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3,4-Dimethoxy-2-pyridinemethanol
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Name

3,4-Dimethoxy-2-pyridinemethanol

 EINECS N/A
CAS No. 72830-08-1 Density 1.171 g/cm3
PSA 51.58000 LogP 0.59110
Solubility N/A Melting Point N/A
Formula C8H11NO3 Boiling Point 275.516 °C at 760 mmHg
Molecular Weight 169.18 Flash Point 120.428 °C
Transport Information N/A Appearance N/A
Safety Risk Codes N/A
Molecular Structure Molecular Structure of 72830-08-1 (3,4-Dimethoxy-2-pyridinemethanol) Hazard Symbols IrritantXi
Synonyms

2-Hydroxymethyl-3,4-dimethoxypyridine;3,4-Dimethoxy-2-(hydroxymethyl)pyridine;

Article Data 10

3,4-Dimethoxy-2-pyridinemethanol Synthetic route

72830-07-0

3,4-dimethoxy-2-methylpyridine N-oxide

72830-08-1

2-hydroxymethyl-3,4-dimethoxypyridine

Conditions
ConditionsYield
With acetic anhydride for 4h; Reflux;91%
Stage #1: 3,4-dimethoxy-2-methylpyridine N-oxide With acetic anhydride at 90℃; for 2h;
Stage #2: With sodium hydroxide In water at 80℃; for 2h;		76%
Multi-step reaction with 2 steps
1: 4 h / 100 °C
2: 2 M NaOH / 1 h / 100 °C
View Scheme
Multi-step reaction with 2 steps
1: 2 h / 90 °C
2: 2 N aq. NaOH / 2 h / 80 °C
View Scheme
Multi-step reaction with 2 steps
1: AcOH / 120 °C
2: 2N aq. NaOH / methanol / 2 h / 25 °C
View Scheme
102625-99-0

2-acetoxymethyl-3,4-dimethoxypyridine

72830-08-1

2-hydroxymethyl-3,4-dimethoxypyridine

Conditions
ConditionsYield
With sodium hydroxide at 80℃; for 2h; Yield given;
With sodium hydroxide In methanol at 25℃; for 2h;
With sodium hydroxide at 100℃; for 1h;
With sodium hydroxide In Petroleum ether
With sodium hydroxide In Petroleum ether
118-71-8

Maltol

72830-08-1

2-hydroxymethyl-3,4-dimethoxypyridine

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 68 percent / K2CO3 / acetone / 19 h / Heating
2: 77 percent / conc. ammonia / 3 h / 110 °C
3: 85 percent / POCl3 / 10 h / Heating
4: NaOMe / 10 h / Heating
5: 98 percent / 84percent m-CPBA / CH2Cl2 / 4 h / Ambient temperature
6: 4 h / 100 °C
7: 2 M NaOH / 1 h / 100 °C
View Scheme
Multi-step reaction with 4 steps
1.1: ammonium hydroxide / 2 h / 40 °C
1.2: 10 h / 40 °C / Reflux
2.1: potassium hydroxide / water / 20 h / 10 - 20 °C
3.1: acetic acid; sodium tungstate; dihydrogen peroxide / 4 h / 40 - 95 °C
4.1: acetic anhydride / 4 h / Reflux
View Scheme
4780-14-7

3-methoxy-2-methyl-4-pyrone

72830-08-1

2-hydroxymethyl-3,4-dimethoxypyridine

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 77 percent / conc. ammonia / 3 h / 110 °C
2: 85 percent / POCl3 / 10 h / Heating
3: NaOMe / 10 h / Heating
4: 98 percent / 84percent m-CPBA / CH2Cl2 / 4 h / Ambient temperature
5: 4 h / 100 °C
6: 2 M NaOH / 1 h / 100 °C
View Scheme
76015-11-7

2-methyl-3-methoxy-4(1H)-pyridinone

72830-08-1

2-hydroxymethyl-3,4-dimethoxypyridine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 85 percent / POCl3 / 10 h / Heating
2: NaOMe / 10 h / Heating
3: 98 percent / 84percent m-CPBA / CH2Cl2 / 4 h / Ambient temperature
4: 4 h / 100 °C
5: 2 M NaOH / 1 h / 100 °C
View Scheme
Multi-step reaction with 5 steps
1: 96 percent / POCl3 / 18 h / 90 °C
2: 90 percent / 30percent aq. H2O2, AcOH / 24 h / 90 °C
3: 91 percent / NaOMe / 18 h
4: 2 h / 90 °C
5: 2 N aq. NaOH / 2 h / 80 °C
View Scheme
Multi-step reaction with 4 steps
1.1: trichlorophosphate / 18 h / 90 °C / Inert atmosphere
2.1: acetic acid; dihydrogen peroxide / water / 24 h / 90 °C
3.1: methanol / 16 h / 40 °C
4.1: acetic anhydride / 2 h / 90 °C
4.2: 2 h / 80 °C
View Scheme
107512-34-5

4-Chloro-3-methoxy-2-methyl-pyridine

72830-08-1

2-hydroxymethyl-3,4-dimethoxypyridine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: NaOMe / 10 h / Heating
2: 98 percent / 84percent m-CPBA / CH2Cl2 / 4 h / Ambient temperature
3: 4 h / 100 °C
4: 2 M NaOH / 1 h / 100 °C
View Scheme
Multi-step reaction with 4 steps
1: 90 percent / 30percent aq. H2O2, AcOH / 24 h / 90 °C
2: 91 percent / NaOMe / 18 h
3: 2 h / 90 °C
4: 2 N aq. NaOH / 2 h / 80 °C
View Scheme
Multi-step reaction with 3 steps
1.1: acetic acid; dihydrogen peroxide / water / 24 h / 90 °C
2.1: methanol / 16 h / 40 °C
3.1: acetic anhydride / 2 h / 90 °C
3.2: 2 h / 80 °C
View Scheme
107512-35-6

3,4-dimethoxy-2-methylpyridine

72830-08-1

2-hydroxymethyl-3,4-dimethoxypyridine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 98 percent / 84percent m-CPBA / CH2Cl2 / 4 h / Ambient temperature
2: 4 h / 100 °C
3: 2 M NaOH / 1 h / 100 °C
View Scheme
Multi-step reaction with 2 steps
1: acetic acid; sodium tungstate; dihydrogen peroxide / 4 h / 40 - 95 °C
2: acetic anhydride / 4 h / Reflux
View Scheme
15931-25-6

3-methoxy-2-methyl-4-nitropyridine 1-oxide

72830-08-1

2-hydroxymethyl-3,4-dimethoxypyridine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 88 percent / NaOMe / 16 h / 40 °C
2: 2 h / 90 °C
3: 2 N aq. NaOH / 2 h / 80 °C
View Scheme
35392-65-5

3-methoxy-2-methylpyridine 1-oxide

72830-08-1

2-hydroxymethyl-3,4-dimethoxypyridine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 58 percent / 98percent HNO3 / acetic acid / 33 h / 80 °C
2: 88 percent / NaOMe / 16 h / 40 °C
3: 2 h / 90 °C
4: 2 N aq. NaOH / 2 h / 80 °C
View Scheme
122307-41-9

4-chloro-3-methoxy-2-methylpyridine N-oxide

72830-08-1

2-hydroxymethyl-3,4-dimethoxypyridine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 91 percent / NaOMe / 18 h
2: 2 h / 90 °C
3: 2 N aq. NaOH / 2 h / 80 °C
View Scheme
Multi-step reaction with 2 steps
1.1: methanol / 16 h / 40 °C
2.1: acetic anhydride / 2 h / 90 °C
2.2: 2 h / 80 °C
View Scheme

3,4-Dimethoxy-2-pyridinemethanol Chemical Properties

Product Name: 3,4-Dimethoxy-2-pyridinemethanol
Molecular Structure:

Molecular Formula: C8H11NO3
Molecular Weight: 169.1778
Synonyms of 3,4-Dimethoxy-2-pyridinemethanol (CAS NO.72830-08-1): 4-Chloro-2-chloromethyl-3-methoxypyridine hydrochloride ; 4-Chloro-2-chloromethyl-3-methoxypyridine,hydrochloride salt ; 4-Chloro-3-methoxy-2-chloromethylpyridine hcl ; 4-Chloro-3-methoxy-2-chloromethyl pyridine hydrochloride ; 2-Hydroxymethyl-3,4-dimethoxypyridine
CAS NO: 72830-08-1
Product Categories: Pyridines, Pyrimidines, Purines and Pteredines ; Pyridines derivates ; API intermediates 
H bond acceptors: 4
H bond donors: 1
Freely Rotating Bonds: 4
Polar Surface Area: 51.58 Å2
Index of Refraction: 1.523
Molar Refractivity: 44.152 cm3
Molar Volume: 144.478 cm3
Surface Tension: 42.229 dyne/cm
Density: 1.171 g/cm3
Flash Point: 120.428 °C
Enthalpy of Vaporization: 54.292 kJ/mol
Boiling Point: 275.516 °C at 760 mmHg
Vapour Pressure of 3,4-Dimethoxy-2-pyridinemethanol (CAS NO.72830-08-1): 0.002 mmHg at 25°C

3,4-Dimethoxy-2-pyridinemethanol Safety Profile

Hazard Codes of 3,4-Dimethoxy-2-pyridinemethanol (CAS NO.72830-08-1): IrritantXi
Hazard Note: Irritant 

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