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4-Hydroxy-3,5-dimethoxycinnamic acid

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Name

4-Hydroxy-3,5-dimethoxycinnamic acid

EINECS 208-487-3
CAS No. 530-59-6 Density 1.307 g/cm3
PSA 75.99000 LogP 1.50720
Solubility slightly soluble in water Melting Point 203-205 °C (dec.)(lit.)
Formula C11H12O5 Boiling Point 403.4 °C at 760 mmHg
Molecular Weight 224.213 Flash Point 158.6 °C
Transport Information N/A Appearance yellow-brown crystalline powder
Safety 26-36-37/39 Risk Codes 36/37/38
Molecular Structure Molecular Structure of 530-59-6 (4-Hydroxy-3,5-dimethoxycinnamic acid) Hazard Symbols IrritantXi
Synonyms

Sinapic acid;3,5-Dimethoxy-4-hydroxycinnamic acid;Sinapinic acid;

Article Data 57

4-Hydroxy-3,5-dimethoxycinnamic acid Synthetic route

C19H30O6

530-59-6

trans-3,5-dimethoxy-4-hydroxycinnamic acid

Conditions
ConditionsYield
With potassium tert-butylate In isopropyl alcohol at 120℃; for 24h;94%
141-82-2

malonic acid

134-96-3

syringic aldehyde

530-59-6

trans-3,5-dimethoxy-4-hydroxycinnamic acid

Conditions
ConditionsYield
With aniline In pyridine at 60℃; Darkness;85%
Stage #1: malonic acid; syringic aldehyde With piperazine; pyridine; p-toluidine In toluene at 80℃; for 3h;
Stage #2: With potassium carbonate In water; toluene at 20℃; for 0.166667h;
83.7%
With piperidine; pyridine
85364-71-2

3-methyl-4-nitro-5-<2-(3,5-dimethoxy-4-hydroxyphenyl)ethenyl>isoxazole

530-59-6

trans-3,5-dimethoxy-4-hydroxycinnamic acid

Conditions
ConditionsYield
With sodium hydroxide for 2h; Heating;72.9%
110233-74-4

ethyl-(4'-acetoxy-3',5'-dimethoxyphenyl)-prop-2-enoate

530-59-6

trans-3,5-dimethoxy-4-hydroxycinnamic acid

Conditions
ConditionsYield
With potassium hydroxide In water Heating;
131189-50-9

alatanin 1

A

47845-44-3

cyanidin 3-O-gentiobioside

B

530-59-6

trans-3,5-dimethoxy-4-hydroxycinnamic acid

Conditions
ConditionsYield
With hydrogenchloride at 60℃; for 24h;

O-sinapoylcholine

530-59-6

trans-3,5-dimethoxy-4-hydroxycinnamic acid

Conditions
ConditionsYield
With sodium hydroxide Heating;

quercetin 3-<6-sinapyl-β-D-glucopyranosyl(1->2)-β-D-glucopyranosyl(1->2)-β-D-glucopyranoside>

A

530-59-6

trans-3,5-dimethoxy-4-hydroxycinnamic acid

B

38681-85-5

5,7-dihydroxy-3-[β-D-glucopyranosyl-(1->2)-β-D-glucopyranosyl-(1->2)-β-D-glucopyranosyl]-2-(3,4-dihydroxyphenyl)-4H-1-benzopyran-4-one

Conditions
ConditionsYield
With sodium hydroxide In sodium hydroxide for 24h; Product distribution; Ambient temperature; other reagent;
trimethyl-<2-(4-hydroxy-3.5-dimethoxy-trans-cinnamoyloxy)-ethyl>-ammonium iodide

trimethyl-<2-(4-hydroxy-3.5-dimethoxy-trans-cinnamoyloxy)-ethyl>-ammonium iodide

530-59-6

trans-3,5-dimethoxy-4-hydroxycinnamic acid

Conditions
ConditionsYield
With potassium hydroxide

6'''-sinapoylsaponarin

A

530-59-6

trans-3,5-dimethoxy-4-hydroxycinnamic acid

B

saponarin

Conditions
ConditionsYield
With sodium hydroxide In methanol; water at 60℃; for 4h;

4-Hydroxy-3,5-dimethoxycinnamic acid Chemical Properties

IUPAC Name:(E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoic acid
Molecular Formula:C11H12O5
Molecular Weight:224.209980 g/mol
Appearance:yellow to yellow-beige crystalline powder
Melting Point:203-205 °C (dec.)(lit.)
Density:1.307 g/cm3
Flash Point:158.6 °C
Enthalpy of Vaporization:69.04 kJ/mol
Boiling Point:403.4 °C at 760 mmHg
Vapour Pressure:3.12E-07 mmHg at 25 °C
Water Solubility:7082 mg/L at 25 °C
EINECS:208-487-3
Synonyms of 4-Hydroxy-3,5-dimethoxycinnamic acid(530-59-6):
(2E)-3-(4-Hydroxy-3,5-dimethoxyphenyl)-2-propenoic acid;2-Propenoic acid, 3-(4-hydroxy-3,5-dimethoxyphenyl)-;3,5-dimethoxy-4-hydroxycinnamicacid(sinapinicacid);3,5-dimethoxy-4-hydroxycinnamicacid,predominantlytransisomer;trans-3,5-Dimethoxy-4-hydroxycinnamic acid;4-HYDROXY-3,5-DIMETHOXYCINNAMIC ACID;3,5-DIMETHOXY-4-HYDROXY-TRANS-CINNAMIC ACID;3,5-DIMETHOXY-4-HYDROXYCINNAMIC ACID
Categories of 4-Hydroxy-3,5-dimethoxycinnamic acid(530-59-6):
Aromatic Cinnamic Acids, Esters and Derivatives;Analytical Chemistry;Mass Spectrometry;Matrix Materials (MALDI-TOF-MS)

4-Hydroxy-3,5-dimethoxycinnamic acid Safety Profile

Safety Information of 4-Hydroxy-3,5-dimethoxycinnamic acid(530-59-6):
Hazard Codes:Xi
Risk Statements:36/37/38
36/37/38:Irritating to eyes, respiratory system and skin
Safety Statements:26-36-37/39
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36:Wear suitable protective clothing
37/39:Wear suitable gloves and eye/face protection
WGK Germany:3
Hazard Note:Irritant

4-Hydroxy-3,5-dimethoxycinnamic acid Specification

First Aid Measures of 4-Hydroxy-3,5-dimethoxycinnamic acid(530-59-6):
Eyes:Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:Get medical aid. Wash mouth out with water.
Inhalation:Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.

Storage of 4-Hydroxy-3,5-dimethoxycinnamic acid(530-59-6):
Store in a cool, dry place. Store in a tightly closed container.

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