Welcome to LookChem.com Sign In|Join Free
  • or
Home > Products >  > 

4-BIPHENYLACETIC ACID
Related Products

Hot Products

Basic Information Post buying leads Suppliers Cas Database
Name

4-BIPHENYLACETIC ACID

 EINECS 227-233-2
CAS No. 5728-52-9 Density 1.165 g/cm3
PSA 37.30000 LogP 2.98070
Solubility 39.27mg/L(25 oC) Melting Point 159-160 °C(lit.)
Formula C14H12O2 Boiling Point 389.8 °C at 760 mmHg
Molecular Weight 212.248 Flash Point 286.6 °C
Transport Information UN 2811 6.1/PG 3 Appearance Off-white powder
Safety 26-36/37/39-45-37/39-28A-26/36/3745/60-20-36 Risk Codes 23/25-36/37/38-25-36/37/38/63-20/21/22
Molecular Structure Molecular Structure of 5728-52-9 (4-Biphenylacetic acid) Hazard Symbols ToxicT, HarmfulXn
Synonyms

4-Biphenylaceticacid (8CI);Acetic acid, (4-biphenylyl)- (6CI,7CI);([1,1'-Biphenyl]-4-yl)acetic acid;2-(Biphenyl-4-yl)acetic acid;4-Biphenylylaceticacid;4-Carboxymethylbiphenyl;4-Phenylphenylacetic acid;BPAA;Cl 83544;L 141;Seltouch;Traxam;p-Biphenylacetic acid;p-Biphenylylacetic acid;

Article Data 93

4-BIPHENYLACETIC ACID Synthetic route

98-80-6

phenylboronic acid

1878-68-8

2-(4-bromophenyl)-acetic acid

5728-52-9

(4-biphenylyl)acetic acid

Conditions
ConditionsYield
With sodium carbonate; Pd-complex on fluorous reversed silica gel In water at 80℃; for 16h; Suzuki reaction;100%
With carbon-doped cobalt; C118H94N4O7P8; palladium diacetate; sodium carbonate In tetrahydrofuran; water at 20 - 60℃; for 14h; Suzuki Coupling; Inert atmosphere;100%
With palladium diacetate; potassium carbonate In water; toluene at 65℃; for 20h; Solvent; Suzuki-Miyaura Coupling;100%
59793-29-2

methyl 2-(1,1'-biphenyl-4-yl)acetate

5728-52-9

(4-biphenylyl)acetic acid

Conditions
ConditionsYield
With methanol; potassium hydroxide for 10h; Reflux;99%
With water; sodium hydroxide at 70℃; for 4h;75.5%
With sodium hydroxide In methanol for 4h; Ambient temperature; Yield given;
With water; sodium hydroxide at 20℃; for 3h;2.56 g
31603-77-7

4-biphenylacetonitrile

5728-52-9

(4-biphenylyl)acetic acid

Conditions
ConditionsYield
With water; potassium hydroxide In ethylene glycol at 120℃; for 16h;97.6%
With hydrogenchloride
With water; sodium hydroxide for 4h; Time; Reflux;
With sodium hydroxide In water; butan-1-ol at 100℃; for 8h; Temperature;
143-66-8

sodium tetraphenyl borate

1878-68-8

2-(4-bromophenyl)-acetic acid

5728-52-9

(4-biphenylyl)acetic acid

Conditions
ConditionsYield
With sodium carbonate; palladium on activated charcoal In water for 1h; Suzuki reaction; Heating;96%
1878-66-6

4-chlorophenylacetic Acid

potassium phenyltrifluoborate

5728-52-9

(4-biphenylyl)acetic acid

Conditions
ConditionsYield
With choline chloride; palladium diacetate; sodium carbonate; glycerol at 100℃; for 5h; Suzuki-Miyaura Coupling;95%
With C16H16Cl2N2O4Pd2; tetrabutylammomium bromide; potassium carbonate In water at 100℃; under 749.884 Torr; for 0.25h; Microwave irradiation; Darkness; Inert atmosphere;86%
14062-23-8

4-biphenylylacetic acid ethyl ester

5728-52-9

(4-biphenylyl)acetic acid

Conditions
ConditionsYield
Stage #1: 4-biphenylylacetic acid ethyl ester With potassium hydroxide In water for 0.5h; Reflux;
Stage #2: With hydrogenchloride In water		94%
With potassium hydroxide In 1,4-dioxane; water for 18h; Reflux;76%
3418-30-2

2-Chlormethyl-2--<1.3>dioxolan

5728-52-9

(4-biphenylyl)acetic acid

Conditions
ConditionsYield
With copper(l) iodide; zinc diacetate at 155℃; for 1.5h;92.6%

tert-butyl 4-biphenylacetylenyl ether

5728-52-9

(4-biphenylyl)acetic acid

Conditions
ConditionsYield
With water; triethylamine In toluene at 75℃; for 12h; Inert atmosphere;92%
5428-57-9

2-biphenyl-4-yl-1-morpholin-4-yl-ethanethione

5728-52-9

(4-biphenylyl)acetic acid

Conditions
ConditionsYield
With sodium hydroxide for 0.0166667h; microwave irradiation;90%
With potassium hydroxide 1.) EtOH, reflux; 2.) 100 deg C, 2 h;79.7%
With sodium hydroxide In methanol; water for 8h; Reflux; Large scale;78.2%

C14H9O3(1-)*Na(1+)

5728-52-9

(4-biphenylyl)acetic acid

Conditions
ConditionsYield
Stage #1: C14H9O3(1-)*Na(1+) With hydrazine hydrate; sodium hydroxide In water at 80 - 100℃; for 17h;
Stage #2: With hydrogenchloride In water pH=3; Temperature;		87.4%

4-BIPHENYLACETIC ACID Chemical Properties

Name ：4-Biphenylacetic acid
Synonyms ：BIPHENYL-4-ACETIC ACID;FELBINAC;CI 83544;4-PHENYLPHENYLACETIC ACID;4-CARBOXYMETHYLBIPHENYL;4-BIPHENYLACETIC ACID;[1,1'-BIPHENYL]-4-ACETIC ACID;P-BIPHENYLACETIC ACID
 
Molecular Structure ： 
 
Molecular Formula ：C14H12O2
Molecular Weight ：212.25
CAS Registry Number ：5728-52-9
Melting point ：156-160 oC
EINECS ：227-233-2 
The compound 4-biphenylacetic acid is known and its preparation described in the literature, F. Blicke, et al., J. Am. Chem. Soc., 65, 1725 (1943). U.S. Pat. No. 3,784,704 also discloses the preparation of 4-biphenylacetic acid, and its usein producing long lasting amelioration of pain in warm-blooded animals. French Pat. No. 7,166M, patented Feb. 23, 1970, reports that 4-biphenylacetic acid possesses anti-inflammatory, antipyretic and analgesic activity.
  

4-BIPHENYLACETIC ACID Uses

4-Biphenylacetic acid can be useful, as an antithrombotic agent, in the treatment of well known thrombotic conditions resulting from platelet aggregation. 4-Biphenylacetic acid can be useful in reducing transient ischemic attacks of the brain and possibly the heart. 4-Biphenylacetic acid may also be useful extrinsically in preventing the clotting of shed and/or stored blood and it iscontemplated that its use as a platelet inhibitor extends both in vivo and in vitro platelet aggregation inhibition. 4-Biphenylacetic acid may be merely added to blood in vitro to prevent or inhibit platelet aggregation.

4-BIPHENYLACETIC ACID Toxicity Data With Reference

1.   

orl-rat LD50:410 mg/kg

   KSRNAM    Kiso to Rinsho. Clinical Report. 20 (1986),2107.
2.   

ipr-rat LD50:495 mg/kg

   KSRNAM    Kiso to Rinsho. Clinical Report. 20 (1986),2107.
3.   

scu-rat LD50:148 mg/kg

   KSRNAM    Kiso to Rinsho. Clinical Report. 20 (1986),2107.
4.   

orl-mus LD50:675 mg/kg

   KSRNAM    Kiso to Rinsho. Clinical Report. 20 (1986),2107.
5.   

ipr-mus LD50:508 mg/kg

   KSRNAM    Kiso to Rinsho. Clinical Report. 20 (1986),2107.
6.   

scu-mus LD50:730 mg/kg

   KSRNAM    Kiso to Rinsho. Clinical Report. 20 (1986),2107.
7.   

scu-dog LD50:320 mg/kg

   KSRNAM    Kiso to Rinsho. Clinical Report. 20 (1986),2107.
8.   

scu-rbt LD50:1280 mg/kg

   KSRNAM    Kiso to Rinsho. Clinical Report. 20 (1986),2107.

4-BIPHENYLACETIC ACID Safety Profile

Poison by subcutaneous route. Moderately toxic by ingestion and intraperitoneal routes. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits acrid smoke and fumes.
T: Toxic  
R25 ：Toxic if swallowed.
R36/37/38 : Irritating to eyes, respiratory system and skin.
S26 ：In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S28 ：After contact with skin, wash immediately with plenty of soap-suds.
S36/37 : Wear suitable protective clothing and gloves.
S45 In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)

 

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 5728-52-9