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Name |
3-Methoxy-2-Nitropyridine |
EINECS | -0 |
CAS No. | 20265-37-6 | Density | 1.3 g/cm3 |
PSA | 67.94000 | LogP | 1.52160 |
Solubility | Soluble in ethanol and water | Melting Point |
73-76 °C(lit.) |
Formula | C6H6N2O3 | Boiling Point | 311.8 °C at 760 mmHg |
Molecular Weight | 154.125 | Flash Point | 142.4 °C |
Transport Information | N/A | Appearance | Yellow crystalline powder |
Safety | 26-36 | Risk Codes | 36/37/38 |
Molecular Structure | Hazard Symbols | Xi | |
Synonyms |
2-Nitro-3-methoxypyridine;3-(Methyloxy)-2-nitropyridine;ZINC02559368;AC1LBDP2;AC1Q4FFX;561703_ALDRICH; |
Article Data | 13 |
The 3-Methoxy-2-Nitropyridine with CAS registry number of 20265-37-6 is also known as 2-Nitro-3-methoxypyridine. The IUPAC name and product name are the same. It belongs to product categories of Pyridine; Pyridines, Pyrimidines, Purines and Pteredines; Pyridines; Pyridines derivates; C6; Heterocyclic Building Blocks. In addition, the formula is C6H6N2O3 and the molecular weight is 154.12. This chemical is a yellow crystalline powder and should be stored in cool and dry place.
Physical properties about 3-Methoxy-2-Nitropyridine are: (1)ACD/LogP: 0.74; (2)ACD/LogD (pH 5.5): 0.74; (3)ACD/LogD (pH 7.4): 0.74; (4)ACD/BCF (pH 5.5): 2.13; (5)ACD/BCF (pH 7.4): 2.13; (6)ACD/KOC (pH 5.5): 59.84; (7)ACD/KOC (pH 7.4): 59.84; (8)#H bond acceptors: 5; (9)#Freely Rotating Bonds: 2; (10)Index of Refraction: 1.546; (11)Molar Refractivity: 37.56 cm3; (12)Molar Volume: 118.5 cm3; (13)Surface Tension: 49 dyne/cm; (14)Density: 1.3 g/cm3; (15)Flash Point: 142.4 °C; (16)Enthalpy of Vaporization: 53.07 kJ/mol; (17)Boiling Point: 311.8 °C at 760 mmHg; (18)Vapour Pressure: 0.00101 mmHg at 25 °C.
Preparation of 3-Methoxy-2-Nitropyridine: it is prepared by reaction of 2-nitro-pyridin-3-ol with iodomethane. The reaction needs reagent KOH and solvent dimethylsulfoxide for 20 minutes. The yield is about 90.9%.
Uses of 3-Methoxy-2-Nitropyridine: it is used to produce benzyl-(2-nitro-pyridin-3-yl)-amine by reaction with benzylamine. The reaction occurs with reagent CHCl3 at the temperature of 110 °C for 2 hours. The yield is about 90%. Besides, it is used as pharmaceutical intermediate.
When you are using this chemical, please be cautious about it. As a chemical, it is irritating to eyes, respiratory system and skin. During using it, wear suitable protective clothing. If contact with eyes accidently, rinse immediately with plenty of water and seek medical advice.
You can still convert the following datas into molecular structure:
1. Canonical SMILES: COC1=C(N=CC=C1)[N+](=O)[O-]
2. InChI: InChI=1S/C6H6N2O3/c1-11-5-3-2-4-7-6(5)8(9)10/h2-4H,1H3
3. InChIKey: LSXHCFSGOBFNDX-UHFFFAOYSA-N