- Nitridoosmium(VI) and nitridoruthenium(VI) complexes of cysteine(2-) and related ligands
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Anionic complexes of nitridoruthenium(VI) and nitridoosmium(VI) containing covalently bound N-acetyl-L-cysteinato, 3-sulfidopropionato, and 3-sulfidopropionamidato ligands have been synthesized to model the binding of δ-(L-α-aminoadipyl)-L-cysteinyl-D-val
- Schwab, Joseph J.,Wilkinson, Elizabeth C.,Wilson, Scott R.,Shapley, Patricia A.
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- TETRAHYDROPYRAZOLO-PYRAZINYL-DIHYDROIMIDAZOLONE OR TETRAHYDROPYRAZOLO-PYRIDINYL-DIHYDROIMIDAZOLONE COMPOUNDS AND METHODS OF USING SAME
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The application relates to a compound of Formula (I) : or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, which modulates the activity of GLP-1 receptor, a pharmaceutical composition comprising a compound of Formula (I), and a method of treating or preventing a disease in which GLP-1 receptor plays a role.
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Paragraph 00562
(2022/02/05)
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- A 3 - chloroisothiazole chemical synthesis method
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The invention relates to a chemical synthesis method of 3-chloroisothiazole. The chemical synthesis method takes 4,5- dithio-1,8-octanedioic acid as a material and simply synthesizes 3-chloroisothiazole by two-step reaction. The method is as follows: adding the 4,5- dithio-1,8-octanedioic acid into thionyl chloride, evaporating out thionyl chloride after reaction is ended, adding into ammonia water, controlling a temperature to generate 4,5- dithio-1,8-octanedioyl amine; dissolving phosphorus oxychloride in an organic solvent toluene, adding 4,5- dithio-1,8-octanedioyl amine, controlling the reaction temperature at a lower temperature, increasing the temperature for reaction after reacting for 48 hours to synthesize 3-chloroisothiazole. The chemical synthesis method disclosed by the invention is low in synthesis route cost, high in yield, simple and convenient to operate, and therefore, an efficient synthesis method is provided for synthesizing the compound.
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Paragraph 0016; 0017
(2018/02/22)
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- Synthesis and antibacterial activity of 2-(4-substituted phenyl)-3(2H)-isothiazolones
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Several new and known 2-(4-substituted phenyl)-3(2H)-isothiazolone derivatives with or without chloro substituent at C-5 position were synthesized and their in vitro antibacterial activity against selected Gram-negative and Gram-positive bacteria were eva
- Khalaj, Ali,Adibpour, Neda,Shahverdi, Ahmad Reza,Daneshtalab, Mohsen
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p. 699 - 705
(2007/10/03)
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- A General Synthesis of N-Substituted Isothiazol-3(2H)-ones
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A general route to the synthesis of N-substituted isothiazol-3(2H)-ones (4a-i) is described which proceeds via trichloroacetic acid-mediated ring closure of N-substituted (Z)-3-(benzylsulfinyl)propenamides (15a-i).
- Beeley, Nigel R. A.,Harwood, Laurence M.,Hedger, Paul C.
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p. 2245 - 2252
(2007/10/02)
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- ESTER PRODRUGS
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This invention relates to ester prodrugs for alkanoic acid compounds useful as leukotriene antagonists, and pharmaceutical compositions containing such ester prodrug compounds. This invention also relates to methods of treating diseases in which leukotrienes are a factor by administration of an effective amount of the above compounds or compositions.
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- THIOPHENYL ALKANOIC ACIDS USEFUL AS LEUKOTRIENE ANTAGONISTS
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This invention relates to alkanoic acid compounds having phenyl and thio substituents which are useful as leukotriene antagonists and pharmaceutical compositions containing such compounds. This invention also relates to treating diseases in which leukotrienes are a factor by administration of an effective amount of the above compounds or compositions.
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- Leukotriene antagonists
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This invention relates to alkanoic acid compounds having phenyl and thio substituents which are useful as leukotriene antagonists and pharmaceutical compositions containing such compounds. This invention also relates to methods of treating diseases in which leukotrienes are a factor by administration of an effective amount of the above compounds or compositions.
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