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Cas Database |
| Name |
Aminopyrazine |
EINECS | 225-748-7 |
| CAS No. | 5049-61-6 | Density | 1.217 g/cm3 |
| PSA | 51.80000 | LogP | 0.64000 |
| Solubility | soluble in water | Melting Point |
118-120 °C(lit.) |
| Formula | C4H5N3 | Boiling Point | 250.905 °C at 760 mmHg |
| Molecular Weight | 95.1038 | Flash Point | 129.08 °C |
| Transport Information | N/A | Appearance | slightly yellow to beige crystalline powder |
| Safety | 26-36/37/39 | Risk Codes | 36/37/38-11 |
| Molecular Structure |
|
Hazard Symbols |
 Xi,  F
|
| Synonyms |
Pyrazinamine;Pyrazine, 1,2-dihydro-2-imino-;Pyrazine, 2-amino-;2-pyrazinamine;2-Amino Pyrazine; |
Article Data | 38 |
Aminopyrazine Synthetic route
- 32111-21-0
2-iodopyrazine
- 5049-61-6
2-Aminopyrazine
| Conditions | Yield |
|---|---|
| With copper(I) oxide; ammonia; potassium carbonate In 1,4-dioxane at 140℃; under 7757.43 Torr; for 16h; | 92% |
| With copper(I) oxide; ammonium hydroxide; potassium carbonate at 140℃; for 16h; Inert atmosphere; | 49% |
| Conditions | Yield |
|---|---|
| With palladium diacetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine In dimethyl sulfoxide regioselective reaction; | A 10% B 87% |
- 19847-12-2
2-pyrazine carbonitrile
- 5049-61-6
2-Aminopyrazine
| Conditions | Yield |
|---|---|
| With sodium hypochlorite; sodium hydroxide at 20 - 60℃; for 5h; | 82.6% |
| With sodium hypochlorite; potassium hydroxide; sodium hydroxide at 40℃; for 2h; pH=8; Temperature; | |
| With sodium hypochlorite; water; sodium hydroxide at -5 - 100℃; | 74 g |
| Conditions | Yield |
|---|---|
| With C46H71Cl3N2Pd; ammonia; sodium t-butanolate In 1,4-dioxane at 100℃; for 16h; Inert atmosphere; Schlenk technique; | A 79% B n/a |
- 14508-49-7
2-chloropyrazin
- 5049-61-6
2-Aminopyrazine
| Conditions | Yield |
|---|---|
| With dicyclohexyl(2',4',6'-triisopropyl-5-methoxy-3,4,6-trimethyl-[1,1'-biphenyl]-2-yl)phosphine; C50H70NO4PPdS; C50H70NO4PPdS; dicyclohexyl(2',4',6'-triisopropyl-4-methoxy-3,5,6-trimethyl-[1,1'-biphenyl]-2-yl)phosphine; ammonia; sodium t-butanolate In 1,4-dioxane at 50℃; for 24h; Inert atmosphere; | 75% |
| With ammonia; water at 200℃; | |
| With ammonia In dimethyl sulfoxide at 130℃; |
- 136918-14-4
phthalimide
A
- 5049-61-6
2-Aminopyrazine
B
- 457099-33-1
2-(5-Amino-pyrazin-2-ylmethyl)-isoindole-1,3-dione
| Conditions | Yield |
|---|---|
| With sodium carbonate In CH2Cl2/MeOH; dichloromethane; trifluoroacetic acid | A n/a B 73% |
| Conditions | Yield |
|---|---|
| With potassium permanganate; potassium amide In ammonia for 0.166667h; | 65% |
| Conditions | Yield |
|---|---|
| With acetamidine hydrochloride; sodium hydroxide In water; dimethyl sulfoxide at 130℃; for 24h; Schlenk technique; chemoselective reaction; | 52% |
- 94777-52-3
2-(1-hydroxyethyl)pyrazine
- 5049-61-6
2-Aminopyrazine
| Conditions | Yield |
|---|---|
| With sodium azide; methanesulfonic acid; trifluoroacetic acid In hexane at 40℃; for 12h; | 45% |
| Conditions | Yield |
|---|---|
| With [bis(acetoxy)iodo]benzene; toluene-4-sulfonic acid In 1,2-dichloro-ethane at 20℃; for 1h; Schlenk technique; chemoselective reaction; | A n/a B 28% |
Aminopyrazine Chemical Properties
IUPAC Name: Pyrazin-2-amine
Synonyms of 2-Aminopyrazine (CAS NO.5049-61-6): Aminopyrazine ; Pyrazinamine
CAS NO: 5049-61-6
Molecular Formula: C4H5N3
Molecular Weight: 95.10
Molecular Structure: 
EINECS:225-748-7
H bond acceptors: 3
H bond donors: 2
Freely Rotating Bonds: 0
Polar Surface Area: 29.02 Å2
Index of Refraction: 1.598
Molar Refractivity: 26.67 cm3
Molar Volume: 78.1 cm3
Surface Tension: 64.3 dyne/cm
Density: 1.216 g/cm3
Flash Point: 129.1 °C
Enthalpy of Vaporization: 48.82 kJ/mol
Boiling Point: 250.9 °C at 760 mmHg
Vapour Pressure: 0.0211 mmHg at 25°C
Melting Point: 118-120 °C(lit.)
Storage temp: Flammables area
Water Solubility: soluble
Appearance: slightly yellow to beige crystalline powder
Product Categories of 2-Aminopyrazine (CAS NO.5049-61-6): Fluorobenzene;pharmacetical;Pyrazine;API intermediates;Pyrazines;Chloropyrazines, etc.
Aminopyrazine Safety Profile
Safety Information about 2-Aminopyrazine (CAS NO.5049-61-6):
Hazard Codes: 
Xi
F
Risk Statements: 36/37/38-11
R11: Highly flammable.
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36/37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
WGK Germany: 3
HS Code: 29339990
Aminopyrazine Specification
General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Flammable solid.
Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam.
Handling: Use spark-proof tools and explosion proof equipment. Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage: Keep away from sources of ignition. Store in a cool, dry place. Store in a tightly closed container. Flammables-area.
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