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Cas Database |
| Name |
4-Tolyl ether |
EINECS | 216-423-0 |
| CAS No. | 1579-40-4 | Density | 1.029 g/cm3 |
| PSA | 9.23000 | LogP | 4.09570 |
| Solubility | N/A | Melting Point |
47-49 °C(lit.) |
| Formula | C14H14O | Boiling Point | 285.5 °C at 760 mmHg |
| Molecular Weight | 198.265 | Flash Point | 121.3 °C |
| Transport Information | UN 3077 9/PG 3 | Appearance | N/A |
| Safety | 26-36-61 | Risk Codes | 36/37/38-50/53 |
| Molecular Structure |
|
Hazard Symbols |
 Xi,  N
|
| Synonyms |
p-Tolylether (6CI,7CI,8CI);4,4'-Dimethyldiphenyl ether;Bis(4-methylphenyl) ether;Di-p-Tolyl ether;p-(p-Tolyloxy)toluene; |
Article Data | 59 |
4-Tolyl ether Synthetic route
| Conditions | Yield |
|---|---|
| With copper diacetate; water; triethylamine In dichloromethane; acetonitrile at 25℃; for 6h; | 97% |
| Multi-step reaction with 2 steps 1: 85 percent / H2O2 / H2O / 20 °C 2: molecular sieves 4 Angstroem; Cu(OAc)2; Et3N / CH2Cl2 / 20 °C View Scheme |
| Conditions | Yield |
|---|---|
| With aluminum oxide; potassium fluoride; copper(l) iodide In toluene at 100 - 110℃; for 22h; | 95% |
| With caesium carbonate In N,N-dimethyl-formamide at 130℃; for 24h; Ullmann Condensation; | 90% |
| With potassium phosphate; copper(l) iodide; tetrabutylammomium bromide In N,N-dimethyl-formamide for 22h; Ullmann coupling; Heating; | 87% |
- 106-44-5
p-cresol
- 1428064-59-8
2,4-dimethoxyphenyl(4-methylphenyl)iodonium tosylate
- 1579-40-4
1,1'-oxybis(4-methyl-benzene)
| Conditions | Yield |
|---|---|
| With potassium carbonate In acetonitrile at 50℃; for 6h; regioselective reaction; | 93% |
| Conditions | Yield |
|---|---|
| With potassium phosphate In N,N-dimethyl-formamide at 80℃; for 4h; Ullmann Condensation; | 90% |
| With potassium carbonate In water for 2.41667h; Ullmann Condensation; Reflux; Green chemistry; | 87% |
| With potassium phosphate; 2-((o-toluidino)methyl)phenol; copper(l) chloride In acetonitrile at 81℃; for 24h; Catalytic behavior; Ullmann Condensation; Schlenk technique; Inert atmosphere; | 85% |
| Conditions | Yield |
|---|---|
| With potassium phosphate; copper(l) iodide; 2,2,6,6-tetramethylheptane-3,5-dione; water In ethanol at 130℃; for 30h; Inert atmosphere; Sealed tube; chemoselective reaction; | 90% |
| Multi-step reaction with 2 steps 1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.5 h / 20 °C 2: sodium hydroxide / dichloromethane / 22 h / 20 °C View Scheme | |
| Multi-step reaction with 2 steps 1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.5 h / 20 °C 2: sodium hydroxide; piperidine / dichloromethane / 14 h / 40 °C View Scheme |
| Conditions | Yield |
|---|---|
| With potassium tert-butylate In tetrahydrofuran at 40℃; | 88% |
- 106-38-7
para-bromotoluene
- 62790-85-6
tert-Butyl(dimethyl)-(4-methylphenoxy)silane
- 1579-40-4
1,1'-oxybis(4-methyl-benzene)
| Conditions | Yield |
|---|---|
| With copper(l) iodide; caesium carbonate In N,N-dimethyl-formamide at 100℃; for 8h; | 81% |
| Conditions | Yield |
|---|---|
| With potassium phosphate; tri-tert-butyl phosphine; tris-(dibenzylideneacetone)dipalladium(0) In 1,4-dioxane at 100℃; for 20h; | 78% |
| Conditions | Yield |
|---|---|
| With potassium phosphate; tri-tert-butyl phosphine; tris-(dibenzylideneacetone)dipalladium(0) In 1,4-dioxane at 100℃; for 20h; | 72% |
- 110-85-0
piperazine
- 106-38-7
para-bromotoluene
A
- 106-44-5
p-cresol
B
- 3367-48-4
1,4-bis(4-methylphenyl)piperazine
C
- 108-88-3
toluene
D
- 1579-40-4
1,1'-oxybis(4-methyl-benzene)
| Conditions | Yield |
|---|---|
| With Adipic acid; N'-phenyloxalyl bishydrazide; copper diacetate; sodium acetate; cetyltrimethylammonim bromide; 2,5-hexanedione; potassium hydroxide In water at 100℃; for 3h; Inert atmosphere; | A 21 %Chromat. B 68% C 13 %Chromat. D 11 %Chromat. |
4-Tolyl ether Chemical Properties
MF: C14H14O
MW: 198.260 g/mol
EINECS: 216-423-0
Flash Point: 121.3 °C
Index of Refraction: 1.56
Melting Point: 47-49 °C(lit.)
Enthalpy of Vaporization: 50.35 kJ/mol
Boiling Point: 285.5 °C at 760 mmHg
Vapour Pressure: 0.0048 mmHg at 25°C
IUPAC Name: 1-methyl-4-(4-methylphenoxy)benzene
Density of P-(p-Tolyloxy)toluene (1579-40-4): 1.029 g/cm3
Synonyms: 1,1’-Oxybis(4-methyl-benzen ; 1,1’-Oxybis(4-methylbenzene) ; 1,1’-Oxybis[4-methyl-benzen ; Benzene, 1,1'-Oxybis*4-methyl- ; Benzene, 1,1'-Oxybis[4-methyl- ; Bis(4-methylphenyl) ether ; Bis(4-methylphenyl)ether ; P-(p-Tolyloxy)toluene
Product Categories: Ethers ; Organic Building Blocks ; Oxygen Compounds
Following is the molecular structure of P-(p-Tolyloxy)toluene (1579-40-4):
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4-Tolyl ether Toxicity Data With Reference
| 1. | skn-rbt 500 mg/24H SEV | NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) OTS0545443 . | ||
| 2. | orl-rat LDLo:2250 mg/kg | NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) OTS0537676 . | ||
| 3. | ihl-rat LC :>184 ppm/4H | NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) OTS0537676 . | ||
| 4. | skn-rbt LDLo:7940 mg/kg | NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) OTS0545443 . |
4-Tolyl ether Consensus Reports
Reported in EPA TSCA Inventory.
4-Tolyl ether Safety Profile
Moderately toxic by ingestion and inhalation. Low toxicity by skin contact. A severe skin irritant. When heated to decomposition it emits acrid smoke and irritating vapors.
Safety Information of P-(p-Tolyloxy)toluene (1579-40-4):
Hazard Codes: Xi,N
Xi: Irritant .gif){kind=small}
N: Dangerous for the environment .gif){kind=small}
Risk Statements: 36/37/38-50/53
36/37/38: Irritating to eyes, respiratory system and skin
50/53: Very Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment
Safety Statements: 26-36-61
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
61: Avoid release to the environment. Refer to special instructions safety data sheet
RIDADR: UN 3077 9/PG 3
WGK Germany: 2
RTECS: DA6625000
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