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Bacitracin

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Name

Bacitracin

EINECS 215-786-2
CAS No. 1405-87-4 Density 1.43 g/cm3
PSA 556.17000 LogP 3.72410
Solubility soluble in water: 50 mg/mL Melting Point 221-225 °C
Formula C66H103N17O16S Boiling Point 1750.1 °C at 760 mmHg
Molecular Weight 1422.69 Flash Point 1012.2 °C
Transport Information N/A Appearance white to almost white powder
Safety 24/25 Risk Codes 20/21/22
Molecular Structure Molecular Structure of 1405-87-4 (Bacitracin) Hazard Symbols Xn
Synonyms

Bacitracin (JP14/USP);Heptonamide,5-amino-2,5,6,7-tetradeoxy-N- [1-(3,4-dihydro-8-hydroxy-1-oxo-1H-2- benzopyran-3-yl)-3-methylbutyl]-2-methyl-;Bacitracin (TN);(4R)-4-[[(2S)-2-[[2-[(1S)-1-amino-2-methyl-butyl]4,5-dihydro-1,3-thiazole-5-carbonyl]amino]-4-methyl-pentanoyl]amino]-4-[[(1S)-1-[[(3S,6R,9S,12R,15S,18R,21S)-18-(3-aminopropyl)-12-benzyl-15-butan-2-yl-3-(carbamoylmethyl)-6-(carboxymethyl)-9-(3H-imidazol-4-ylmethyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclopentacos-21-yl]carbamoyl]-2-methyl-butyl]carbamoyl]butanoic acid;Bacilliquin;Bacitracina;Bacitracin;Topitracin;Agfivin;Altracin;Bacitracin A;

 

Bacitracin Chemical Properties

Empirical Formula: C66H103N17O16S
Molecular Weight: 1422.6933 
EINECS: 215-786-2 
Index of Refraction: 1.655
Density: 1.43 g/cm3
Flash Point: 1012.2 °C
Enthalpy of Vaporization: 293.23 kJ/mol
Boiling Point: 1750.1 °C at 760 mmHg
Melting point: 221-225 °C(lit.)
Storage tempreture: 2-8 °C
Water solubility: 50 mg/mL, clear to very slightly hazy, deep yellow
Appearance: White to pale buff powder
Structure of Bacitracin (CAS NO.1405-87-4):
                        
Product Category of Bacitracin (CAS NO.1405-87-4): UVCBs-biological;Antibiotic Explorer;Air-Sensitive;Alcan Packaging;Material;Genetic Marker SelectionAntibiotics;Interferes with Cell Wall SynthesisAntibiotics;Mechanism of Action;Peptides;Spectrum of Activity;Peptide Synthesis/Antibiotics

Bacitracin History

The unique name of Bacitracin (CAS NO.1405-87-4) derives from the fact that it was isolated by John T. Goorley from a girl named Tracy. It was approved by FDA in 1948.

Bacitracin Uses

 Bacitracin (CAS NO.1405-87-4) is used in human medicine as a polypeptide antibiotic and is "approved by the U.S. Food and Drug Administration (FDA) for use in chickens and turkeys." In combination with other topical antibiotics, it is used in ointment form for topical treatment of a variety of localized skin and eye infections as bacitracin zinc salt, as well as for the prevention of wound infections. It is also commonly used as an aftercare antibiotic on tattoos, and is preferred over Neosporin because of its fewer ingredients, which lowers chances of an allergic reaction. In most cases, it has been replaced by other antibiotics. Bacitracin also can be used to distinguish Streptococcus pyogenes from Streptococcus agalactiae, with S. pyogenes being sensitive and S. agalactiae being resistant to bacitracin.

Bacitracin Toxicity Data With Reference

1.    

dnd-esc 5 µmol/L

    MUREAV    Mutation Research, 89 (1981),95.
2.    

ipr-rat LD50:190 mg/kg

    PSEBAA    Proceedings of the Society for Experimental Biology and Medicine, 64 (1947),503.
3.    

ipr-mus LD50:300 mg/kg

    NTIS**    National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) AD277-689 .
4.    

scu-mus LDLo:1300 mg/kg

    PSEBAA    Proceedings of the Society for Experimental Biology and Medicine, 64 (1947),503.
5.    

ivn-mus LD50:360 mg/kg

    PSEBAA    Proceedings of the Society for Experimental Biology and Medicine, 64 (1947),503.
6.    

orl-gpg LD50:2 g/kg

    ANTCAO    Antibiotics and Chemotherapy, 4 (1954),304.

Bacitracin Consensus Reports

Reported in EPA TSCA Inventory.

Bacitracin Safety Profile

A poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion and subcutaneous routes. Mutation data reported.
Hazard Codes: HarmfulXn
Risk Statements: 20/21/22 
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 22-24/25-45-36 
S22:Do not breathe dust. 
S24/25:Avoid contact with skin and eyes. 
S36:Wear suitable protective clothing. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)

Bacitracin Specification

 Bacitracin , its cas register number is 1405-87-4. It also can be called AI3-50147-X ; Spectrocin Plus ; and N-[[(4R)-2-[(1S,2S)-1-Amino-2-methylbutyl]-4,5-dihydro-4-thiazolyl]carbonyl]-L-leucyl-D-alpha-glutamyl-L-isoleucyl-L-lysyl-D-ornithyl-L-isoleucyl-D-phenylalanyl-L-histidyl-D-alpha-aspartyl-L-asparagine (10.4)-lactam . It is a mixture of related cyclic polypeptides. In the United States a popular brand name Neosporin contains Bacitracin as one of its antibiotic agents along with Neomycin and Polymyxin B. Bacitracin can also be bought in pure form for those with allergies. It is hazardous, so the first aid measures and others should be known. Such as: When on the skin: first, should flush skin with plenty of water immediately for at least 15 minutes while removing contaminated clothing. Secondly, get medical aid. Or in the eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Then get medical aid soon. While, it's inhaled: Remove from exposure and move to fresh air immediately. Then you have the ingesting of the product: Wash mouth out with water, and get medical aid immediately. Notes to physician: Treat supportively and symptomatically.

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