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Name	4-Piperidinemethanol	EINECS	-0
CAS No.	6457-49-4	Density	0.951 g/cm³
PSA	32.26000	LogP	0.30710
Solubility	Soluble in water	Melting Point	55-59 °C(lit.)
Formula	C₆H₁₃NO	Boiling Point	198.2 °C at 760 mmHg
Molecular Weight	115.175	Flash Point	92.3 °C
Transport Information	UN 3263 8/PG 2	Appearance	white to off-white crystalline powder, chunks
Safety	26-27-36/37/39-45	Risk Codes	34-22
Molecular Structure		Hazard Symbols	C, Xi
Synonyms	(4-Piperidinyl)methanol;(4-Piperidyl)methanol;4-(Hydroxymethyl)piperidine;4-Piperidine-1-methanol;	Article Data	45

4-Piperidinemethanol Synthetic route

: 1126-09-6
4-carbethoxypiperidine

: 6457-49-4
4-piperidinemethanol

Conditions

Conditions	Yield
Stage #1: 4-carbethoxypiperidine With lithium aluminium tetrahydride In tetrahydrofuran at 20℃; Stage #2: With sodium hydroxide; water In tetrahydrofuran at 20℃; for 0.5h;	100%
Stage #1: 4-carbethoxypiperidine With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃; Stage #2: With ethanol; water In tetrahydrofuran at 0℃;	100%
With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃;	92%

: 2971-79-1
isonipecotic acid methyl ester

: 6457-49-4
4-piperidinemethanol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran at 20℃; for 20h; Inert atmosphere;	90%

: 498-94-2
isonipecotic acid

: 6457-49-4
4-piperidinemethanol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran at 21℃; for 24h;	80%
Multi-step reaction with 2 steps 1: ethanolic HCl 2: ethanol; sodium View Scheme
With sodium hydroxide; LiAlH4 In tetrahydrofuran; water

: 383865-57-4
4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl-amine

A: 6457-49-4
4-piperidinemethanol

B: 4-(hydroxymethyl)-N-(4-methoxy-7-morpholinobenzo[d]thiazol-2-yl)piperidine-1-carboxamide

Conditions

Conditions	Yield
	A n/a B 31%

: 622387-50-2
4-(4-hydroxy-piperidine-1-sulfonyl)-tetrahydro-pyran-4-carboxylic acid tert-butyl ester

: 4282-40-0
1-Iodoheptane

: 6457-49-4
4-piperidinemethanol

Conditions

Conditions	Yield
Stage #1: 4-(4-hydroxy-piperidine-1-sulfonyl)-tetrahydro-pyran-4-carboxylic acid tert-butyl ester With sodium hydride In tetrahydrofuran at 20℃; for 0.5h; Stage #2: 1-Iodoheptane In tetrahydrofuran at 50℃; for 26h;	20%

: 399580-55-3
4-(methoxymethyl)piperidine

: 6457-49-4
4-piperidinemethanol

Conditions

Conditions	Yield
With water; hydrogen bromide

: 586-95-8
pyridine-4-methanol

: 6457-49-4
4-piperidinemethanol

Conditions

Conditions	Yield
With sulfuric acid; water; platinum at 65℃; Hydrogenation;
With hydrogenchloride; PtO2 In ethanol; water

: 1570-45-2
isonicotinic acid ethylester

A: 6457-49-4
4-piperidinemethanol

B: 1126-09-6
4-carbethoxypiperidine

Conditions

Conditions	Yield
With sodium; butan-1-ol

: 1570-45-2
isonicotinic acid ethylester

: 71-36-3
butan-1-ol

sodium: sodium

A: 6457-49-4
4-piperidinemethanol

B: 1126-09-6
4-carbethoxypiperidine

: 101990-69-6
(2,6-dichloropyridin-4-yl)methanol

: 6457-49-4
4-piperidinemethanol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: methanol. KOH-solution; palladium/barium carbonate / Hydrogenation 2: sulfuric acid; water; platinum / 65 °C / Hydrogenation View Scheme

4-Piperidinemethanol Chemical Properties

Molecular Structure of 4-Piperidinemethanol (CAS NO.6457-49-4):

IUPAC Name: Piperidin-4-ylmethanol
Canonical SMILES: C1CNCCC1CO
InChI: InChI=1S/C6H13NO/c8-5-6-1-3-7-4-2-6/h6-8H,1-5H2
InChIKey: XBXHCBLBYQEYTI-UHFFFAOYSA-N
Molecular Weight: 115.17352 [g/mol]
Molecular Formula: C₆H₁₃NO
XLogP3-AA: -0.1
H-Bond Donor: 2
H-Bond Acceptor: 2
Appearance: white to off-white crystalline powder, chunks
Melting Point: 55-59 °C(lit.)
Index of Refraction: 1.451
Molar Refractivity: 32.63 cm³
Molar Volume: 121 cm³
Surface Tension: 34.8 dyne/cm
Density: 0.951 g/cm³
Flash Point: 92.3 °C
Enthalpy of Vaporization: 50.54 kJ/mol
Boiling Point: 198.2 °C at 760 mmHg
Vapour Pressure: 0.0924 mmHg at 25°C
Sensitive: Hygroscopic
Product Categories: Alcohols and Derivatives; Amines and Anilines; pharmacetical; PiperidineDerivative; Hydroxymethyl's; Pyrans, Piperidines &Piperazines; Piperidine; Alkohols; Pyrans, Piperidines & Piperazines

4-Piperidinemethanol Uses

4-Piperidinemethanol can be used in organic synthesis.

4-Piperidinemethanol Safety Profile

Safety Information of 4-Piperidinemethanol (CAS NO.6457-49-4):
Hazard Codes: Corrosive C, Irritant Xi
Risk Statements: 34-22
R34:Causes burns.
R22:Harmful if swallowed.
Safety Statements: 26-27-36/37/39-45
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S27:Take off immediately all contaminated clothing.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 3263 8/PG 2
WGK Germany: 3
Hazard Note: Irritant/Hygroscopic
HazardClass: 8
PackingGroup: III

4-Piperidinemethanol Specification

4-Piperidinemethanol (CAS NO.6457-49-4), its Synonyms are 4-Piperidylmethanol ; 4-(Hydroxymethyl)piperidine ; 4-Piperidine-1-methanol .

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