1. Introduction of 3-Hydroxyphenylacetic acid
3-Hydroxyphenylacetic acid, with the CAS registry number 621-37-4, is also known as 3-Hydroxyphenylacetic acid. It belongs to the product categories of Aromatic Phenylacetic Acids and Derivatives; Aromatics; Carbonyl Compounds; Carboxylic Acids. What's more, its IUPAC name is 2-(3-hydroxyphenyl)acetic acid.

2. Properties of 3-Hydroxyphenylacetic acid
(1)ACD/LogP: 0.77; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -0.58; (4)ACD/LogD (pH 7.4): -2.35; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 2.78; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 3; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 3; (12)Polar Surface Area: 35.53 Å²; (13)Index of Refraction: 1.596; (14)Molar Refractivity: 39.24 cm³; (15)Molar Volume: 115.3 cm³; (16)Surface Tension: 59.8 dyne/cm; (17)Density: 1.319 g/cm³; (18)Flash Point: 179.1 °C; (19)Enthalpy of Vaporization: 62.63 kJ/mol; (20)Boiling Point: 349 °C at 760 mmHg; (21)Vapour Pressure: 1.81E-05 mmHg at 25°C.

3. Structure Descriptors of 3-Hydroxyphenylacetic acid
(1)Canonical SMILES: C1=CC(=CC(=C1)O)CC(=O)O
(2)InChI: InChI=1S/C8H8O3/c9-7-3-1-2-6(4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)
(3)InChIKey: FVMDYYGIDFPZAX-UHFFFAOYSA-N  

4. Safety Information of 3-Hydroxyphenylacetic acid
Hazard Symbols:Xi
Risk Codes:
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Description:
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36:Wear suitable protective clothing. 

5. Preparation of 3-Hydroxyphenylacetic acid
3-Hydroxyphenylacetic acid can be prepared by (3-hydroxy-phenyl)-acetic acid and 3-bromo-propene by heating. This reaction will need reagent NaH and solvent tetrahydrofuran. The reaction time is 15 hours. The yield is about 98%.

6. Use of 3-Hydroxyphenylacetic acid
3-Hydroxyphenylacetic acid can be used to produce ethyl 3-hydroxyphenylacetate by heating. It will need reagent H₂SO₄ with reaction time of 7 hours. The yield is about 94%.

7. Other details of 3-Hydroxyphenylacetic acid
When you are using this chemical, please be cautious about it as the following:
3-Hydroxyphenylacetic acid is irritating to eyes, respiratory system and skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. You need wear suitable protective clothing.