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Name |
4-Iodotoluene |
EINECS | 210-841-7 |
CAS No. | 624-31-7 | Density | 1.706 g/cm3 |
PSA | 0.00000 | LogP | 2.59960 |
Solubility | insoluble in water | Melting Point |
33-36 °C |
Formula | C7H7I | Boiling Point | 211.5 °C at 760 mmHg |
Molecular Weight | 218.037 | Flash Point | 86.3 °C |
Transport Information | N/A | Appearance | white to light yellow crystalline low melting mass |
Safety | 24/25-26 | Risk Codes | 36/37/38 |
Molecular Structure | Hazard Symbols | Xi | |
Synonyms |
Toluene,p-iodo- (7CI,8CI);1-Iodo-4-methylbenzene;1-Methyl-4-iodobenzene;4-Iodomethylbenzene; |
Article Data | 235 |
3,3-diethyl-1-(4-methylphenyl)-1-triazene
4-tolyl iodide
Conditions | Yield |
---|---|
With cation exchange resin BioRad AG 50W-X12 (H+); sodium iodide In acetonitrile at 75℃; Product distribution; further solvent: THF, DMSO; | 99% |
With sulfonic acid resin (H+ form, Bio-Rad AG 50W-12); sodium iodide In acetonitrile at 75℃; for 0.133333h; | 90% |
With chloro-trimethyl-silane; sodium iodide In acetonitrile at 60℃; for 0.0833333h; | 75% |
Conditions | Yield |
---|---|
With potassium iodide In water at 25℃; for 0.0833333h; Solvent; Sandmeyer Reaction; | 99% |
With iodine; potassium iodide In dimethyl sulfoxide at 15℃; | |
With trimethylsilyl iodide; 3-butyl-1-methyl-1H-imidazol-3-ium hexafluorophosphate at 65℃; for 2h; | 98 % Chromat. |
With diiodomethane; tetrabutylammonium perchlorate In methanol; N,N-dimethyl-formamide at 20℃; for 3h; Sandmeyer Reaction; Electrochemical reaction; | 71 %Chromat. |
With trimethylsilyl iodide at 60 - 70℃; Inert atmosphere; Ionic liquid; |
Conditions | Yield |
---|---|
With potassium ferrate(VI); iodine In hexane for 2.33333h; Reflux; regioselective reaction; | 95% |
With N-iodosaccharine at 20℃; Ionic liquid; Darkness; regioselective reaction; | 92% |
With sodium dodecyl-sulfate; sodium iodide; Ce(OH)3OOH at 20℃; for 2h; | 87% |
Conditions | Yield |
---|---|
Stage #1: p-toluidine With potassium sulfite; phosphoric acid In water at 6 - 18℃; for 0.25h; Stage #2: With sodium iodate In water at 35℃; Temperature; | 93% |
Stage #1: p-toluidine With sodium nitrite Stage #2: With potassium iodide | 91% |
Stage #1: p-toluidine With toluene-4-sulfonic acid In water at 20℃; Stage #2: With potassium iodide In water at 20℃; for 1.25h; | 91% |
Conditions | Yield |
---|---|
With copper(I) oxide; L-proline; potassium iodide In ethanol at 110℃; for 30h; Catalytic behavior; Reagent/catalyst; Time; Schlenk technique; Inert atmosphere; Sealed tube; | 93% |
With copper(l) iodide; pyrographite In neat (no solvent) at 150℃; for 36h; | 90% |
With copper(l) iodide; trans-N,N'-dimethylcyclohexane-1,2-diamine; sodium iodide In acetonitrile at 100℃; for 1h; Buchwald's halogen exchange reaction; Inert atmosphere; Microwave irradiation; | 90% |
4-tolyl iodide
Conditions | Yield |
---|---|
With chloroamine-T; sodium iodide In tetrahydrofuran; water at 20℃; for 0.166667h; | 91% |
4-tolyl iodide
Conditions | Yield |
---|---|
With tetra-(n-butyl)ammonium iodide In acetonitrile at 20℃; for 0.75h; Product distribution; Further Variations:; various reagent ratios; Substitution; | 90% |
With tetra-(n-butyl)ammonium iodide In acetonitrile at 20℃; for 0.75h; Substitution; | 82% |
Conditions | Yield |
---|---|
With sodium nitrite In acetonitrile at 80℃; for 0.5h; Reagent/catalyst; Temperature; Sealed tube; | 87% |
With copper(I) oxide; ammonium hydroxide; oxygen; potassium iodide In water at 25℃; for 24h; | 83% |
With iodine; potassium carbonate In acetonitrile at 80℃; for 10h; Solvent; Reagent/catalyst; Temperature; Inert atmosphere; Schlenk technique; Sealed tube; | 81% |
Conditions | Yield |
---|---|
With sodium carbonate In water at 80℃; for 2h; | A 86% B 196 mg |
bis(4-methylphenyl)iodonium trifluoromethanesulfonate
isopropylamine
N-(4-methylphenyl)cyanamide
A
4-tolyl iodide
Conditions | Yield |
---|---|
With [2,2]bipyridinyl; potassium carbonate; copper(l) chloride In toluene at 80℃; for 2h; Inert atmosphere; | A 76% B 24% C 85% |
IUPAC Name: 1-Iodo-4-methylbenzene
Synonyms of 4-Iodotoluene (CAS NO.624-31-7): 1-Methyl-4-iodobenzene ; p-Iodotoluene ; p-Methyliodobenzene ; p-Tolyl iodide
CAS NO: 624-31-7
Molecular Formula: C7H7I
Molecular Weight: 109.13
Molecular Structure:
EINECS: 210-841-7
H bond acceptors: 0
H bond donors: 0
Freely Rotating Bonds: 0
Polar Surface Area: 0 Å2
Index of Refraction: 1.604
Molar Refractivity: 43.98 cm3
Molar Volume: 127.7 cm3
Surface Tension: 39.5 dyne/cm
Density: 1.706 g/cm3
Flash Point: 86.3 °C
Enthalpy of Vaporization: 42.95 kJ/mol
Boiling Point: 211.5 °C at 760 mmHg
Vapour Pressure: 0.264 mmHg at 25°C
Melting point: 33-36°C
Water solubility: insoluble
Sensitive: Light Sensitive
Appearance: white to light yellow crystalline
SMILES: Ic1ccc(cc1)C
InChI: InChI=1/C7H7I/c1-6-2-4-7(8)5-3-6/h2-5H,1H3
InChIKey: UDHAWRUAECEBHC-UHFFFAOYAY
Std. InChI: InChI=1S/C7H7I/c1-6-2-4-7(8)5-3-6/h2-5H,1H3
Std. InChIKey: UDHAWRUAECEBHC-UHFFFAOYSA-N
Product Categories of 4-Iodotoluene (CAS NO.624-31-7): Aromatic Hydrocarbons (substituted) & Derivatives;Halogen toluene;Iodine Compounds;Pharmaceutical Intermediate
4-Iodotoluene (CAS NO.624-31-7) is mainly used for bio-pharmaceutical.
The Hazard Codes: Xi
The Risk Statements information:
36/37/38: Irritating to eyes, respiratory system and skin
The Safety Statements information:
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
24/25: Avoid contact with skin and eyes
WGK Germany: 3
TSCA: T
Hazard Note: Irritant
Explodes when heated above 200°C. Upon decomposition it emits toxic fumes of I−. See also IODIDES.
General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media: In case of fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.
Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.
Storage: Store in a cool, dry place. Keep container closed when not in use.