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| CAS No.: | 1405-87-4 |
|---|---|
| Name: | Bacitracin |
| Molecular Structure: | |
|
|
| Formula: | C66H103N17O16S |
| Molecular Weight: | 1422.69 |
| Synonyms: | Bacitracin (JP14/USP);Heptonamide,5-amino-2,5,6,7-tetradeoxy-N- [1-(3,4-dihydro-8-hydroxy-1-oxo-1H-2- benzopyran-3-yl)-3-methylbutyl]-2-methyl-;Bacitracin (TN);(4R)-4-[[(2S)-2-[[2-[(1S)-1-amino-2-methyl-butyl]4,5-dihydro-1,3-thiazole-5-carbonyl]amino]-4-methyl-pentanoyl]amino]-4-[[(1S)-1-[[(3S,6R,9S,12R,15S,18R,21S)-18-(3-aminopropyl)-12-benzyl-15-butan-2-yl-3-(carbamoylmethyl)-6-(carboxymethyl)-9-(3H-imidazol-4-ylmethyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclopentacos-21-yl]carbamoyl]-2-methyl-butyl]carbamoyl]butanoic acid;Bacilliquin;Bacitracina;Bacitracin;Topitracin;Agfivin;Altracin;Bacitracin A; |
| EINECS: | 215-786-2 |
| Density: | 1.43 g/cm3 |
| Melting Point: | 221-225 °C |
| Boiling Point: | 1750.1 °C at 760 mmHg |
| Flash Point: | 1012.2 °C |
| Solubility: | soluble in water: 50 mg/mL |
| Appearance: | white to almost white powder |
| Hazard Symbols: | Xn |
| Risk Codes: | 20/21/22 |
| Safety: | 24/25 |
| PSA: | 556.17000 |
| LogP: | 3.72410 |
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Chemistry
Empirical Formula: C66H103N17O16S
Molecular Weight: 1422.6933
EINECS: 215-786-2
Index of Refraction: 1.655
Density: 1.43 g/cm3
Flash Point: 1012.2 °C
Enthalpy of Vaporization: 293.23 kJ/mol
Boiling Point: 1750.1 °C at 760 mmHg
Melting point: 221-225 °C(lit.)
Storage tempreture: 2-8 °C
Water solubility: 50 mg/mL, clear to very slightly hazy, deep yellow
Appearance: White to pale buff powder
Structure of Bacitracin (CAS NO.1405-87-4):
Product Category of Bacitracin (CAS NO.1405-87-4): UVCBs-biological;Antibiotic Explorer;Air-Sensitive;Alcan Packaging;Material;Genetic Marker SelectionAntibiotics;Interferes with Cell Wall SynthesisAntibiotics;Mechanism of Action;Peptides;Spectrum of Activity;Peptide Synthesis/Antibiotics
History
The unique name of Bacitracin (CAS NO.1405-87-4) derives from the fact that it was isolated by John T. Goorley from a girl named Tracy. It was approved by FDA in 1948.
Uses
Bacitracin (CAS NO.1405-87-4) is used in human medicine as a polypeptide antibiotic and is "approved by the U.S. Food and Drug Administration (FDA) for use in chickens and turkeys." In combination with other topical antibiotics, it is used in ointment form for topical treatment of a variety of localized skin and eye infections as bacitracin zinc salt, as well as for the prevention of wound infections. It is also commonly used as an aftercare antibiotic on tattoos, and is preferred over Neosporin because of its fewer ingredients, which lowers chances of an allergic reaction. In most cases, it has been replaced by other antibiotics. Bacitracin also can be used to distinguish Streptococcus pyogenes from Streptococcus agalactiae, with S. pyogenes being sensitive and S. agalactiae being resistant to bacitracin.
Toxicity Data With Reference
| 1. | dnd-esc 5 µmol/L | MUREAV Mutation Research, 89 (1981),95. | ||
| 2. | ipr-rat LD50:190 mg/kg | PSEBAA Proceedings of the Society for Experimental Biology and Medicine, 64 (1947),503. | ||
| 3. | ipr-mus LD50:300 mg/kg | NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) AD277-689 . | ||
| 4. | scu-mus LDLo:1300 mg/kg | PSEBAA Proceedings of the Society for Experimental Biology and Medicine, 64 (1947),503. | ||
| 5. | ivn-mus LD50:360 mg/kg | PSEBAA Proceedings of the Society for Experimental Biology and Medicine, 64 (1947),503. | ||
| 6. | orl-gpg LD50:2 g/kg | ANTCAO Antibiotics and Chemotherapy, 4 (1954),304. |
Consensus Reports
Reported in EPA TSCA Inventory.
Safety Profile
A poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion and subcutaneous routes. Mutation data reported.
Hazard Codes: 
Xn
Risk Statements: 20/21/22
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 22-24/25-45-36
S22:Do not breathe dust.
S24/25:Avoid contact with skin and eyes.
S36:Wear suitable protective clothing.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
Specification
Bacitracin , its cas register number is 1405-87-4. It also can be called AI3-50147-X ; Spectrocin Plus ; and N-[[(4R)-2-[(1S,2S)-1-Amino-2-methylbutyl]-4,5-dihydro-4-thiazolyl]carbonyl]-L-leucyl-D-alpha-glutamyl-L-isoleucyl-L-lysyl-D-ornithyl-L-isoleucyl-D-phenylalanyl-L-histidyl-D-alpha-aspartyl-L-asparagine (10.4)-lactam . It is a mixture of related cyclic polypeptides. In the United States a popular brand name Neosporin contains Bacitracin as one of its antibiotic agents along with Neomycin and Polymyxin B. Bacitracin can also be bought in pure form for those with allergies. It is hazardous, so the first aid measures and others should be known. Such as: When on the skin: first, should flush skin with plenty of water immediately for at least 15 minutes while removing contaminated clothing. Secondly, get medical aid. Or in the eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Then get medical aid soon. While, it's inhaled: Remove from exposure and move to fresh air immediately. Then you have the ingesting of the product: Wash mouth out with water, and get medical aid immediately. Notes to physician: Treat supportively and symptomatically.