1003887-62-4

Basic information

• Product Name: (S)-8-fluorochroman-4-amine
• Synonyms: (S)-8-fluorochroman-4-amine;2H-1-Benzopyran-4-aMine, 8-fluoro-3,4-dihydro-, (4S)-
• CAS NO: 1003887-62-4
• Molecular Formula: C9H10FNO
• Molecular Weight: 167.1802032
• Mol File: 1003887-62-4.mol

Chemical Properties

• Boiling Point: 228.212 °C at 760 mmHg
• Flash Point: 91.82 °C
• Appearance: /
• Density: 1.202 g/cm³
• Storage Temp.: 2-8°C
• PKA: 8.38±0.20(Predicted)
• CAS DataBase Reference: (S)-8-fluorochroman-4-amine(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-8-fluorochroman-4-amine(1003887-62-4)
• EPA Substance Registry System: (S)-8-fluorochroman-4-amine(1003887-62-4)

Safety Data

• Hazardous Substances Data: 1003887-62-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
(S)-8-Fluorochroman-4-amine is used as a key building block in the synthesis of pharmaceutical compounds for various therapeutic applications. Its unique structure allows for the creation of novel drug candidates with potential benefits in treating a range of medical conditions.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, (S)-8-Fluorochroman-4-amine serves as a valuable tool for research and development. Its properties and reactivity contribute to the understanding of compound interactions and the design of new therapeutic agents.
Used in Neurological Disorder Treatment:
(S)-8-Fluorochroman-4-amine is used as a starting material for the development of drugs targeting neurological disorders. Its potential therapeutic applications make it a promising candidate for further research and clinical trials.
Used in Drug Discovery:
As a chemical compound with unique properties, (S)-8-Fluorochroman-4-amine is utilized in drug discovery efforts to identify and develop new pharmaceutical agents. Its role in this process is crucial for advancing the treatment of various medical conditions.

Upstream product

• 791043-28-2 8-fluorochroman-4-amine 
• 6290-49-9 methyl methoxyacetate 
• 2967-72-8 3-(2-fluorophenoxy)propanoic acid 
• 111141-00-5 8-fluoro-2,3-dihydro-4-H-1-benzopyran-4-one 
• 367-12-4 2-fluorophenol 

Relevant articles and documents

2-Benzimidazolyl-9-(chroman-4-yl)-purinone derivatives as JAK3 inhibitors

A novel class of Janus tyrosine kinase 3 (JAK3) inhibitors based on a 2-benzimidazoylpurinone core structure is described. Through substitution of the benzimidazoyl moiety and optimization of the N-9 substituent of the purinone, compound 24 was identified incorporating a chroman-based functional group. Compound 24 shows excellent kinase activity, good oral bioavailability and demonstrates efficacy in an acute mechanistic mouse model through inhibition of interleukin-2 (IL-2) induced interferon-γ (INF-γ) production.

7-SUBSTITUTED PURINE DERIVATIVES FOR IMMUNOSUPPRESSION

The present invention provides novel purinone and related derivatives useful for the prevention and treatment of autoimmune diseases, inflammatory disease, mast cell mediated disease and transplant rejection. The compounds are of the general formula (III).

7-Substituted Purine Derivatives for Immunosuppression

The present invention provides novel purinone and related derivatives useful for the prevention and treatment of autoimmune diseases, inflammatory disease, mast cell mediated disease and transplant rejection. The compounds are of the general formula III:

8-SUBSTITUTED 2-(BENZIMIDAZOLYL)PURINE DERIVATIVES FOR IMMUNOSUPPRESSION

The present invention provides novel purines useful for the prevention and treatment of autoimmune diseases, inflammatory disease, mast cell mediated disease and transplant rejection. The compounds are of the general formula I:

PURINE AND IMIDAZOPYRIDINE DERIVATIVES FOR IMMUNOSUPPRESSION

The present invention provides novel purine and imidazopyridine derivatives useful for the prevention and treatment of autoimmune diseases, inflammatory disease, mast cell mediated disease and transplant rejection. The compounds are of the general formulas ( I ) and ( II ).