- Metal free [4+1] and [5+1] annulation reactions to prepare heterocycles using DMF and its derivatives as one-carbon source
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1,2,4-Triazolo[3,4-a]pyridines and related heterocycles and substituted triazines were commonly discovered scaffolds in a variety of pharmaceutical and agrochemical agents. Herein, we report a highly efficient and practical method using DMF and its derivative for the [4+1] and [5+1] annulation reactions to prepare these heterocycles. This metal free reaction takes advantages of shelf stable DMF as solvent and carbon donor, imidazole chloride as a catalyst, the mild reaction condition tolerates a broad substrate range and substitutes. The prepared 3-unsubstituted 1,2,4-triazolo[3,4-a]pyridine and derivatives allow further introduction of a variety of functional group1 at 3-position.
- Liu, Lingfeng,Qiao, Chunhua,Shen, Bei,Xu, Yiwen
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- Palladium-catalyzed chemoselective monoarylation of hydrazides for the synthesis of [1,2,4]Triazolo[4,3-a]pyridines
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(Chemical Equation Presented) An efficient and convenient method for the synthesis of [1,2,4]triazolo[4,3-a]pyridines was exemplified by the synthesis of 20 analogues bearing a variety of substituents at the 3-position. The methodology involves a palladiu
- Reichelt, Andreas,Falsey, James R.,Rzasa, Robert M.,Thiel, Oliver R.,Achmatowicz, Michal M.,Larsen, Robert D.,Zhang, Dawei
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supporting information; experimental part
p. 792 - 795
(2010/04/06)
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- Reactions of acylglycines with heteroarylhydrazines
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Reactions of N-acylglycines with heteroarylhydrazines leading to acylamino substituted fused 1,2,4-triazoles and N-{2-[2-(heteroaryl)hydrazino]-2-oxoethyl} benzamides have been investigated.
- Music, Irena,Vercek, Bojan
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p. 321 - 324
(2007/10/03)
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