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4-Bromo-2-methyl-1-phenylsulfonyl-7-azaindole is a chemical compound characterized by the molecular formula C16H13BrN2O2S and a molecular weight of 372.25 g/mol. It is an azaindole derivative featuring a bromo substituent at the 4-position and methyl and phenylsulfonyl groups at the 2-position. This unique structure and the presence of functional groups make it a promising candidate for applications in organic synthesis and medicinal chemistry.

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  • 1014613-05-8 Structure
  • Basic information

    1. Product Name: 4-Bromo-2-methyl-1-phenylsulfonyl-7-azaindole
    2. Synonyms: 1-(benzenesulfonyl)-4-bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine;1-(phenylsulfonyl)-4-bromo-2-methyl-7-azaindole;1-(Benzenesulfonyl)-4-bromo-2-methyl-pyrrolo[2,3-b]pyridine;4-Bromo-2-methyl-1-phenylsulfonyl-7-azaindole;4-BroMo-2-Methyl-1-(benzenesulfonyl)-1H-pyrrolo[2,3-b]pyridine;4-BroMo-2-Methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine;1H-Pyrrolo[2,3-b]pyridine, 4-broMo-2-Methyl-1-(phenylsulfonyl)-;1-(Phenylsulphonyl)-4-broMo-2-Methyl-7-azaindole
    3. CAS NO:1014613-05-8
    4. Molecular Formula: C14H11BrN2O2S
    5. Molecular Weight: 351.21834
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1014613-05-8.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: N/A
    9. CAS DataBase Reference: 4-Bromo-2-methyl-1-phenylsulfonyl-7-azaindole(CAS DataBase Reference)
    10. NIST Chemistry Reference: 4-Bromo-2-methyl-1-phenylsulfonyl-7-azaindole(1014613-05-8)
    11. EPA Substance Registry System: 4-Bromo-2-methyl-1-phenylsulfonyl-7-azaindole(1014613-05-8)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1014613-05-8(Hazardous Substances Data)

1014613-05-8 Usage

Uses

Used in Organic Synthesis:
4-Bromo-2-methyl-1-phenylsulfonyl-7-azaindole is used as a building block in organic synthesis for the creation of various complex organic molecules. Its unique structure and functional groups facilitate the formation of new chemical entities with potential applications in different fields.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 4-Bromo-2-methyl-1-phenylsulfonyl-7-azaindole is used as a key intermediate in the synthesis of pharmaceuticals. Its structural features and functional groups can be exploited to design and develop new drugs with improved therapeutic properties.
Used in Agrochemicals:
4-Bromo-2-methyl-1-phenylsulfonyl-7-azaindole may also find applications in the agrochemical industry as a building block for the synthesis of agrochemicals. Its unique structure and functional groups can contribute to the development of novel agrochemicals with enhanced efficacy and selectivity.
Used in Disease Treatment:
Due to its potential biological activity, 4-Bromo-2-methyl-1-phenylsulfonyl-7-azaindole may be explored for its therapeutic potential in the treatment of various diseases or conditions. Further research and exploration of its properties may reveal its potential as a lead compound in drug discovery and development.

Check Digit Verification of cas no

The CAS Registry Mumber 1014613-05-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,1,4,6,1 and 3 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1014613-05:
(9*1)+(8*0)+(7*1)+(6*4)+(5*6)+(4*1)+(3*3)+(2*0)+(1*5)=88
88 % 10 = 8
So 1014613-05-8 is a valid CAS Registry Number.

1014613-05-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(benzenesulfonyl)-4-bromo-2-methylpyrrolo[2,3-b]pyridine

1.2 Other means of identification

Product number -
Other names 4-BROMO-2-METHYL-1-(PHENYLSULFONYL)-1H-PYRROLO[2,3-B]PYRIDINE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1014613-05-8 SDS

1014613-05-8Relevant articles and documents

Pyrrolo[2,3-b]pyridine derivatives as potent Bruton's tyrosine kinase inhibitors

Zhao, Xinge,Huang, Wei,Wang, Yazhou,Xin, Minhang,Jin, Qiu,Cai, Jianfeng,Tang, Feng,Zhao, Yong,Xiang, Hua

, p. 4344 - 4353 (2015)

A series of pyrrolo[2,3-b]pyridine-based derivatives were designed as potent Bruton's tyrosine kinase (BTK) inhibitors by using a scaffold-hopping strategy. Structure-activity relationship studies identified five compounds (3n, 3p, 3q, 3r, and 3s) with IC

Indazole derivatives for use in the treatment of influenza virus infection

-

, (2016/06/01)

The present invention is directed to compounds for use in the treatment or prevention of influenza virus infection.

Azaquinazoline Inhibitors Of Atypical Protein Kinase C

-

, (2015/12/24)

The present application provides a compound of formula (I) and/or a salt thereof, wherein R1, G, and X are as defined herein. A compound of formula (I) and/or its salts have aPKC inhibitory activity, and may be used to treat proliferative disor

NOVEL COMPOUNDS

-

, (2013/02/27)

The present invention relates to novel NADPH oxidase II inhibitors and their use in the treatment of diseases mediated by the NADPH oxidase enzymes.

NOVEL COMPOUNDS

-

, (2011/06/25)

The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of PI3-kinase activity.

ETHYNYLINDOLE COMPOUNDS

-

Page/Page column 21, (2010/07/04)

As a compound having a potent oral activity and a long-lasting cysLT1/cysLT2 receptor antagonistic activity, the compound of the formula (I): which exhibits potent antagonistic activity against the cysLT1/cysLT2 /sub

BENZPYRAZOL DERIVATIVES AS INHIBITORS OF PI3 KINASES

-

, (2009/12/28)

The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I) and salts thereof. The compounds of the invention are inhibitors of PI3-kinase activity.

4-Phenyl-7-azaindoles as potent and selective IKK2 inhibitors

Liddle, John,Bamborough, Paul,Barker, Michael D.,Campos, Sebastien,Cousins, Rick P.C.,Cutler, Geoffrey J.,Hobbs, Heather,Holmes, Duncan S.,Ioannou, Chris,Mellor, Geoff W.,Morse, Mary A.,Payne, Jeremy J.,Pritchard, John M.,Smith, Kathryn J.,Tape, Daniel T.,Whitworth, Caroline,Williamson, Richard A.

scheme or table, p. 2504 - 2508 (2009/12/25)

The synthesis and SAR of a novel series of IKK2 inhibitors are described. Modification around the hinge binding region of the 7-azaindole led to a series of potent and selective inhibitors with good cellular activity.

PYRROLO [2, 3-B] PYRIDIN DERIVATIVES AS IKK2 INHIBITORS

-

Page/Page column 62, (2009/10/22)

The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds according to formula (I):and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular IKK2 activity.

NOVEL COMPOUNDS

-

, (2009/01/20)

The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds according to formula (I) and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular IKK2 activity.

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