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Name	4-(Trifluoromethyl)pyridine	EINECS	-0
CAS No.	3796-24-5	Density	1.266 g/cm³
PSA	12.89000	LogP	2.10040
Solubility	N/A	Melting Point	N/A
Formula	C₆H₄F₃N	Boiling Point	141.7 °C at 760 mmHg
Molecular Weight	147.1	Flash Point	39.5 °C
Transport Information	UN 1993 3/PG 2	Appearance	colorless liquid
Safety	16-26-36-37/60	Risk Codes	11-36/37/38
Molecular Structure		Hazard Symbols	F,Xi
Synonyms	Pyridine, 4-trifluoromethyl-;	Article Data	31

4-(Trifluoromethyl)pyridine Synthetic route

: 22253-59-4
1-oxido-4-(trifluoromethyl)pyridin-1-ium

: 3796-24-5
4-trifluoromethylpyridine

Conditions

Conditions	Yield
With phenylsilane; 3-Methyl-1-phenyl-2-phospholene 1-oxide In acetonitrile for 16h; Irradiation; chemoselective reaction;	93%

: 15854-87-2
4-iodopyridine

: trifluoromethanesulfonic acid diphenyl(trifluoromethyl)sulfonium salt

: 3796-24-5
4-trifluoromethylpyridine

Conditions

Conditions	Yield
With copper In N,N-dimethyl-formamide at 60℃; for 11h;	91%

: 55-22-1
pyridine-4-carboxylic acid

: 3796-24-5
4-trifluoromethylpyridine

Conditions

Conditions	Yield
With F6Mo at 170 - 190℃; for 40h;	80%

: 339539-96-7
3-hydroxy-3-trifluoromethyl-1,5-pentanedialdehyde

: 3796-24-5
4-trifluoromethylpyridine

Conditions

Conditions	Yield
With ammonia In methanol for 24h; Heating;	70%
With ammonium hydroxide In methanol for 24h; Reflux;	70%

: 81565-18-6
2-chloro-4-trifluoromethyl pyridine

: 3796-24-5
4-trifluoromethylpyridine

Conditions

Conditions	Yield
With propylamine In tetrahydrofuran at 20℃; for 15h; Reagent/catalyst; Solvent; Inert atmosphere; Irradiation; Sealed tube;	68%
With triethylamine; Lumogen F Orange 240 In N,N-dimethyl-formamide at 40℃; for 16h; Irradiation;	91 %Chromat.
With ZnSe/CdS core/shell QDs; N-ethyl-N,N-diisopropylamine In hexane at 25℃; for 48h; Irradiation; Inert atmosphere;	23 %Chromat.

: 15854-87-2
4-iodopyridine

: 81290-20-2
(trifluoromethyl)trimethylsilane

: 3796-24-5
4-trifluoromethylpyridine

Conditions

Conditions	Yield
With potassium fluoride; copper(l) iodide In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide at 25℃; for 6h;	25%
With C13H27CuN2O(1+) In N,N-dimethyl-formamide at 25℃; for 112h;	99 %Spectr.

: 110-86-1
pyridine

: 75-63-8
Bromotrifluoromethane

A: 3796-24-5
4-trifluoromethylpyridine

B: 3796-23-4
3-(trifluoromethyl)pyridine

C: 368-48-9
2-(trifluoromethyl)pyridine

Conditions

Conditions	Yield
With dipotassium hydrogenphosphate; sodium dithionite In water at 65℃; under 2250.2 - 3750.3 Torr; for 2h;	A 5% B 1% C 4%

: 110-86-1
pyridine

: 2314-97-8
iodotrifluoromethane

A: 3796-24-5
4-trifluoromethylpyridine

B: 3796-23-4
3-(trifluoromethyl)pyridine

C: 20857-47-0
3,5-bis(trifluoromethyl)pyridine

D: 455-00-5
2,6-bis-(trifluoromethyl)pyridine

E: 368-48-9
2-(trifluoromethyl)pyridine

Conditions

Conditions	Yield
for 96h; Product distribution; Irradiation; The yields, the kind of products depend on the time of the irrad. and/or the temp., and the mol. ratio. Other trifluorometh. agents investigated;

...Expand

: 36610-32-9
4-hydroxy-4-trifluoromethyl-1,6-heptadiene

: 3796-24-5
4-trifluoromethylpyridine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 90 percent / O3 / CH2Cl2; methanol / 24 h / -78 °C 2: 70 percent / NH3 / methanol / 24 h / Heating View Scheme
Multi-step reaction with 2 steps 1.1: ozone / dichloromethane; methanol / -78 °C 1.2: 2 h / 20 °C 2.1: ammonium hydroxide / methanol / 24 h / Reflux View Scheme

: 110-86-1
pyridine

: 887144-97-0
Togni's reagent

A: 3796-24-5
4-trifluoromethylpyridine

B: 3796-23-4
3-(trifluoromethyl)pyridine

C: 368-48-9
2-(trifluoromethyl)pyridine

Conditions

Conditions	Yield
In acetonitrile at 80℃; for 96h; Inert atmosphere;	A 3 %Spectr. B 16 %Spectr. C 17 %Spectr.

4-(Trifluoromethyl)pyridine Chemical Properties

Molecular Structure:

Molecular Formula: C₆H₄F₃N
Molecular Weight: 147.0979
IUPAC Name: 4-(Trifluoromethyl)pyridine
Synonyms of 4-(Trifluoromethyl)pyridine (CAS NO.3796-24-5): Pyridine, 4-trifluoromethyl-
CAS NO: 3796-24-5
Classification Code: Pyridine series ; Pyridine ; Pyridines ; C6 ; Heterocyclic Building Blocks
Index of Refraction: 1.418
Molar Refractivity: 29.32 cm³
Molar Volume: 116.1 cm³
Surface Tension: 24.5 dyne/cm
Density: 1.266 g/cm³
Flash Point: 39.5 °C
Enthalpy of Vaporization: 36.32 kJ/mol
Boiling Point: 141.7 °C at 760 mmHg
Vapour Pressure: 7.24 mmHg at 25°C

4-(Trifluoromethyl)pyridine Uses

4-(Trifluoromethyl)pyridine (CAS NO.3796-24-5) is commonly used as pharmaceutical intermediate.

4-(Trifluoromethyl)pyridine Safety Profile

Hazard Codes of 4-(Trifluoromethyl)pyridine (CAS NO.3796-24-5): F, Irritant Xi
Risk Statements: 11-36/37/38
R11: Highly flammable.
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 16-26-36-37/60
S16: Keep away from sources of ignition.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36: Wear suitable protective clothing.
S37: Wear suitable gloves.
S60: This material and its container must be disposed of as hazardous waste.
RIDADR: UN 1993 3/PG 2
WGK Germany: 3
Hazard Note: Irritant/Flammable
HazardClass: 3
PackingGroup: II

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