1006376-62-0

Basic information

• Product Name: (1R,2R)-2-(3,4-difluorophenyl)cyclopropane carboxaMide
• Synonyms: (1R,2R)-2-(3,4-difluorophenyl)cyclopropane-1-carboxamide;(1R,2R)-2-(3,4-difluorophenyl)cyclopropane carboxaMide;Cyclopropanecarboxamide, 2-(3,4-difluorophenyl)-, (1R,2R)-
• CAS NO: 1006376-62-0
• Molecular Formula: C₁₀H₉F₂NO
• Molecular Weight: 197
• EINECS: -0
• Mol File: 1006376-62-0.mol

Chemical Properties

• Boiling Point: 347.9±42.0 °C(Predicted)
• Appearance: /
• Density: 1.366±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 16.43±0.40(Predicted)
• CAS DataBase Reference: (1R,2R)-2-(3,4-difluorophenyl)cyclopropane carboxaMide(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2R)-2-(3,4-difluorophenyl)cyclopropane carboxaMide(1006376-62-0)
• EPA Substance Registry System: (1R,2R)-2-(3,4-difluorophenyl)cyclopropane carboxaMide(1006376-62-0)

Safety Data

• Hazardous Substances Data: 1006376-62-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(1R,2R)-2-(3,4-difluorophenyl)cyclopropane carboxaMide is used as a key intermediate in the synthetic preparation of ticagrelor derivatives. These derivatives serve as antiplatelet agents, which are crucial in the prevention and treatment of conditions related to blood clotting, such as heart attacks and strokes.
Application Reason:
The compound's unique structure allows it to effectively inhibit ADP-induced platelet aggregation, a process that can lead to the formation of blood clots. By incorporating (1R,2R)-2-(3,4-difluorophenyl)cyclopropane carboxaMide into the synthesis of ticagrelor derivatives, researchers can develop more potent and selective antiplatelet agents, potentially improving patient outcomes and reducing the risk of clot-related complications.

Upstream product

• 376608-70-7 trans-(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarbonyl chloride 
• 1006376-61-9 (1R,2R)-2-(3,4-difluorophenyl)-1-cyclopropanecarboxylic acid ethyl ester 
• 220352-36-3 trans-(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid 
• 1006376-60-8 (1S)-2-chloro-1-(3,4-difluorophenyl)-1-ethanol 
• 1006376-63-1 (S)-2-(3,4-difluorophenyl)ethylene oxide 
• 1450916-28-5 (1R,2R)-2-(3,4-difluorophenyl)cyclopropane carbonitrile 
• 1459720-02-5 (1R,2S)-2-(3,4-difluorophenyl)cyclopropanoic acid methyl ester 
• 168267-41-2 (3,4-difluorophenyl)boronic acid 
• 85118-01-0 alpha-bromo-3,4-difluorotoluene 
• 77287-34-4 formamide 
• 451455-95-1 diethyl (3,4-difluoro-benzyl)phosphonate 
• 1248202-12-1 4-keto-4-(3,4-difluorophenyl)butyric acid methyl ester 
• 1267369-02-7 isopropyl 4-(3,4-difluorophenyl)-4-oxobutanoate 

Downstream Products

• 1006614-49-8 (1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine 
• 274693-27-5 ticagrelor 
• 220347-05-7 AR-C₁₂₄₉₁₀XX 
• 274693-49-1 (3aR,4S,6R,6aS)-6-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-ol 
• 1381841-44-6 2-((1S,2S,3S,4R)-4-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino-5-propylthio-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyl)oxy) thyl carbonate 
• 1381841-46-8 2-((1S,2S,3S,4R)-4-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino-5-propylthio-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyl)oxy)ethyl isobutyl carbonate 
• 1381841-52-6 (1S,2S,3S,4R)-4-(7-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino-5-propylthio-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyl butyrate 
• 1381841-55-9 (1S,2S,3S,4R)-4-(7-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino-5-propylthio-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyl ethyl carbonate 
• 1381841-56-0 (1S,2S,3S,4R)-4-(7-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino-5-propylthio-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyl isobutyl carbonate 
• 274693-26-4 [3aR-[3aα,4α,6α,(1R,2S),6aα]]-2-[6-[[[7-(2-(3,4-difluorophenyl)cyclopropyl)]amino-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]tetrahydro-2,2-dimethyl-4H-cyclopenteno-1,3-dioxolan-4-yl]oxy]ethanol 
• 1381841-39-9 2-((1S,2S,3S,4R)-4-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino-5-propylthio-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyl)oxy)ethyl butyrate 
• 376608-71-8 trans-(1R,2S)-2-(3,4-difluorophenyl)cyclopropylamine (2R)-2-hydroxy-2-phenylacetic acid salt 
• 2096989-55-6 [1S-[1a,2a,3β(1S*,2R*),5B]]-3-[7-[2-(3,4-difluorophenyl)cyclopropylamino]-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidine-3-yl]-5-(2-hydroxyethoxy)cyclopentane-1,2-diol 
• 1402222-66-5 trans-(1R,2S)-2-(3,4-difluorophenyl)cyclopropylamine hydrochloride 

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