
Flash Point: -4°C
Density: 0.824 g/cm3
Refractive index: 1.4125
Water Solubility: miscible  
IUPAC Name: 2-Methylaziridine
Boiling Point: 66.5 °C at 760 mmHg 
Vapour Pressure: 151 mmHg at 25°C 
Appearance: Colorless, oily liquid with an ammonia-like odor
Air & Water Reactions: Soluble in water. Reacts slowly and non hazardously with water to form propanolamine or methylethanolamine.
Stability: Unstable - readily polymerises in the absence of an inhibitor. May polymerize vigorously or explosively in the presence of acids. Flammable. Incompatible with acids, oxidizing agents, quinones, carbonyl compounds, sulfonyl halides, some types of plastic, water.
Synonyms: PI ; Propyleneimine ; 2-Methylaziridine ; (R,S)-2-Methyl-aziridine ; 1,2-Propyleneimine ; 1,2-Propylenimine ; 1,2-Propylenimine(2-methylaziridine) ; 2-Methylazacyclopropane
Following is the molecular structure of Propylenei mine (75-55-8):

 

2-Methylaziridine Uses

 Propylenei mine (75-55-8) is used as an organic intermediate.

2-Methylaziridine Production


Reactivity Profile: Propyleneimine (75-55-8) is subject to violent polymerization on contact with an acid. (The inhibitor is intended to prevent polymerization). Incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated in combination with strong reducing agents, such as hydrides.

2-Methylaziridine Toxicity Data With Reference

1.    

eye-rbt 250 µg open SEV

    JIHTAB    Journal of Industrial Hygiene and Toxicology. 30 (1948),63.
2.    

mmo-sat 3300 ng/plate

    ENMUDM    Environmental Mutagenesis. 6 (Suppl 2)(1984),1.
3.    

mmo-esc 1 µg/plate

    ENMUDM    Environmental Mutagenesis. 6 (Suppl 2)(1984),1.
4.    

orl-rat LD50:19 mg/kg

    JIHTAB    Journal of Industrial Hygiene and Toxicology. 30 (1948),63.
5.    

ihl-rat LCLo:500 ppm/4H

    JIHTAB    Journal of Industrial Hygiene and Toxicology. 31 (1949),343.
6.    

ihl-gpg LCLo:500 ppm/1H

    JIHTAB    Journal of Industrial Hygiene and Toxicology. 30 (1948),2.
7.    

skn-gpg LD50:43 mg/kg

    JIHTAB    Journal of Industrial Hygiene and Toxicology. 30 (1948),63.

2-Methylaziridine Consensus Reports

NTP 10th Report on Carcinogens. IARC Cancer Review: Group 2B IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Limited Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 9 ,1975,p. 61.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . EPA Genetic Toxicology Program. Reported in EPA TSCA Inventory. EPA Extremely Hazardous Substances List. Community Right-To-Know List.

2-Methylaziridine Safety Profile

Confirmed carcinogen with experimental carcinogenic data. Poison by ingestion and skin contact. Moderately toxic by inhalation. Mutation data reported. Severe eye irritant. Implicated as a brain carcinogen. A flammable liquid and very dangerous fire hazard when exposed to heat or flame; can react vigorously with oxidizing materials. Polymerizes explosively on exposure to acids or acid fumes. A storage hazard. When heated to decomposition it emits toxic fumes of NOx.
Safety data of Propylenei mine (75-55-8):
Hazard Codes: F;T+;N,T
F: Highly Flammable T: Toxic   
 N: Dangerous for the environment   T+: Very Toxic
Risk Statements: 45-11-26/27/28-41-51/53
45: May cause cancer 
11: Highly Flammable 
26/27/28: Very Toxic by inhalation, in contact with skin and if swallowed 
41: Risk of serious damage to eyes 
51/53: Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment
Safety Statements: 53-45-61
53: Avoid exposure - obtain special instruction before use 
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) 
61: Avoid release to the environment. Refer to special instructions safety data sheet  
RIDADR: 1921
RTECS: CM8050000
HazardClass: 3.1
PackingGroup: I

2-Methylaziridine Standards and Recommendations

OSHA PEL: TWA 2 ppm (skin)
ACGIH TLV: TWA 2 ppm (skin); Animal Carcinogen
DFG MAK: Animal Carcinogen, Suspected Human Carcinogen
DOT Classification:  3; Label: Flammable Liquid