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CAS No.: | 72830-08-1 |
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Name: | 3,4-Dimethoxy-2-pyridinemethanol |
Article Data: | 10 |
Molecular Structure: | |
Formula: | C8H11NO3 |
Molecular Weight: | 169.18 |
Synonyms: | 2-Hydroxymethyl-3,4-dimethoxypyridine;3,4-Dimethoxy-2-(hydroxymethyl)pyridine; |
Density: | 1.171 g/cm3 |
Boiling Point: | 275.516 °C at 760 mmHg |
Flash Point: | 120.428 °C |
Hazard Symbols: | Xi |
PSA: | 51.58000 |
LogP: | 0.59110 |
3,4-dimethoxy-2-methylpyridine N-oxide
2-hydroxymethyl-3,4-dimethoxypyridine
Conditions | Yield |
---|---|
With acetic anhydride for 4h; Reflux; | 91% |
Stage #1: 3,4-dimethoxy-2-methylpyridine N-oxide With acetic anhydride at 90℃; for 2h; Stage #2: With sodium hydroxide In water at 80℃; for 2h; | 76% |
Multi-step reaction with 2 steps 1: 4 h / 100 °C 2: 2 M NaOH / 1 h / 100 °C View Scheme | |
Multi-step reaction with 2 steps 1: 2 h / 90 °C 2: 2 N aq. NaOH / 2 h / 80 °C View Scheme | |
Multi-step reaction with 2 steps 1: AcOH / 120 °C 2: 2N aq. NaOH / methanol / 2 h / 25 °C View Scheme |
2-acetoxymethyl-3,4-dimethoxypyridine
2-hydroxymethyl-3,4-dimethoxypyridine
Conditions | Yield |
---|---|
With sodium hydroxide at 80℃; for 2h; Yield given; | |
With sodium hydroxide In methanol at 25℃; for 2h; | |
With sodium hydroxide at 100℃; for 1h; | |
With sodium hydroxide In Petroleum ether | |
With sodium hydroxide In Petroleum ether |
Maltol
2-hydroxymethyl-3,4-dimethoxypyridine
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: 68 percent / K2CO3 / acetone / 19 h / Heating 2: 77 percent / conc. ammonia / 3 h / 110 °C 3: 85 percent / POCl3 / 10 h / Heating 4: NaOMe / 10 h / Heating 5: 98 percent / 84percent m-CPBA / CH2Cl2 / 4 h / Ambient temperature 6: 4 h / 100 °C 7: 2 M NaOH / 1 h / 100 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: ammonium hydroxide / 2 h / 40 °C 1.2: 10 h / 40 °C / Reflux 2.1: potassium hydroxide / water / 20 h / 10 - 20 °C 3.1: acetic acid; sodium tungstate; dihydrogen peroxide / 4 h / 40 - 95 °C 4.1: acetic anhydride / 4 h / Reflux View Scheme |
3-methoxy-2-methyl-4-pyrone
2-hydroxymethyl-3,4-dimethoxypyridine
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 77 percent / conc. ammonia / 3 h / 110 °C 2: 85 percent / POCl3 / 10 h / Heating 3: NaOMe / 10 h / Heating 4: 98 percent / 84percent m-CPBA / CH2Cl2 / 4 h / Ambient temperature 5: 4 h / 100 °C 6: 2 M NaOH / 1 h / 100 °C View Scheme |
2-methyl-3-methoxy-4(1H)-pyridinone
2-hydroxymethyl-3,4-dimethoxypyridine
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 85 percent / POCl3 / 10 h / Heating 2: NaOMe / 10 h / Heating 3: 98 percent / 84percent m-CPBA / CH2Cl2 / 4 h / Ambient temperature 4: 4 h / 100 °C 5: 2 M NaOH / 1 h / 100 °C View Scheme | |
Multi-step reaction with 5 steps 1: 96 percent / POCl3 / 18 h / 90 °C 2: 90 percent / 30percent aq. H2O2, AcOH / 24 h / 90 °C 3: 91 percent / NaOMe / 18 h 4: 2 h / 90 °C 5: 2 N aq. NaOH / 2 h / 80 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: trichlorophosphate / 18 h / 90 °C / Inert atmosphere 2.1: acetic acid; dihydrogen peroxide / water / 24 h / 90 °C 3.1: methanol / 16 h / 40 °C 4.1: acetic anhydride / 2 h / 90 °C 4.2: 2 h / 80 °C View Scheme |
4-Chloro-3-methoxy-2-methyl-pyridine
2-hydroxymethyl-3,4-dimethoxypyridine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: NaOMe / 10 h / Heating 2: 98 percent / 84percent m-CPBA / CH2Cl2 / 4 h / Ambient temperature 3: 4 h / 100 °C 4: 2 M NaOH / 1 h / 100 °C View Scheme | |
Multi-step reaction with 4 steps 1: 90 percent / 30percent aq. H2O2, AcOH / 24 h / 90 °C 2: 91 percent / NaOMe / 18 h 3: 2 h / 90 °C 4: 2 N aq. NaOH / 2 h / 80 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: acetic acid; dihydrogen peroxide / water / 24 h / 90 °C 2.1: methanol / 16 h / 40 °C 3.1: acetic anhydride / 2 h / 90 °C 3.2: 2 h / 80 °C View Scheme |
3,4-dimethoxy-2-methylpyridine
2-hydroxymethyl-3,4-dimethoxypyridine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 98 percent / 84percent m-CPBA / CH2Cl2 / 4 h / Ambient temperature 2: 4 h / 100 °C 3: 2 M NaOH / 1 h / 100 °C View Scheme | |
Multi-step reaction with 2 steps 1: acetic acid; sodium tungstate; dihydrogen peroxide / 4 h / 40 - 95 °C 2: acetic anhydride / 4 h / Reflux View Scheme |
3-methoxy-2-methyl-4-nitropyridine 1-oxide
2-hydroxymethyl-3,4-dimethoxypyridine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 88 percent / NaOMe / 16 h / 40 °C 2: 2 h / 90 °C 3: 2 N aq. NaOH / 2 h / 80 °C View Scheme |
3-methoxy-2-methylpyridine 1-oxide
2-hydroxymethyl-3,4-dimethoxypyridine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 58 percent / 98percent HNO3 / acetic acid / 33 h / 80 °C 2: 88 percent / NaOMe / 16 h / 40 °C 3: 2 h / 90 °C 4: 2 N aq. NaOH / 2 h / 80 °C View Scheme |
4-chloro-3-methoxy-2-methylpyridine N-oxide
2-hydroxymethyl-3,4-dimethoxypyridine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 91 percent / NaOMe / 18 h 2: 2 h / 90 °C 3: 2 N aq. NaOH / 2 h / 80 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: methanol / 16 h / 40 °C 2.1: acetic anhydride / 2 h / 90 °C 2.2: 2 h / 80 °C View Scheme |
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Product Name: 3,4-Dimethoxy-2-pyridinemethanol
Molecular Structure:
Molecular Formula: C8H11NO3
Molecular Weight: 169.1778
Synonyms of 3,4-Dimethoxy-2-pyridinemethanol (CAS NO.72830-08-1): 4-Chloro-2-chloromethyl-3-methoxypyridine hydrochloride ; 4-Chloro-2-chloromethyl-3-methoxypyridine,hydrochloride salt ; 4-Chloro-3-methoxy-2-chloromethylpyridine hcl ; 4-Chloro-3-methoxy-2-chloromethyl pyridine hydrochloride ; 2-Hydroxymethyl-3,4-dimethoxypyridine
CAS NO: 72830-08-1
Product Categories: Pyridines, Pyrimidines, Purines and Pteredines ; Pyridines derivates ; API intermediates
H bond acceptors: 4
H bond donors: 1
Freely Rotating Bonds: 4
Polar Surface Area: 51.58 Å2
Index of Refraction: 1.523
Molar Refractivity: 44.152 cm3
Molar Volume: 144.478 cm3
Surface Tension: 42.229 dyne/cm
Density: 1.171 g/cm3
Flash Point: 120.428 °C
Enthalpy of Vaporization: 54.292 kJ/mol
Boiling Point: 275.516 °C at 760 mmHg
Vapour Pressure of 3,4-Dimethoxy-2-pyridinemethanol (CAS NO.72830-08-1): 0.002 mmHg at 25°C
Hazard Codes of 3,4-Dimethoxy-2-pyridinemethanol (CAS NO.72830-08-1): Xi
Hazard Note: Irritant