1004-65-5

Basic information

• Product Name: 3-Methyl-1,2,4-triazolo[4,3-a]pyridine
• Synonyms: 3-Methyl-1,2,4-triazolo[4,3-a]pyridine;3-Methyl-s-triazolo[4,3-a]pyridine;NSC 68458
• CAS NO: 1004-65-5
• Molecular Formula: C7H7N3
• Molecular Weight: 133.15
• Mol File: 1004-65-5.mol

Chemical Properties

• Melting Point: 134℃
• Appearance: /
• Density: 1.24
• Refractive Index: 1.658
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 3.97±0.50(Predicted)
• CAS DataBase Reference: 3-Methyl-1,2,4-triazolo[4,3-a]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Methyl-1,2,4-triazolo[4,3-a]pyridine(1004-65-5)
• EPA Substance Registry System: 3-Methyl-1,2,4-triazolo[4,3-a]pyridine(1004-65-5)

Safety Data

• Hazardous Substances Data: 1004-65-5(Hazardous Substances Data)

Usage

Uses

Used in Scientific Research:
3-Methyl-1,2,4-triazolo[4,3-a]pyridine is used as a research chemical for various scientific studies. Its unique structure and properties make it a valuable compound for exploring new chemical reactions and understanding its potential applications in different fields.
Used in Industrial Applications:
In the industrial sector, 3-Methyl-1,2,4-triazolo[4,3-a]pyridine is employed as a specialty chemical in the development of new materials and products. Its heterocyclic nature and aromatic characteristics contribute to its versatility in various chemical processes and formulations.

InChI:InChI=1/C7H7N3/c1-6-8-9-7-4-2-3-5-10(6)7/h2-5H,1H3

Upstream product

• 4930-98-7 pyrid-2-ylhydrazine 
• 108-24-7 acetic anhydride 
• 543-24-8 N-acetylglycine 
• 7707-99-5 acetic acid N'-pyridin-2-yl-hydrazide 
• 127-19-5 N,N-dimethyl acetamide 

Relevant articles and documents

Metal free [4+1] and [5+1] annulation reactions to prepare heterocycles using DMF and its derivatives as one-carbon source

1,2,4-Triazolo[3,4-a]pyridines and related heterocycles and substituted triazines were commonly discovered scaffolds in a variety of pharmaceutical and agrochemical agents. Herein, we report a highly efficient and practical method using DMF and its derivative for the [4+1] and [5+1] annulation reactions to prepare these heterocycles. This metal free reaction takes advantages of shelf stable DMF as solvent and carbon donor, imidazole chloride as a catalyst, the mild reaction condition tolerates a broad substrate range and substitutes. The prepared 3-unsubstituted 1,2,4-triazolo[3,4-a]pyridine and derivatives allow further introduction of a variety of functional group1 at 3-position.

Palladium-catalyzed chemoselective monoarylation of hydrazides for the synthesis of [1,2,4]Triazolo[4,3-a]pyridines

(Chemical Equation Presented) An efficient and convenient method for the synthesis of [1,2,4]triazolo[4,3-a]pyridines was exemplified by the synthesis of 20 analogues bearing a variety of substituents at the 3-position. The methodology involves a palladiu

Reactions of acylglycines with heteroarylhydrazines

Reactions of N-acylglycines with heteroarylhydrazines leading to acylamino substituted fused 1,2,4-triazoles and N-{2-[2-(heteroaryl)hydrazino]-2-oxoethyl} benzamides have been investigated.