100561-24-8

Basic information

• Product Name: 4-(dipropylamino)-1,3,4,5-tetrahydrobenzo[cd]indole-6-carboxamide
• CAS NO: 100561-24-8
• Molecular Formula: C₁₈H₂₅N₃O
• Molecular Weight: 299.4106
• Mol File: 100561-24-8.mol

Chemical Properties

• Boiling Point: 510.1°C at 760 mmHg
• Flash Point: 262.3°C
• Density: 1.17g/cm³
• Vapor Pressure: 1.6E-10mmHg at 25°C
• Refractive Index: 1.623
• CAS DataBase Reference: 4-(dipropylamino)-1,3,4,5-tetrahydrobenzo[cd]indole-6-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(dipropylamino)-1,3,4,5-tetrahydrobenzo[cd]indole-6-carboxamide(100561-24-8)
• EPA Substance Registry System: 4-(dipropylamino)-1,3,4,5-tetrahydrobenzo[cd]indole-6-carboxamide(100561-24-8)

Safety Data

• Hazardous Substances Data: 100561-24-8(Hazardous Substances Data)

Upstream product

• 132619-33-1 (R)-4-Dipropylamino-1,3,4,5-tetrahydro-benzo[cd]indole-6-carbonitrile 
• 136791-11-2 (2aR,4S)-4-Dipropylamino-1,2,2a,3,4,5-hexahydro-benzo[cd]indole-6-carboxylic acid amide 
• 1118-02-1 trimethylsilyl isocyanate 
• 132557-17-6 (2aR,4S)-4-Dipropylamino-1,2,2a,3,4,5-hexahydro-benzo[cd]indole-6-carbonitrile 
• 39890-59-0 Phenyl-(5aS,6aS,7aR)-5a,6,6a,7a-tetrahydro-5H-7-oxa-4-aza-cyclopropa[e]acenaphthylen-4-yl-methanone 
• 132557-14-3 ((2aR,4S)-4-Amino-6-bromo-2a,3,4,5-tetrahydro-2H-benzo[cd]indol-1-yl)-phenyl-methanone 
• 132557-15-4 ((2aR,4S)-6-Bromo-4-dipropylamino-2a,3,4,5-tetrahydro-2H-benzo[cd]indol-1-yl)-phenyl-methanone 
• 132557-16-5 (+)-(2aR,4S)-1-benzoyl-4-(dipropylamino)-1,2,2α,3,4,5-hexahydrobenz-[cd]-indole-6-carbonitrile 
• 133148-99-9 N-((2aR,4S)-1-Benzoyl-1,2,2a,3,4,5-hexahydro-benzo[cd]indol-4-yl)-2,2,2-trifluoro-acetamide 
• 133445-35-9 (S)-3-((R)-1-Benzoyl-2,3-dihydro-1H-indol-3-yl)-2-(2,2,2-trifluoro-acetylamino)-propionyl chloride 
• 133148-97-7 N-((2aR,4S)-1-Benzoyl-5-oxo-1,2,2a,3,4,5-hexahydro-benzo[cd]indol-4-yl)-2,2,2-trifluoro-acetamide 
• 133148-98-8 N-((2aR,4S,5S)-1-Benzoyl-5-hydroxy-1,2,2a,3,4,5-hexahydro-benzo[cd]indol-4-yl)-2,2,2-trifluoro-acetamide 
• 133148-95-5 (S)-3-((R)-1-Benzoyl-2,3-dihydro-1H-indol-3-yl)-2-(2,2,2-trifluoro-acetylamino)-propionic acid 
• 136816-12-1 ((2aR,4S)-4-Amino-6-iodo-2a,3,4,5-tetrahydro-2H-benzo[cd]indol-1-yl)-phenyl-methanone 

Relevant articles and documents

The synthesis of carbon-14 labeled (R)-4-(dipropylamino)-1,3,4,5- tetrahydrobenz[cd]indole-6-carboxamide hippurate. A partial ergoline with 5-HT1A agonist activity and an 125I-labeled analog

Partial ergoline agonists such as (R)-4-(dipropylamino)-1,3,4,5- tetrahydrobenz[cd]-indole-6-carboxamide (LY228729, 1a) mimic a locked conformational analog of serotonin and in fact possess potent in vitro activity as agonists of the 5-HT1A receptor. In the course of pre-clinical investigation of la for potential use as an anxiolytic agent, 1b was prepared in a five step synthesis from K14CN. In addition, an 125I-analog of 1a was prepared for aid in the development of a radioimmunoassay (RIA). Copyright

Synthetic studies toward the partial ergot alkaloid LY228729, a potent 5HT(1A) receptor agonist

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