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3-Fluoro-4-iodoaniline

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Name

3-Fluoro-4-iodoaniline

EINECS 690-811-1
CAS No. 656-66-6 Density 2.009 g/cm3
PSA 26.02000 LogP 2.59370
Solubility Slightly soluble in water (228.3 mg/L at 25°C). Melting Point 76-77 °C
Formula C6H5FIN Boiling Point 273.722 °C at 760 mmHg
Molecular Weight 237.015 Flash Point 119.343 °C
Transport Information N/A Appearance N/A
Safety Risk Codes N/A
Molecular Structure Molecular Structure of 656-66-6 (3-Fluoro-4-iodoaniline) Hazard Symbols N/A
Synonyms

Aniline,3-fluoro-4-iodo- (7CI,8CI);

Article Data 6

3-Fluoro-4-iodoaniline Synthetic route

372-19-0

meta-fluoroaniline

A

656-66-6

3-fluoro-4-iodoaniline

B

5-fluoro-2,4-diiodoaniline

C

5-fluoro-2-iodoaniline

Conditions
ConditionsYield
With iodine; sodium hydrogencarbonate In water at 20℃; for 0.5h;A 74%
B 6%
C 4%
372-19-0

meta-fluoroaniline

656-66-6

3-fluoro-4-iodoaniline

Conditions
ConditionsYield
With iron(III) chloride; N-iodo-succinimide; 1-butyl-3-methylimidazolium trifluoromethanesulfonimide at 20℃; for 2h; Inert atmosphere;62%
With iodine; sodium hydrogencarbonate In water at 20℃; for 3h;62%
With sodium periodate; sulfuric acid; iodine In acetic acid at 80℃; for 4h;50%
With iodine; mercury(II) oxide In ethanol
With iodine; sodium hydrogencarbonate In water at 20℃;
656-66-6

3-fluoro-4-iodoaniline

1066-54-2

trimethylsilylacetylene

3-fluoro-4-[(trimethylsilyl)ethynyl]aniline

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide In triethylamine at 20℃; for 46h; Sonogashira Cross-Coupling; Schlenk technique; Inert atmosphere;97%
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In tetrahydrofuran at 20℃; for 21h; Sonogashira Cross-Coupling; Inert atmosphere;
656-66-6

3-fluoro-4-iodoaniline

2996-92-1

phenyl trimethylsiloxane

2-fluoro-1,1'-biphenyl-4-amine

Conditions
ConditionsYield
With sodium hydroxide In ethylene glycol at 100℃; for 2h; Hiyama Coupling;92%
1191-95-3

cyclobutanone

656-66-6

3-fluoro-4-iodoaniline

N-cyclobutyl-3-fluoro-4-iodoaniline

Conditions
ConditionsYield
With sodium tris(acetoxy)borohydride; acetic acid In dichloromethane at 20℃; for 2h;70%
656-66-6

3-fluoro-4-iodoaniline

67-64-1

acetone

3-fluoro-4-iodo-N-isopropylaniline

Conditions
ConditionsYield
With sodium tris(acetoxy)borohydride; acetic acid In dichloromethane at 20℃; for 2h;70%
613-90-1

benzoyl cyanide

656-66-6

3-fluoro-4-iodoaniline

N-(4-cyano-3-fluorophenyl)benzamide

Conditions
ConditionsYield
With copper(I) oxide In dimethyl sulfoxide at 130℃; for 10h;65%
656-66-6

3-fluoro-4-iodoaniline

320592-15-2

1,4-anhydro-3,5-di-O-benzyl-2-deoxy-L-erythro-pent-1-enitol

320592-21-0

4-(5-((benzyloxy)methyl)-4-(benzyloxy)-2,5-dihydro-β-L-furan-2-yl)-3-fluoroaniline

Conditions
ConditionsYield
With triphenyl-arsane; triethylamine; palladium diacetate In acetonitrile at 70℃; for 24h;57%
656-66-6

3-fluoro-4-iodoaniline

115-19-5

2-methyl-but-3-yn-2-ol

4-(4-amino-2-fluorophenyl)-2-methylbut-3-yn-2-ol

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In acetonitrile at 20 - 60℃; for 1.5h; Sonogashira Cross-Coupling; Inert atmosphere;54%
656-66-6

3-fluoro-4-iodoaniline

127099-85-8, 780722-26-1

N-Cyanoguanidine

1-carbamimidamido-N-(3-fluoro-4-iodophenyl)methanimidamide hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In water at 100℃; for 18h; Inert atmosphere; Sealed tube;54%

3-Fluoro-4-iodoaniline Chemical Properties

Molecular Structure of 3-Fluoro-4-iodoaniline(656-66-6):

IUPAC Name:3-fluoro-4-iodoaniline
Molecular Formula:C6H5FIN
Molecular Weight:237.013473 g/mol
Density:2.008 g/cm3
Flash Point:119.3 °C
Enthalpy of Vaporization:51.21 kJ/mol
Boiling Point:273.7 °C at 760 mmHg
Vapour Pressure:0.00564 mmHg at 25 °C
Water Solubility:228.3 mg/L at 25 °C
Synonyms of 3-Fluoro-4-iodoaniline(656-66-6):
3-FLUORO-4-IODOANILINE;3-Fluoro-4-iodobenzenamine
Categories of 3-Fluoro-4-iodoaniline(656-66-6):
Aniline;Anilines, Amides & Amines;Fluorine Compounds;Iodine Compounds

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