1014613-05-8Relevant articles and documents
Pyrrolo[2,3-b]pyridine derivatives as potent Bruton's tyrosine kinase inhibitors
Zhao, Xinge,Huang, Wei,Wang, Yazhou,Xin, Minhang,Jin, Qiu,Cai, Jianfeng,Tang, Feng,Zhao, Yong,Xiang, Hua
, p. 4344 - 4353 (2015)
A series of pyrrolo[2,3-b]pyridine-based derivatives were designed as potent Bruton's tyrosine kinase (BTK) inhibitors by using a scaffold-hopping strategy. Structure-activity relationship studies identified five compounds (3n, 3p, 3q, 3r, and 3s) with IC
Indazole derivatives for use in the treatment of influenza virus infection
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, (2016/06/01)
The present invention is directed to compounds for use in the treatment or prevention of influenza virus infection.
Azaquinazoline Inhibitors Of Atypical Protein Kinase C
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, (2015/12/24)
The present application provides a compound of formula (I) and/or a salt thereof, wherein R1, G, and X are as defined herein. A compound of formula (I) and/or its salts have aPKC inhibitory activity, and may be used to treat proliferative disor
NOVEL COMPOUNDS
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, (2013/02/27)
The present invention relates to novel NADPH oxidase II inhibitors and their use in the treatment of diseases mediated by the NADPH oxidase enzymes.
NOVEL COMPOUNDS
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, (2011/06/25)
The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of PI3-kinase activity.
ETHYNYLINDOLE COMPOUNDS
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Page/Page column 21, (2010/07/04)
As a compound having a potent oral activity and a long-lasting cysLT1/cysLT2 receptor antagonistic activity, the compound of the formula (I): which exhibits potent antagonistic activity against the cysLT1/cysLT2 /sub
BENZPYRAZOL DERIVATIVES AS INHIBITORS OF PI3 KINASES
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, (2009/12/28)
The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I) and salts thereof. The compounds of the invention are inhibitors of PI3-kinase activity.
4-Phenyl-7-azaindoles as potent and selective IKK2 inhibitors
Liddle, John,Bamborough, Paul,Barker, Michael D.,Campos, Sebastien,Cousins, Rick P.C.,Cutler, Geoffrey J.,Hobbs, Heather,Holmes, Duncan S.,Ioannou, Chris,Mellor, Geoff W.,Morse, Mary A.,Payne, Jeremy J.,Pritchard, John M.,Smith, Kathryn J.,Tape, Daniel T.,Whitworth, Caroline,Williamson, Richard A.
scheme or table, p. 2504 - 2508 (2009/12/25)
The synthesis and SAR of a novel series of IKK2 inhibitors are described. Modification around the hinge binding region of the 7-azaindole led to a series of potent and selective inhibitors with good cellular activity.
PYRROLO [2, 3-B] PYRIDIN DERIVATIVES AS IKK2 INHIBITORS
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Page/Page column 62, (2009/10/22)
The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds according to formula (I):and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular IKK2 activity.
NOVEL COMPOUNDS
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, (2009/01/20)
The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds according to formula (I) and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular IKK2 activity.