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3-Methoxy-2-Nitropyridine

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Name

3-Methoxy-2-Nitropyridine

EINECS -0
CAS No. 20265-37-6 Density 1.3 g/cm3
PSA 67.94000 LogP 1.52160
Solubility Soluble in ethanol and water Melting Point 73-76 °C(lit.)
Formula C6H6N2O3 Boiling Point 311.8 °C at 760 mmHg
Molecular Weight 154.125 Flash Point 142.4 °C
Transport Information N/A Appearance Yellow crystalline powder
Safety 26-36 Risk Codes 36/37/38
Molecular Structure Molecular Structure of 20265-37-6 (3-Methoxy-2-nitropyridine) Hazard Symbols IrritantXi
Synonyms

2-Nitro-3-methoxypyridine;3-(Methyloxy)-2-nitropyridine;ZINC02559368;AC1LBDP2;AC1Q4FFX;561703_ALDRICH;

Article Data 13

3-Methoxy-2-Nitropyridine Specification

The 3-Methoxy-2-Nitropyridine with CAS registry number of 20265-37-6 is also known as 2-Nitro-3-methoxypyridine. The IUPAC name and product name are the same. It belongs to product categories of Pyridine; Pyridines, Pyrimidines, Purines and Pteredines; Pyridines; Pyridines derivates; C6; Heterocyclic Building Blocks. In addition, the formula is C6H6N2O3 and the molecular weight is 154.12. This chemical is a yellow crystalline powder and should be stored in cool and dry place.

Physical properties about 3-Methoxy-2-Nitropyridine are: (1)ACD/LogP: 0.74; (2)ACD/LogD (pH 5.5): 0.74; (3)ACD/LogD (pH 7.4): 0.74; (4)ACD/BCF (pH 5.5): 2.13; (5)ACD/BCF (pH 7.4): 2.13; (6)ACD/KOC (pH 5.5): 59.84; (7)ACD/KOC (pH 7.4): 59.84; (8)#H bond acceptors: 5; (9)#Freely Rotating Bonds: 2; (10)Index of Refraction: 1.546; (11)Molar Refractivity: 37.56 cm3; (12)Molar Volume: 118.5 cm3; (13)Surface Tension: 49 dyne/cm; (14)Density: 1.3 g/cm3; (15)Flash Point: 142.4 °C; (16)Enthalpy of Vaporization: 53.07 kJ/mol; (17)Boiling Point: 311.8 °C at 760 mmHg; (18)Vapour Pressure: 0.00101 mmHg at 25 °C.

Preparation of 3-Methoxy-2-Nitropyridine: it is prepared by reaction of 2-nitro-pyridin-3-ol with iodomethane. The reaction needs reagent KOH and solvent dimethylsulfoxide for 20 minutes. The yield is about 90.9%.

3-Methoxy-2-Nitropyridine is prepared by reaction of 2-nitro-pyridin-3-ol with iodomethane.

Uses of 3-Methoxy-2-Nitropyridine: it is used to produce benzyl-(2-nitro-pyridin-3-yl)-amine by reaction with benzylamine. The reaction occurs with reagent CHCl3 at the temperature of 110 °C for 2 hours. The yield is about 90%. Besides, it is used as pharmaceutical intermediate.

3-Methoxy-2-Nitropyridine is used to produce benzyl-(2-nitro-pyridin-3-yl)-amine by reaction with benzylamine.

When you are using this chemical, please be cautious about it. As a chemical, it is irritating to eyes, respiratory system and skin. During using it, wear suitable protective clothing. If contact with eyes accidently, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
1. Canonical SMILES: COC1=C(N=CC=C1)[N+](=O)[O-]
2. InChI: InChI=1S/C6H6N2O3/c1-11-5-3-2-4-7-6(5)8(9)10/h2-4H,1H3
3. InChIKey: LSXHCFSGOBFNDX-UHFFFAOYSA-N

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