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Cas Database |
| Name |
4-methoxybenzylamine |
EINECS | 219-247-2 |
| CAS No. | 2393-23-9 | Density | 1.028 g/cm3 |
| PSA | 35.25000 | LogP | 1.85420 |
| Solubility | It is highly soluble in water. | Melting Point |
-10 °C |
| Formula | C8H11NO | Boiling Point | 236.499 °C at 760 mmHg |
| Molecular Weight | 137.181 | Flash Point | 98.8 °C |
| Transport Information | UN 2735 8/PG 2 | Appearance | clear colorless to slightly yellow liquid |
| Safety | 26-36/37/39-45-27 | Risk Codes | 34-37-22 |
| Molecular Structure |
|
Hazard Symbols |
 C
|
| Synonyms |
Benzylamine,p-methoxy- (6CI,7CI,8CI);(4-Methoxyphenyl)methanamine;1-(4-Methoxyphenyl)methanamine;1-Aminomethyl-4-methoxybenzene;4-Methoxybenzenemethanamine;4-Methoxyphenylmethylamine;Anisylamine;Para-methoxybenzylamine;p-Methoxybenzylamine; |
Article Data | 204 |
4-methoxybenzylamine Synthetic route
| Conditions | Yield |
|---|---|
| With hydrogen; aluminum oxide; silica gel; nickel In methanol; ammonia at 120℃; under 7600 Torr; for 6h; | 100% |
| With palladium 10% on activated carbon; hydrogen In methanol at 20℃; for 24h; | 100% |
| With [bis(2-methylallyl)cycloocta-1,5-diene]ruthenium(II); potassium tert-butylate; hydrogen bromide; hydrogen; 2-((di-iso-propylphosphino)methyl)-1-methyl-1H-imidazole In tetrahydrofuran; water; acetone; toluene at 20℃; under 37503.8 Torr; for 5.5h; Inert atmosphere; Schlenk technique; Autoclave; | 98% |
- 21244-24-6
2-[(4-methoxyphenyl)methyl]-1H-isoindole-1,3(2H)-dione
- 2393-23-9
4-methoxy-benzylamine
| Conditions | Yield |
|---|---|
| With hydrazine hydrate In tetrahydrofuran for 16h; Reflux; | 99% |
| With hydrazine hydrate In 1,4-dioxane at 110℃; Gabriel Amine Synthesis; Inert atmosphere; | 90% |
| With sodium hydroxide und anschliessend mit verd.Salzsaeure; |
- 3717-21-3, 3717-22-4, 140461-28-5, 140461-29-6, 3235-04-9
p-methoxyl benzaldoxime
- 2393-23-9
4-methoxy-benzylamine
| Conditions | Yield |
|---|---|
| With sodium tetrahydroborate at 20℃; for 0.0333333h; neat (no solvent, solid phase); | 98% |
| With sodium hydrogensulfate monohydrate; molybdenum(V) chloride; sodium cyanoborohydride In ethanol for 1.1h; Reflux; | 95% |
| With ammonium formate; zinc In methanol for 0.05h; Heating; | 92% |
- 2393-23-9
4-methoxy-benzylamine
| Conditions | Yield |
|---|---|
| With 2-hydroxyethanethiol In N,N-dimethyl-formamide at 20℃; for 1h; | 98% |
| Conditions | Yield |
|---|---|
| With nickel(II) tetrafluoroborate hexahydrate; ammonia; hydrogen; bis(2-diphenylphosphinoethyl)phenylphosphine In 2,2,2-trifluoroethanol at 100℃; for 24h; chemoselective reaction; | 97% |
| With ammonium hydroxide; hydrogen In ethanol at 130℃; under 7500.75 Torr; for 12h; Autoclave; | 93.4% |
| With ammonia; hydrogen In methanol at 30℃; for 15h; Autoclave; | 92% |
- 171414-16-7
N-(4-methoxybenzyl)-2-nitro-N-(prop-2-yn-1-yl)benzenesulfonamide
- 2393-23-9
4-methoxy-benzylamine
| Conditions | Yield |
|---|---|
| With polystyrene-thiophenol; caesium carbonate; triphenylphosphine In tetrahydrofuran at 20℃; for 24h; | 96% |
| With potassium carbonate; thiophenol In acetonitrile at 50℃; | 93% |
| With caesium carbonate; thiophenol In N,N-dimethyl-formamide at 20℃; for 0.5h; | 88% |
| Conditions | Yield |
|---|---|
| With copper(ll) sulfate pentahydrate; ammonium hydroxide In PEG1000-DIL; methyl cyclohexane at 60℃; for 3h; | 96% |
| With ammonia at 25℃; Kinetics; Activation energy; Temperature; Reagent/catalyst; | |
| Multi-step reaction with 2 steps 1: N,N-dimethyl-formamide / 18 h / Reflux 2: hydrazine hydrate / tetrahydrofuran / 16 h / Reflux View Scheme |
- 70978-37-9
1-(azidomethyl)-4-methoxybenzene
- 2393-23-9
4-methoxy-benzylamine
| Conditions | Yield |
|---|---|
| With hydrogenchloride; indium In tetrahydrofuran at 20℃; for 3h; | 95% |
| With 1,3-diphenyl-disiloxane; triphenylphosphine In toluene at 23℃; for 24h; Reagent/catalyst; Solvent; Staudinger Azide Reduction; | 93% |
| With cerium(III) chloride; sodium iodide In acetonitrile for 24h; Heating; | 80% |
- 68090-03-9
4-methoxy-selenobenzamide
- 2393-23-9
4-methoxy-benzylamine
| Conditions | Yield |
|---|---|
| With samarium diiodide; water In tetrahydrofuran at 20℃; for 1h; Inert atmosphere; | 94% |
- 2393-23-9
4-methoxy-benzylamine
| Conditions | Yield |
|---|---|
| Stage #1: N-(2-(4-methoxyphenyl)-2-oxoethyl)picolinamide With hydrogenchloride In water at 20℃; for 0.0833333h; Inert atmosphere; Stage #2: With zinc In water at 20℃; for 16h; Inert atmosphere; | 91% |
4-methoxybenzylamine Chemical Properties
Molecular Structure of 4-methoxybenzylamine (CAS NO.2393-23-9):
.png)
IUPAC Name: (4-methoxyphenyl)methanamine
Empirical Formula: C8H11NO
Molecular Weight: 137.179
EINECS: 219-247-2
Melting point: -10°C
H bond acceptors: 2
H bond donors: 2
Freely Rotating Bonds: 3
Polar Surface Area: 12.47 Å2
Index of Refraction: 1.532
Molar Refractivity: 41.38 cm3
Molar Volume: 133.4 cm3
Surface Tension: 37.3 dyne/cm
Density: 1.028 g/cm3
Flash Point: 98.8 °C
Enthalpy of Vaporization: 47.33 kJ/mol
Boiling Point: 236.5 °C at 760 mmHg
Vapour Pressure: 0.0472 mmHg at 25°C
Sensitive: Air Sensitive
BRN: 508206
InChI
InChI=1/C8H11NO/c1-10-8-4-2-7(6-9)3-5-8/h2-5H,6,9H2,1H3
Smiles
O(c1ccc(cc1)CN)C
Product Categories: Anilines, Aromatic Amines and Nitro Compounds; Amine; Amines; API intermediates; C8; Nitrogen Compounds
4-methoxybenzylamine Safety Profile
Hazard Codes: 
C
Risk Statements: 34-37-22
R34:Causes burns.
R37:Irritating to respiratory system
R22:Harmful if swallowed.
Safety Statements: 26-36/37/39-45-27
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S27:Take off immediately all contaminated clothing.
RIDADR: UN 2735 8/PG 2
WGK Germany: 3
Hazard Note: Corrosive
HazardClass: 8
PackingGroup: III
HS Code: 29222900
4-methoxybenzylamine Specification
4-methoxybenzylamine , with CAS number of 2393-23-9, can be called (4-Methoxyphenyl)methanamine ; 1-(4-Methoxyphenyl)methanamine ; 1-Aminomethyl-4-methoxybenzene ; 4-Methoxybenzylamine ; 4-Methoxyphenylmethylamine ; Anisylamine ; p-Methoxybenzylamine . It is a clear colorless to slightly yellow liquid. For the synthesis of pharmaceutical intermediates.
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