- Target protein degradation inducing compound, preparation method thereof and pharmaceutical composition for preventing or treating targeted protein related diseases containing the same as an active ingredient
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The present invention relates to a degraducer for inducing the decomposition of target protein, a producing method thereof, and a pharmaceutical composition for preventing or treating target protein-related diseases by containing the degraducer as an active ingredient. A novel compound represented by chemical formula 1, ULB-L-PTM, by the present invention, as a degraducer compound inducing the decomposition of target protein using cereblon E3 ubiquitin ligase, is able to significantly achieve a target protein degradation-inducing activity with an excellent binding activity of a cereblon E3 ubiquitin ligase binder thereby, being able to achieve an excellent protein degradation activity by targeting protein or polypeptide related to various diseases. The bromodomain-containing pharmaceutical composition for preventing or treating protein-related diseases or conditions contains the novel compound represented by chemical formula 1 as an active ingredient and has a useful effect of providing a health functional food composition for prevention or improvement.(AA) Example 22 (nM, 24h)COPYRIGHT KIPO 2020
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Paragraph 1131; 1133-1135
(2020/05/01)
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- Containing oligomeric ethylene oxide unit and its preparation method for compound silicon nitrile class, use in lithium batteries
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The invention provides silicone-nitrile compounds containing low polyoxyethylene units, which as shown in formula I, as well as a preparation method for the compounds and application of the compounds in a lithium battery. A nitrile group has characteristic capable of improving a dielectric constant of the substances; the nitrile group is introduced into organic silicon by the compounds, so that oxidation resistance and salt dissolving capacity of an organic silicon-based material are improved; meanwhile, high safety of an organic silicon solvent containing the low polyoxyethylene (EO) unit and ability of assisting propylene carbonate (PC) to form a film are retained. The silicone-nitrile compounds containing low polyoxyethylene units disclosed by the invention can be used as an ethylene carbonate-based or propylene carbonate-based cosolvent for being applied to the lithium battery. Compared with the conventional lithium battery electrolyte material, the silicone-nitrile compounds disclosed by the invention have a higher dielectric constant, a simpler molecular structure, and a simpler and more economical synthesis process.
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Paragraph 0032; 0034-0036
(2017/02/09)
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- Aminopropylation of alcohols in the presence of amide or ether solvents
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This invention relates to an improved hydrogenation process for the preparation of etheramines. In the process, cyanoethylated alcohols, i.e., the reaction product of an alcohol with (meth)acrylonitrile, are contacted with hydrogen in the presence of a sponge cobalt catalyst. The improvement in the process resides in effecting the hydrogenation process utilizing a cyanoethylated alcohol feedstock contaminated with byproduct acrylonitrile and utilizing a solvent that solubilizes byproduct (meth)acrylonitrile present in the feedstock. Specific classes of solvents employed are ethers and amides.
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Page/Page column 3; 4
(2008/06/13)
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- SYNTHESIS AND TRANSFORMATION OF OXYGEN-CONTAINING MONO- AND DINITRILES. I. REACTION OF β-CHLOROPROPIONITRILES WITH DIOLS
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In the reaction of β-chloropropionitrile with diols 7-11-membered oxygen-containing mono- and dinitriles were synthesized in ratios of 3:2 respectively, irrespective of the ratio of the initial components.Alkaline hydrolysis of oxygen-containing mononitriles with a weak solution of hydrogen peroxide leads to the formation of the corresponding amides, while alkaline hydrolysis of the oxygen-containing dinitriles leads to two products (amidonitriles and diamides).
- Movsumzade, E. M.,Rasulbekova, T. I.,Kulieva, D. A.,Aliev, G. R.,Movsumzade, S. M.
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p. 2132 - 2135
(2007/10/02)
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