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Cas Database |
| Name |
3,5-Dimethoxyaniline |
EINECS | 233-616-5 |
| CAS No. | 10272-07-8 | Density | 1.096 g/cm3 |
| PSA | 44.48000 | LogP | 1.86720 |
| Solubility | insoluble in water | Melting Point |
54-57 ºC |
| Formula | C8H11NO2 | Boiling Point | 178 ºC (20 mmHg) |
| Molecular Weight | 153.181 | Flash Point | 135 ºC |
| Transport Information | UN 2811 | Appearance | White crystal or Colorless liquid |
| Safety | 26-36-36/37/39-22 | Risk Codes | 22-36/37/38-20/21/22 |
| Molecular Structure |
|
Hazard Symbols |
 Xn, Xi
|
| Synonyms |
3,5-Dimethoxy-phenylamine;3,5-Dimethoxybenzeneamine;Benzenamine, 3,5-dimethoxy-;3，5-dimethoxy aniline;5-Aminoresorcinol dimethylether; |
Article Data | 36 |
3,5-Dimethoxyaniline Synthetic route
- 85862-68-6
1-azido-3,5-dimethoxybenzene
- 10272-07-8
3,5-Dimethoxyaniline
Conditions
| Conditions | Yield |
|---|---|
| With sodium tetrahydroborate; palladium In water for 1.5h; Inert atmosphere; | 99% |
| With sodium sulfide; water for 0.5h; Reflux; | 96% |
| With ammonium hydroxide at 90℃; for 0.5h; | 90% |
| With triethylamine; tris[tert-butyl]phosphonium tetrafluoroborate In tetrahydrofuran; water at 20℃; for 15h; Staudinger Azide Reduction; | 94 %Spectr. |
- 85657-94-9
N-(3,5-dimethoxyphenyl)-2,2,2-trifluoroacetamide
- 10272-07-8
3,5-Dimethoxyaniline
Conditions
| Conditions | Yield |
|---|---|
| With water; potassium carbonate In methanol for 20h; Ambient temperature; | 94% |
- 106018-88-6
2-Trimethylsilanyl-ethanesulfonic acid (3,5-dimethoxy-phenyl)-amide
- 10272-07-8
3,5-Dimethoxyaniline
Conditions
| Conditions | Yield |
|---|---|
| With cesium fluoride In N,N-dimethyl-formamide at 95℃; for 40h; | 93% |
- 7051-16-3
1-chloro-3,5-dimethoxybenzene
- 10272-07-8
3,5-Dimethoxyaniline
Conditions
| Conditions | Yield |
|---|---|
| With ammonium hydroxide; potassium phosphate In dimethyl sulfoxide at 80℃; UV-irradiation; | 93% |
| With ammonium hydroxide; potassium phosphate; copper(l) iodide; N1,N2-bis(5-methyl-[1,1'-biphenyl]-2-yl)oxalamide In water; dimethyl sulfoxide at 110℃; for 24h; Inert atmosphere; | 88% |
| With ammonium hydroxide; potassium phosphate; copper(l) iodide; N1,N2-bis(5-methyl-[1,1'-biphenyl]-2-yl)oxalamide In dimethyl sulfoxide at 120℃; for 24h; Inert atmosphere; Schlenk technique; | 88% |
- 79257-61-7
N-(3,5-dimethoxy-phenyl)-acetamide
- 10272-07-8
3,5-Dimethoxyaniline
Conditions
| Conditions | Yield |
|---|---|
| Stage #1: N-(3,5-dimethoxy-phenyl)-acetamide With Schwartz's reagent In tetrahydrofuran at 20℃; for 0.05h; Inert atmosphere; Stage #2: With water In tetrahydrofuran Inert atmosphere; chemoselective reaction; | 86% |
| With alkaline solution |
- 192182-54-0
3,5-dimethoxyphenylboronic acid
- 10272-07-8
3,5-Dimethoxyaniline
Conditions
| Conditions | Yield |
|---|---|
| With sodium hydroxide; hydroxylamine-O-sulfonic acid In acetonitrile at 20℃; for 16h; | 82% |
- 20469-65-2
1-bromo-3,5-dimethoxybenzene
- 10272-07-8
3,5-Dimethoxyaniline
Conditions
| Conditions | Yield |
|---|---|
| Stage #1: 1-bromo-3,5-dimethoxybenzene With magnesium In tetrahydrofuran Inert atmosphere; Stage #2: With C10H17NO In tetrahydrofuran; toluene at -78℃; for 2h; Inert atmosphere; Stage #3: With ammonium chloride In tetrahydrofuran; water; toluene Inert atmosphere; | 78% |
| With ammonium hydroxide; copper(l) iodide; N,N'-bis(3,5-dimethoxyphenyl)cyclopentane-1,1-dicarboxamide; caesium carbonate In dimethyl sulfoxide at 90℃; for 24h; Inert atmosphere; Sealed tube; | 68% |
| With ammonia; sodium; ferric nitrate |
- 25245-27-6
1-iodo-3,5-dimethoxybenzene
- 10272-07-8
3,5-Dimethoxyaniline
Conditions
| Conditions | Yield |
|---|---|
| With ammonium hydroxide; copper(l) iodide; N,N'-bis(3,5-dimethoxyphenyl)cyclopentane-1,1-dicarboxamide; caesium carbonate In dimethyl sulfoxide at 20℃; for 24h; Inert atmosphere; Sealed tube; | 75% |
- 500-99-2
3,5-dimethoxyphenol
- 10272-07-8
3,5-Dimethoxyaniline
Conditions
| Conditions | Yield |
|---|---|
| Stage #1: 3,5-dimethoxyphenol With Nonafluorobutanesulfonyl fluoride; tris(trimethylsilyl)amine; potassium hexamethylsilazane In tetrahydrofuran at 60℃; for 5h; Schlenk technique; Inert atmosphere; Stage #2: With hydrogenchloride In water at 20℃; for 0.0833333h; pH=3 - 4; Reagent/catalyst; Solvent; | 75% |
- 1132-21-4
3,5-dimethoxybenzoic acid
- 10272-07-8
3,5-Dimethoxyaniline
Conditions
| Conditions | Yield |
|---|---|
| Stage #1: 3,5-dimethoxybenzoic acid With diphenylphosphoranyl azide; triethylamine In toluene at 80℃; Stage #2: With sodium hydroxide In tetrahydrofuran; toluene at 20℃; for 2h; | 43% |
| Stage #1: 3,5-dimethoxybenzoic acid With diphenylphosphoranyl azide; triethylamine In toluene at 80℃; Stage #2: With sodium hydroxide In tetrahydrofuran for 2h; | 43% |
3,5-Dimethoxyaniline Chemical Properties
Formula：C8H11NO2
Molecular Weight：153.18
Appearance：Beige crystals
Solubility in water：Soluble
Melting Point：66 – 68
Boiling Point：303
3,5-Dimethoxyaniline`s Synonyms：BENZENAMINE, 3,5-DIMETHOXY-;3,5-DIMETHOXYANILINE;3,5-DIMETHOXYPHENYLAMINE;5-AMINORESORCINOL DIMETHYL ESTER;5-AMINORESORCINOL DIMETHYL ETHER;AKOS 91392;3,5-dimethoxy-benzenamin;3,5-dimethoxy-Benzenamine
Molecular Structure:
Molecular Weight：153.18
Appearance：Beige crystals
Solubility in water：Soluble
Melting Point：66 – 68
Boiling Point：303
3,5-Dimethoxyaniline`s Synonyms：BENZENAMINE, 3,5-DIMETHOXY-;3,5-DIMETHOXYANILINE;3,5-DIMETHOXYPHENYLAMINE;5-AMINORESORCINOL DIMETHYL ESTER;5-AMINORESORCINOL DIMETHYL ETHER;AKOS 91392;3,5-dimethoxy-benzenamin;3,5-dimethoxy-Benzenamine
Molecular Structure:
3,5-Dimethoxyaniline Toxicity Data With Reference
3,5-Dimethoxyaniline may cause gastrointestinal irritation with nausea, vomiting and diarrhea. respiratory tract irritation and skin or eyes irritation. The toxicological properties of this substance have not been fully investigated
3,5-Dimethoxyaniline Consensus Reports
Stability:Stable under normal temperatures and pressures
First Aid Measures:
Ingestion: If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation: Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical ai
Skin: Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Storage：Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Handling：Wash thoroughly after handling. Use only in a well ventilated area. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
First Aid Measures:
Ingestion: If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation: Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical ai
Skin: Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Storage：Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Handling：Wash thoroughly after handling. Use only in a well ventilated area. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
3,5-Dimethoxyaniline Safety Profile
Hazard Codes: Xn, Xi
Risk Statements: 22-36/37/38-20/21/22
Safety Statements: 26-36-36/37/39-22
WGK Germany: 3
Hazard Note: Irritant
Risk Phrases:
R 20/21/22 Harmful by inhalation, in contact with skin and if swallowed.
R 36/37/38 Irritating to eyes, respiratory system and skin.
Safety Phrases:
S 22 Do not breathe dust.
S 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36/37/39 Wear suitable protective clothing, gloves and eye/face protection.
Risk Statements: 22-36/37/38-20/21/22
Safety Statements: 26-36-36/37/39-22
WGK Germany: 3
Hazard Note: Irritant
Risk Phrases:
R 20/21/22 Harmful by inhalation, in contact with skin and if swallowed.
R 36/37/38 Irritating to eyes, respiratory system and skin.
Safety Phrases:
S 22 Do not breathe dust.
S 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36/37/39 Wear suitable protective clothing, gloves and eye/face protection.
3,5-Dimethoxyaniline Specification
Flash Point: 142
Fire Fighting: Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire, use water fog, dry chemical, carbon dioxide, or regular foam.
Personal Protection: Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Fire Fighting: Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire, use water fog, dry chemical, carbon dioxide, or regular foam.
Personal Protection: Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
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