- Buformin [USAN:INN]
- Buformin hydrochloride
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| Name |
Buformin [USAN:INN] |
EINECS | N/A |
| CAS No. | 692-13-7 | Density | 1.22g/cm3 |
| PSA | 97.78000 | LogP | 1.47550 |
| Solubility | N/A | Melting Point |
N/A |
| Formula | C6H15 N5 | Boiling Point | 322.7°C at 760 mmHg |
| Molecular Weight | 157.219 | Flash Point | 148.9°C |
| Transport Information | N/A | Appearance | N/A |
| Safety | Poison by ingestion, subcutaneous, and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NOx. | Risk Codes | N/A |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
Biguanide,1-butyl- (6CI,8CI); 1-Butylbiguanide; Buformin; Buformine; Butformin;Butylbiguanide; Butyldiguanide; DBV; Dibetos B; Glybigid; H 224;N1-Butylbiguanide; W 37 |
Buformin [USAN:INN] Chemical Properties
Product Name: Buformin [USAN:INN]
CAS Registry Number: 692-13-7
Synonyms: 1-Butylbiguanide ; 1-Butyldiguanide ; 4-04-00-00582 (Beilstein Handbook Reference) ; BRN 0607037 ; Buformin ; Buformina ; Buformina [INN-Spanish] ; Buformine ; Buformine [INN-French] ; Buforminum ; Buforminum [INN-Latin] ; Butformin ; Butylbiguanide ; Butylbiguanidum ; Butyldiguanide ; DBV ; EINECS 211-726-4 ; Glybigid ; Glybigidum ; H 224 ; N-Butylbiguanide ; W 37 ; Biguanide, 1-butyl- ; Imidodicarbonimidic diamide, N-butyl-
IUPAC Name: 2-butyl-1-(diaminomethylidene)guanidine
Molecular Weight: 157.2168 [g/mol]
Molecular Formula: C6H15N5
EINECS: 211-726-4
XLogP3-AA: -0.6
H-Bond Donor: 3
H-Bond Acceptor: 5
Surface Tension: 49.5 dyne/cm
Density: 1.22 g/cm3
Flash Point: 148.9 °C
Enthalpy of Vaporization: 56.45 kJ/mol
Boiling Point: 322.7 °C at 760 mmHg
Vapour Pressure: 0.000275 mmHg at 25°C
Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals
Following is the molecular structure of Buformin [USAN:INN] (CAS NO.692-13-7) is:
Buformin [USAN:INN] Uses
Buformin [USAN:INN] (CAS NO.692-13-7) , clinically used for diabetes mellitus, is known to improve resistance to insulin in patients. It suppresses the expression of glyceraldehyde 3-phosphate dehydrogenase.
Buformin [USAN:INN] Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| guinea pig | LD50 | subcutaneous | 18mg/kg (18mg/kg) | Medicina Experimentalis. Vol. 8, Pg. 237, 1963. | |
| mouse | LD50 | intraperitoneal | 140mg/kg (140mg/kg) | Journal of Medicinal Chemistry. Vol. 24, Pg. 1521, 1981. | |
| mouse | LD50 | oral | 300mg/kg (300mg/kg) | Journal of Medicinal Chemistry. Vol. 24, Pg. 1521, 1981. |
Buformin [USAN:INN] Safety Profile
Poison by ingestion, subcutaneous, and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NOx.
Buformin [USAN:INN] Specification
Buformin [USAN:INN] (CAS NO.692-13-7) is an oral hypoglycemic agent that inhibits gluconeogenesis, increases glycolysis, and decreases glucose oxidation.
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